Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2015 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2015 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Biological and therapeutic activities, and anticancer properties of curcumin (Review)

  • Authors:
    • Donatella Perrone
    • Fatima Ardito
    • Giovanni Giannatempo
    • Mario Dioguardi
    • Giuseppe Troiano
    • Lucio Lo Russo
    • Alfredo De Lillo
    • Luigi Laino
    • Lorenzo Lo Muzio
  • View Affiliations / Copyright

    Affiliations: Department of Clinical and Experimental Medicine, Foggia University, Foggia 71122, Italy
  • Pages: 1615-1623
    |
    Published online on: September 17, 2015
       https://doi.org/10.3892/etm.2015.2749
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant. Curcumin has been used extensively in Ayurvedic medicine, as it is nontoxic and exhibits a variety of therapeutic properties, including antioxidant, analgesic, anti‑inflammatory and antiseptic activities. Recently, certain studies have indicated that curcumin may exert anticancer effects in a variety of biological pathways involved in mutagenesis, apoptosis, tumorigenesis, cell cycle regulation and metastasis. The present study reviewed previous studies in the literature, which support the therapeutic activity of curcumin in cancer. In addition, the present study elucidated a number of the challenges concerning the use of curcumin as an adjuvant chemotherapeutic agent. All the studies reviewed herein suggest that curcumin is able to exert anti‑inflammatory, antiplatelet, antioxidative, hepatoprotective and antitumor activities, particularly against cancers of the liver, skin, pancreas, prostate, ovary, lung and head neck, as well as having a positive effect in the treatment of arthritis.
View Figures

Figure 1

View References

1 

Takahashi M, Ishiko T, Kamohara H, Hidaka H, Ikeda O, Ogawa M and Baba H: Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) blocks the chemotaxis of neutrophils by inhibiting signal transduction through IL-8 receptors. Mediators Inflamm. 2007:107672007.PubMed/NCBI

2 

Jurenka JS: Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Altern Med Rev. 14:141–153. 2009.PubMed/NCBI

3 

Wilken R, Veena MS, Wang MB and Srivatsan ES: Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer. 10:122011. View Article : Google Scholar : PubMed/NCBI

4 

Miłobȩdzka J, Kostanecki S and Lampe V: Notes on Curcumins. Ber Deut Chem Ges. 43:2163–2170. 1910.(In German).

5 

Sharma RA, Gescher AJ and Steward WP: Curcumin: The story so far. Eur J Cancer. 41:1955–1968. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, Limtrakul P, Badmaev V and Aggarwal BB: Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis. 28:1765–1773. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Gupta SC, Kismali G and Aggarwal BB: Curcumin, a component of turmeric: From farm to pharmacy. Biofactors. 39:2–13. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Kumar A, Ahuja A, Ali J and Baboota S: Conundrum and therapeutic potential of curcumin in drug delivery. Crit Rev Ther Drug Carrier Syst. 27:279–312. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Ammon HP and Wahl MA: Pharmacology of Curcuma longa. Planta Med. 57:1–7. 1991. View Article : Google Scholar : PubMed/NCBI

10 

Lev-Ari S, Strier L, Kazanov D, Elkayam O, Lichtenberg D, Caspi D and Arber N: Curcumin synergistically potentiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells. Rheumatology (Oxford). 45:171–177. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Neerati P, Devde R and Gangi AK: Evaluation of the effect of curcumin capsules on glyburide therapy in patients with type-2 diabetes mellitus. Phytother Res. 28:1796–1800. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Kim YS, Young MR, Bobe G, Colburn NH and Milner JA: Bioactive food components, inflammatory targets and cancer prevention. Cancer Prev Res (Phila). 2:200–208. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Bhullar KS, Jha A, Youssef D and Rupasinghe HP: Curcumin and its carbocyclic analogs: Structure-activity in relation to antioxidant and selected biological properties. Molecules. 18:5389–5404. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Somchit M, Changtam C, Kimseng R, Utaipan T, Lertcanawanichakul M, Suksamrarn A and Chunglok W: Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 15:1807–1810. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Li YB, Gao JL, Zhong ZF, Hoi PM, Lee SM and Wang YT: Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 65:700–709. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Food and Drug Administration (FDA): Food for Human Consumption; Part 182 - Substances generally recognized as safe. http://accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.10Accessed. 2011

