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Article

Effect of a bioabsorbable, super-high molecular weight poly-D,L-lactic acid plate containing recombinant human bone morphogenetic protein-2 for fracture healing

  • Authors:
    • Ning‑Feng Zhou
    • Yu‑Feng Huang
    • Jin‑Wu Wang
  • View Affiliations / Copyright

    Affiliations: Department of Spinal Surgery, Shanghai East Hospital Affiliated to Shanghai Tongji University, Shanghai 200120, P.R. China, Department of Orthopedics, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200011, P.R. China
  • Pages: 1840-1844
    |
    Published online on: September 17, 2015
       https://doi.org/10.3892/etm.2015.2750
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Abstract

The aim of this study was to investigate the effect of a bioabsorbable, super-high molecular weight poly-D,L-lactic acid (PDLLA) plate exhibiting the sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2) (PDLLA-rhBMP-2) on the treatment of fracture with internal fixation. A total of 32 New Zealand rabbits were randomly allocated to one of four groups (2, 4, 8 and 12 weeks), and a 2.5‑mm middle ulnar osteotomy was performed bilaterally. The right side (experimental side) was fixed internally with PDLLA‑rhBMP‑2, and the left side (control side) was fixed with a normal PDLLA plate. At 2, 4, 8 and 12 weeks after surgery, the gross pathology of the ulnas was examined and radiographic, histological and computer image analyses were performed. The results demonstrated that the ulna fractures were fixed stably with the two bioactive plates at 2, 4, 8 and 12 weeks after surgery. At the 8‑week time‑point, 7 rabbits exhibited good healing at the osteotomy site on the experimental side. At 12 weeks after surgery, 8 rabbits exhibited good healing at the osteotomy site on both sides, but the experimental side showed enhanced compatibility between the plates and surrounding tissue, faster bone formation, a greater bone regeneration mass and better medullary canal structure compared with the control side. In conclusion, PPLLA-rhBMP-2 may be effectively used to treat fracture or nonunion at a non-weight-bearing site.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou NF, Huang YF and Wang JW: Effect of a bioabsorbable, super-high molecular weight poly-D,L-lactic acid plate containing recombinant human bone morphogenetic protein-2 for fracture healing. Exp Ther Med 10: 1840-1844, 2015.
APA
Zhou, N., Huang, Y., & Wang, J. (2015). Effect of a bioabsorbable, super-high molecular weight poly-D,L-lactic acid plate containing recombinant human bone morphogenetic protein-2 for fracture healing. Experimental and Therapeutic Medicine, 10, 1840-1844. https://doi.org/10.3892/etm.2015.2750
MLA
Zhou, N., Huang, Y., Wang, J."Effect of a bioabsorbable, super-high molecular weight poly-D,L-lactic acid plate containing recombinant human bone morphogenetic protein-2 for fracture healing". Experimental and Therapeutic Medicine 10.5 (2015): 1840-1844.
Chicago
Zhou, N., Huang, Y., Wang, J."Effect of a bioabsorbable, super-high molecular weight poly-D,L-lactic acid plate containing recombinant human bone morphogenetic protein-2 for fracture healing". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1840-1844. https://doi.org/10.3892/etm.2015.2750
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou NF, Huang YF and Wang JW: Effect of a bioabsorbable, super-high molecular weight poly-D,L-lactic acid plate containing recombinant human bone morphogenetic protein-2 for fracture healing. Exp Ther Med 10: 1840-1844, 2015.
APA
Zhou, N., Huang, Y., & Wang, J. (2015). Effect of a bioabsorbable, super-high molecular weight poly-D,L-lactic acid plate containing recombinant human bone morphogenetic protein-2 for fracture healing. Experimental and Therapeutic Medicine, 10, 1840-1844. https://doi.org/10.3892/etm.2015.2750
MLA
Zhou, N., Huang, Y., Wang, J."Effect of a bioabsorbable, super-high molecular weight poly-D,L-lactic acid plate containing recombinant human bone morphogenetic protein-2 for fracture healing". Experimental and Therapeutic Medicine 10.5 (2015): 1840-1844.
Chicago
Zhou, N., Huang, Y., Wang, J."Effect of a bioabsorbable, super-high molecular weight poly-D,L-lactic acid plate containing recombinant human bone morphogenetic protein-2 for fracture healing". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1840-1844. https://doi.org/10.3892/etm.2015.2750
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