Effects of mitochondrial haplogroup N9a on type 2 diabetes mellitus and its associated complications

  • Authors:
    • Qing Niu
    • Wanlin Zhang
    • Hailing Wang
    • Xiaomin Guan
    • Jianxin Lu
    • Wei Li
  • View Affiliations

  • Published online on: September 17, 2015     https://doi.org/10.3892/etm.2015.2751
  • Pages: 1918-1924
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Abstract

A case-control study was conducted with the aim of identifying the predominant haplogroups associated with type 2 diabetes mellitus (T2DM) and its complications. In addition, the role of N9a in T2DM risk and complications was analyzed. Sequencing of the entire mitochondrial DNA was conducted in 235 patients and 244 controls in cohort 1, and six haplogroups (F, B4, D4, D5, M8a and N9a) associated with T2DM were classified. The frequency of N9a was further determined in cohort 2 (440 patients and 244 controls) and examined in two combined cohorts, including 675 patients with T2DM and 649 non‑diabetic controls. Multivariate logistic regression analysis and association analysis were performed to investigate the association between genotypes, T2DM and diabetic nephropathy. M8a [P=0.011; odds ratio (OR), 3.49; 95% confidence interval (CI), 1.26‑9.69] and haplogroup N9a (P=0.023; OR, 2.60; 95% CI, 1.11‑6.05) were associated with an increased risk of T2DM. The frequency of N9a was higher in T2DM patients compared with that in the controls (6.2% vs. 4.3%) and associated with a mild risk (P=0.10; OR, 1.51; 95% CI, 0.92‑2.49). N9a was significantly associated with an increased risk of diabetic nephropathy (P=0.024; OR, 2.15; 95% CI, 1.11‑4.19). Previous findings of N9a being protective against T2DM were not replicated in the present study, although this haplogroup was associated with an increased risk of diabetic nephropathy.
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November-2015
Volume 10 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Niu Q, Zhang W, Wang H, Guan X, Lu J and Li W: Effects of mitochondrial haplogroup N9a on type 2 diabetes mellitus and its associated complications. Exp Ther Med 10: 1918-1924, 2015
APA
Niu, Q., Zhang, W., Wang, H., Guan, X., Lu, J., & Li, W. (2015). Effects of mitochondrial haplogroup N9a on type 2 diabetes mellitus and its associated complications. Experimental and Therapeutic Medicine, 10, 1918-1924. https://doi.org/10.3892/etm.2015.2751
MLA
Niu, Q., Zhang, W., Wang, H., Guan, X., Lu, J., Li, W."Effects of mitochondrial haplogroup N9a on type 2 diabetes mellitus and its associated complications". Experimental and Therapeutic Medicine 10.5 (2015): 1918-1924.
Chicago
Niu, Q., Zhang, W., Wang, H., Guan, X., Lu, J., Li, W."Effects of mitochondrial haplogroup N9a on type 2 diabetes mellitus and its associated complications". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1918-1924. https://doi.org/10.3892/etm.2015.2751