17 

Aggarwal BB, Deb L and Prasad S: Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. Molecules. 20:185–205. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Masuda T, Hidaka K, Shinohara A, Maekawa T, Takeda Y and Yamaguchi H: Chemical studies on antioxidant mechanism of curcuminoid: Analysis of radical reaction products from curcumin. J Agric Food Chem. 47:71–77. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY and Lin JK: Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal. 15:1867–1876. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Prasad K, Mantha SV, Kalra J and Lee P: Prevention of hypercholesterolemic atherosclerosis by garlic, an antixoidant. J Cardiovasc Pharmacol Ther. 2:309–320. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Surh YJ and Chun KS: Cancer chemopreventive effects of curcumin. Adv Exp Med Biol. 595:149–172. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK and Lee SS: Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: Down-regulation of COX-2 and iNOS through suppression of NF-kappaB activation. Mutat Res. 480(481): 243–268. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Hong J, Bose M, Ju J, Ryu JH, Chen X, Sang S, Lee MJ and Yang CS: Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: Effects on cytosolic phospholipase A (2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis. 25:1671–1679. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Zhang F, Altorki NK, Mestre JR, Subbaramaiah K and Dannenberg AJ: Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells. Carcinogenesis. 20:445–451. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Li Y, Zhang S, Geng JX and Hu XY: Curcumin inhibits human non-small cell lung cancer A549 cell proliferation through regulation of Bcl-2/Bax and cytochrome C. Asian Pac J Cancer Prev. 14:4599–4602. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Koeberle A, Northoff H and Werz O: Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1. Mol Cancer Ther. 8:2348–2355. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Divya CS and Pillai MR: Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NF-kB and AP-1 translocation and modulation of apoptosis. Mol Carcinog. 45:320–332. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Hess J, Angel P and Schorpp-Kistner M: AP-1 subunits: Quarrel and harmony among siblings. J Cell Sci. 117:5965–5973. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Panicker SR and Kartha CC: Curcumin attenuates glucose-induced monocyte chemoattractant protein-1 synthesis in aortic endothelial cells by modulating the nuclear factor-kappaB pathway. Pharmacology. 85:18–26. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Aggarwal BB, Sundaram C, Malani N and Ichikawa H: Curcumin: The Indian solid gold. Adv Exp Med Biol. 595:1–75. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Huang YF, Zhu XX, Ding ZS and Lv GY: Study on anti-angiogenesis effect of three curcumin pigments and expression of their relevant factors. Zhongguo Zhong Yao Za Zhi. 40:324–329. 2015.(In Chinese). PubMed/NCBI

32 

Arbiser JL, Klauber N, Rohan R, van Leeuwen R, Huang MT, Fisher C, Flynn E and Byers HR: Curcumin is an in vivo inhibitor of angiogenesis. Mol Med. 4:376–383. 1998.PubMed/NCBI

33 

Gururaj AE, Belakavadi M, Venkatesh DA, Marmé D and Salimath BP: Molecular mechanisms of anti-angiogenic effect of curcumin. Biochem Biophys Res Commun. 297:934–942. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Biswas S and Rahman I: Modulation of steroid activity in chronic inflammation: A novel anti-inflammatory role for curcumin. Mol Nutr Food Res. 52:987–994. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Yadav R, Jee B and Awasthi SK: Curcumin suppresses the production of pro-inflammatory cytokine interleukin-18 in lipopolysaccharide stimulated murine macrophage-like cells. Indian J Clin Biochem. 30:109–112. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Funk JL, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, Sólyom AM and Timmermann BN: Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat Prod. 69:351–355. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Funk JL, Frye JB, Oyarzo JN, Kuscuoglu N, Wilson J, McCaffrey G, Stafford G, Chen G, Lantz RC, Jolad SD, et al: Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 54:3452–3464. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Nonose N, Pereira JA, Machado PR, Rodrigues MR, Sato DT and Martinez CA: Oral administration of curcumin (Curcuma longa) can attenuate the neutrophil inflammatory response in zymosan-induced arthritis in rats. Acta Cir Bras. 29:727–734. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A and Sahebkar A: Curcuminoid treatment for knee osteoarthritis: A randomized double-blind placebo-controlled trial. Phytother Res. 28:1625–1631. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Srivastava R, Dikshit M, Srimal RC and Dhawan BN: Anti-thrombotic effect of curcumin. Trhomb Res. 40:413–417. 1985. View Article : Google Scholar

41 

Shah BH, Nawaz Z, Pertani SA, Roomi A, Mahmood H, Saeed SA and Gilani AH: Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol. 58:1167–1172. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Liu AC, Zhao LX and Lou HX: Curcumin alters the pharmacokinetics of warfarin and clopidogrel in Wistar rats but has no effect on anticoagulation or antiplatelet aggregation. Planta Med. 79:971–977. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Lala PK and Chakraborty C: Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol. 2:149–156. 2001. View Article : Google Scholar : PubMed/NCBI

44 

de Rojas-Walker T, Tamir S, Ji H, Wishnok JS and Tannenbaum SR: Nitric oxide induces oxidative damage in addition to deamination in macrophage DNA. Chem Res Toxicol. 8:473–477. 1995. View Article : Google Scholar : PubMed/NCBI

45 

Graziewicz M, Wink DA and Laval F: Nitric oxide inhibits DNA ligase activity: Potential mechanisms for NO-mediated DNA damage. Carcinogenesis. 17:2501–2505. 1996. View Article : Google Scholar : PubMed/NCBI

46 

Mourtas S, Lazar AN, Markoutsa E, Duyyckaerts C and Antimisiaris SG: Multifunctional nanoliposomes with curcumin-lipid derivative and brain targeting functionality with potential applications for Alzheimer disease. Eur J Med Chem. 80:175–183. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Fang L, Gou S, Liu X, Cao F and Cheng L: Design, synthesis and anti-Alzheimer properties of dimethylaminomethyl-substituted curcumin derivatives. Bioorg Med Chem Lett. 24:40–43. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Lazar AN, Mourtas S, Youssef I, Parizot C, Dauphin A, Delatour B, Antimisiaris SG and Duyckaerts C: Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease. Nanomedicine. 9:712–721. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Belkacemi A, Doggui S, Dao L and Ramassamy C: Challenges associated with curcumin therapy in Alzheimer disease. Expert Rev Mol Med. 13:e342011. View Article : Google Scholar : PubMed/NCBI

50 

Motterlini R, Foresti R, Bassi R and Green CJ: Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med. 28:1303–1312. 2000. View Article : Google Scholar : PubMed/NCBI

51 

Scapagnini G, Colombrita C, Amadio M, D'Agata V, Arcelli E, Sapienza M, Quattrone A and Calabrese V: Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxid Redox Signal. 8:395–403. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Miao M, Guo L, Tian S and Wang T: Effects of curcumin on antioxidation in diabetic rats. Pak J Pharm Sci. 28(Suppl 1): 371–373. 2015.PubMed/NCBI

53 

Liu Y, Wu YM, Yu Y, Cao CS, Zhang JH, Li K and Zhang PY: Curcumin and resveratrol in combination modulate drug-metabolizing enzymes as well as antioxidant indices during lung carcinogenesis in mice. Hum Exp Toxicol. 34:620–627. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Kamalakkannan N, Rukkumani R, Varma PS, Viswanathan P, Rajasekharan KN and Menon VP: Comparative effects of curcumin and an analogue of curcumin in carbon tetrachloride-induced hepatotoxicity in rats. Basic Clin Pharmacol Toxicol. 97:15–21. 2005. View Article : Google Scholar : PubMed/NCBI

55 

Reyes-Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno MG and Muriel P: Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta. 1770:989–996. 2007. View Article : Google Scholar : PubMed/NCBI

56 

Sugiyama T, Nagata J, Yamagishi A, Endoh K, Saito M, Yamada K, Yamada S and Umegaki K: Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats. Life Sci. 78:2188–2193. 2006. View Article : Google Scholar : PubMed/NCBI

57 

Maheshwari RK, Singh AK, Gaddipati J and Srimal RC: Multiple biological activities of curcumin: A short review. Life Sci. 78:2081–2087. 2006. View Article : Google Scholar : PubMed/NCBI

58 

Yance DR Jr and Sagar SM: Targeting angiogenesis with integrative cancer therapies. Integr Cancer Ther. 5:9–29. 2006. View Article : Google Scholar : PubMed/NCBI

59 

Karunagaran D, Rashmi R and Kumar TR: Induction of apoptosis by curcumin and its implications for cancer therapy. Curr Cancer Drug Targets. 5:117–129. 2005. View Article : Google Scholar : PubMed/NCBI

60 

Helson L: Curcumin (diferuloylmethane) delivery methods: A review. Biofactors. 39:21–26. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Salvioli S, Sikora E, Cooper EL and Franceschi C: Curcumin in cell death processes: A challenge for CAM of age-related pathologies. Evid Based Complement Alternat Med. 4:181–190. 2007. View Article : Google Scholar : PubMed/NCBI

62 

Yang JY, Zhong X, Yum HW, Lee HJ, Kundu JK, Na HK and Surh YJ: Curcumin inhibits STAT3 signaling in the colon of dextran sulfate sodium-treated mice. J Cancer Prev. 18:186–191. 2013. View Article : Google Scholar : PubMed/NCBI

63 

Vallianou NG, Evangelopoulos A, Schizas N and Kazazis C: Potential anticancer properties and mechanisms of action of curcumin. Anticancer Res. 35:645–651. 2015.PubMed/NCBI

64 

Chuang SE, Cheng AL, Lin JK and Kuo ML: Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. Food Chem Toxicol. 38:991–995. 2000. View Article : Google Scholar : PubMed/NCBI

65 

Busquets S, Carbó N, Almendro V, Quiles MT, López-Soriano FJ and Argilés JM: Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model. Cancer Lett. 167:33–38. 2001. View Article : Google Scholar : PubMed/NCBI

66 

Huang MT, Wang ZY, Georgiadis CA, Laskin JD and Conney AH: Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene. Carcinogenesis. 13:2183–2186. 1992. View Article : Google Scholar : PubMed/NCBI

67 

Huang MT, Ma W, Lu YP, Chang RL, Fisher C, Manchand PS, Newmark HL and Conney AH: Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion. Carcinogenesis. 16:2493–2497. 1995. View Article : Google Scholar : PubMed/NCBI

68 

Huang MT, Ma W, Yen P, Xie JG, Han J, Frenkel K, Grunberger D and Conney AH: Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis. Carcinogenesis. 18:83–88. 1997. View Article : Google Scholar : PubMed/NCBI

69 

Huang MT, Smart RC, Wong CQ and Conney AH: Inhibitory effect of curcumin, chlorogenic acid, caffeic acid and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 48:5941–5946. 1988.PubMed/NCBI

70 

Jiang AJ, Jiang G, Li LT and Zheng JN: Curcumin induces apoptosis through mitochondrial pathway and caspases activation in human melanoma cells. Mol Biol Rep. 42:267–275. 2015. View Article : Google Scholar : PubMed/NCBI

71 

Li L, Braiteh FS and Kurzrock R: Liposome-encapsulated curcumin: In vitro and in vivo effects on proliferation, apoptosis, signaling and angiogenesis. Cancer. 104:1322–1331. 2005. View Article : Google Scholar : PubMed/NCBI

72 

Bao B, Ali S, Banerjee S, Wang Z, Logna F, Azmi AS, Kong D, Ahmad A, Li Y, Padhye S and Sarkar FH: Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression. Cancer Res. 72:335–345. 2012. View Article : Google Scholar : PubMed/NCBI

73 

Ali S, Ahmad A, Aboukameel A, Bao B, Padhye S, Philip PA and Sarkar FH: Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells. Cancer Lett. 319:173–181. 2012. View Article : Google Scholar : PubMed/NCBI

74 

Dorai T, Cao YC, Dorai B, Buttyan R and Katz AE: Therapeutic potential of curcumin in human prostate cancer III. Curcumin inhibits proliferation, induces apoptosis and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate. 47:293–303. 2001. View Article : Google Scholar : PubMed/NCBI

75 

Hong JH, Ahn KS, Bae E, Jeon SS and Choi HY: The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo. Prostate Cancer Prostatic Dis. 9:147–152. 2006. View Article : Google Scholar : PubMed/NCBI

76 

Li M, Zhang Z, Hill DL, Wang H and Zhang R: Curcumin, a dietary component, has anticancer, chemosensitization and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Res. 67:1988–1996. 2007. View Article : Google Scholar : PubMed/NCBI

77 

Yallapu MM, Dobberpuhl MR, Maher DM, Jaggi M and Chauhan SC: Design of curcumin loaded cellulose nanoparticles for prostate cancer. Curr Drug Metab. 13:120–128. 2012. View Article : Google Scholar : PubMed/NCBI

78 

Menon LG, Kuttan R and Kuttan G: Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds. Cancer letters. 95:221–225. 1995. View Article : Google Scholar : PubMed/NCBI

79 

Cai YY, Lin WP, Li AP and Xu JY: Combined effects of curcumin and triptolide on an ovarian cancer cell line. Asian Pac J Cancer Prev. 14:4267–4271. 2013. View Article : Google Scholar : PubMed/NCBI

80 

Yang CL, Liu YY, Ma YG, Xue YX, Liu DG, Ren Y, Liu XB, Li Y and Li Z: Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway. PLoS One. 7:e379602012. View Article : Google Scholar : PubMed/NCBI

81 

Tanaka T, Makita H, Ohnishi M, Hirose Y, Wang A, Mori H, Satoh K, Hara A and Ogawa H: Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: Comparison with the protective effect of beta-carotene. Cancer Res. 54:4653–4659. 1994.PubMed/NCBI

82 

Azuine MA and Bhide SV: Adjuvant chemoprevention of experimental cancer: Catechin and dietary turmeric in forestomach and oral cancer models. J Ethnopharmacol. 44:211–217. 1994. View Article : Google Scholar : PubMed/NCBI

83 

Tomren MA, Másson M, Loftsson T and Tønnesen HH: Studies on curcumin and curcuminoids XXXI. Symmetric and asymmetric curcuminoids: Stability, activity and complexation with cyclodextrin. Int J Pharm. 338:27–34. 2007. View Article : Google Scholar : PubMed/NCBI

84 

Chakravarti N, Kadara H, Yoon DJ, Shay JW, Myers JN, Lotan D, Sonenberg N and Lotan R: Differential inhibition of protein translation machinery by curcumin in normal, immortalized and malignant oral epithelial cells. Cancer Prev Res (Phila). 3:331–338. 2010. View Article : Google Scholar : PubMed/NCBI

85 

Chang KW, Hung PS, Lin IY, Hou CP, Chen LK, Tsai YM and Lin SC: Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression. Int J Cancer. 127:9–20. 2010. View Article : Google Scholar : PubMed/NCBI

86 

LoTempio MM, Veena MS, Steele HL, Ramamurthy B, Ramalingam TS, Cohen AN, Chakrabarti R, Srivatsan ES and Wang MB: Curcumin suppresses growth of head and neck squamous cell carcinoma. Clin Cancer Res. 11:6994–7002. 2005. View Article : Google Scholar : PubMed/NCBI

87 

Sandur SK, Deorukhkar A, Pandey MK, Pabón AM, Shentu S, Guha S, Aggarwal BB and Krishnan S: Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. Int J Radiat Oncol Biol Phys. 75:534–542. 2009. View Article : Google Scholar : PubMed/NCBI

88 

Siwak DR, Shishodia S, Aggarwal BB and Kurzrock R: Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of I kappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer. 104:879–890. 2005. View Article : Google Scholar : PubMed/NCBI

89 

Crowell JA, Steele VE and Fay JR: Targeting the AKT protein kinase for cancer chemoprevention. Mol Cancer Ther. 6:2139–2148. 2007. View Article : Google Scholar : PubMed/NCBI

90 

Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, Erfan J, Zabolotnyy D, Kienzer HR, Cupissol D, et al: Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 359:1116–1127. 2008. View Article : Google Scholar : PubMed/NCBI

91 

Aravindan N, Madhusoodhanan R, Ahmad S, Johnson D and Herman TS: Curcumin inhibits NF-kappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells. Cancer Biol Ther. 7:569–576. 2008. View Article : Google Scholar : PubMed/NCBI

92 

Bachmeier BE, Mohrenz IV, Mirisola V, Schleicher E, Romeo F, Höhneke C, Jochum M, Nerlich AG and Pfeffer U: Curcumin downregulates the inflammatory cytokines CXCL1 and −2 in breast cancer cells via NF-kappaB. Carcinogenesis. 29:779–789. 2008. View Article : Google Scholar : PubMed/NCBI

93 

Marin YE, Wall BA, Wang S, Namkoong J, Martino JJ, Suh J, Lee HJ, Rabson AB, Yang CS, Chen S and Ryu JH: Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells. Melanoma Res. 17:274–283. 2007. View Article : Google Scholar : PubMed/NCBI

94 

Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, Ohshiro K and Mori N: Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells. Int J Cancer. 118:765–772. 2006. View Article : Google Scholar : PubMed/NCBI

95 

Wang D, Veena MS, Stevenson K, Tang C, Ho B, Suh JD, Duarte VM, Faull KF, Mehta K, Srivatsan ES and Wang MB: Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Clin Cancer Res. 14:6228–6236. 2008. View Article : Google Scholar : PubMed/NCBI

96 

Khafif A, Lev-Ari S, Vexler A, Barnea I, Starr A, Karaush V, Haif S and Ben-Yosef R: Curcumin: A potential radio-enhancer in head and neck cancer. Laryngoscope. 119:2019–2026. 2009. View Article : Google Scholar : PubMed/NCBI

97 

Jagetia GC: Radioprotection and radiosensitization by curcumin. Adv Exp Med Biol. 595:301–320. 2007. View Article : Google Scholar : PubMed/NCBI

98 

Yallapu MM, Maher DM, Sundram V, Bell MC, Jaggi M and Chauhan SC: Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth. J Ovarian Res. 3:112010. View Article : Google Scholar : PubMed/NCBI

99 

Abuzeid WM, Davis S, Tang AL, Saunders L, Brenner JC, Lin J, Fuchs JR, Light E, Bradford CR, Prince ME and Carey TE: Sensitization of head and neck cancer to cisplatin through the use of a novel curcumin analog. Arch Otolaryngol Head Neck Surg. 137:499–507. 2011. View Article : Google Scholar : PubMed/NCBI

100 

Li N, Chen X, Liao J, Yang G, Wang S, Josephson Y, Han C, Chen J, Huang MT and Yang CS: Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. Carcinogenesis. 23:1307–1313. 2002. View Article : Google Scholar : PubMed/NCBI

101 

Manoharan S, Balakrishnan S, Menon VP, Alias LM and Reena AR: Chemopreventive efficacy of curcumin and piperine during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Singapore Med J. 50:139–146. 2009.PubMed/NCBI

102 

Clark CA, McEachern MD, Shah SH, Rong Y, Rong X, Smelley CL, Caldito GC, Abreo FW and Nathan CO: Curcumin inhibits carcinogen and nicotine-induced Mammalian target of rapamycin pathway activation in head and neck squamous cell carcinoma. Cancer Prev Res (Phila). 3:1586–1595. 2010. View Article : Google Scholar : PubMed/NCBI

103 

Kumar B, Yadav A, Hideg K, Kuppusamy P, Teknos TN and Kumar P: A novel curcumin analog (H-4073) enhances the therapeutic efficacy of cisplatin treatment in head and neck cancer. PloS One. 9:e932082014. View Article : Google Scholar : PubMed/NCBI

104 

Rao CV, Simi B and Reddy BS: Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis. 14:2219–2225. 1993. View Article : Google Scholar : PubMed/NCBI

105 

Hu A, Huang JJ, Jin XJ, Li JP, Tang YJ, Huang XF, Cui HJ, Xu WH and Sun GB: Curcumin suppresses invasiveness and vasculogenic mimicry of squamous cell carcinoma of the larynx through the inhibition of JAK-2/STAT-3 signaling pathway. Am J Cancer Res. 5:278–288. 2014.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Perrone D, Ardito F, Giannatempo G, Dioguardi M, Troiano G, Lo Russo L, De Lillo A, Laino L and Lo Muzio L: Biological and therapeutic activities, and anticancer properties of curcumin (Review). Exp Ther Med 10: 1615-1623, 2015.
APA
Perrone, D., Ardito, F., Giannatempo, G., Dioguardi, M., Troiano, G., Lo Russo, L. ... Lo Muzio, L. (2015). Biological and therapeutic activities, and anticancer properties of curcumin (Review). Experimental and Therapeutic Medicine, 10, 1615-1623. https://doi.org/10.3892/etm.2015.2749
MLA
Perrone, D., Ardito, F., Giannatempo, G., Dioguardi, M., Troiano, G., Lo Russo, L., De Lillo, A., Laino, L., Lo Muzio, L."Biological and therapeutic activities, and anticancer properties of curcumin (Review)". Experimental and Therapeutic Medicine 10.5 (2015): 1615-1623.
Chicago
Perrone, D., Ardito, F., Giannatempo, G., Dioguardi, M., Troiano, G., Lo Russo, L., De Lillo, A., Laino, L., Lo Muzio, L."Biological and therapeutic activities, and anticancer properties of curcumin (Review)". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1615-1623. https://doi.org/10.3892/etm.2015.2749
Copy and paste a formatted citation
x
Spandidos Publications style
Perrone D, Ardito F, Giannatempo G, Dioguardi M, Troiano G, Lo Russo L, De Lillo A, Laino L and Lo Muzio L: Biological and therapeutic activities, and anticancer properties of curcumin (Review). Exp Ther Med 10: 1615-1623, 2015.
APA
Perrone, D., Ardito, F., Giannatempo, G., Dioguardi, M., Troiano, G., Lo Russo, L. ... Lo Muzio, L. (2015). Biological and therapeutic activities, and anticancer properties of curcumin (Review). Experimental and Therapeutic Medicine, 10, 1615-1623. https://doi.org/10.3892/etm.2015.2749
MLA
Perrone, D., Ardito, F., Giannatempo, G., Dioguardi, M., Troiano, G., Lo Russo, L., De Lillo, A., Laino, L., Lo Muzio, L."Biological and therapeutic activities, and anticancer properties of curcumin (Review)". Experimental and Therapeutic Medicine 10.5 (2015): 1615-1623.
Chicago
Perrone, D., Ardito, F., Giannatempo, G., Dioguardi, M., Troiano, G., Lo Russo, L., De Lillo, A., Laino, L., Lo Muzio, L."Biological and therapeutic activities, and anticancer properties of curcumin (Review)". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1615-1623. https://doi.org/10.3892/etm.2015.2749
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team