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Article

A modified ultra-long pituitary downregulation protocol improved endometrial receptivity and clinical outcome for infertile patients with polycystic ovarian syndrome

  • Authors:
    • Fei Gong
    • Xihong Li
    • Shunji Zhang
    • Hainan Ma
    • Sufen Cai
    • Juan Li
    • Ge Lin
    • Guangxiu Lu
  • View Affiliations / Copyright

    Affiliations: Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, Hunan 410083, P.R. China, Department of Reproductive Medicine, Reproductive and Genetic Hospital of Citic‑Xiangya, Changsha, Hunan 410078, P.R. China
  • Pages: 1865-1870
    |
    Published online on: September 23, 2015
       https://doi.org/10.3892/etm.2015.2769
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Abstract

There are currently various protocols for in vitro fertilization (IVF). For patients with polycystic ovarian syndrome (PCOS), an optimized protocol for the downregulation of pituitary follicle stimulating hormone and luteinizing hormone via gonadotropin‑releasing hormone agonist (GnRHa) remains a challenge. In the present study, the primary endpoint of an ultra‑long and a conventional long GnRHa protocol for intracytoplasmic sperm injection/IVF treatments of patients with PCOS was retrospectively compared. In the modified ultra‑long protocol group, endometrial thickness, morphology, and blood flow were significantly improved, as compared with in the conventional long protocol group. Furthermore, the serum progestogen (P) concentrations and P/estrogen (E2) [(Px1,000/E2)] ratio on the day of human chorionic gonadotrophin administration were significantly decreased in the modified ultra‑long downregulation group, whereas the pregnancy and implantation rates were significantly higher. There were no significant differences in the average number of obtained oocytes, good quality embryo rates, cancel rates, fertilization rates, abortion rates, serious ovarian hyperstimulation syndrome incidences, ectopic pregnancy rates or gonadotropin (Gn) dosages between the two groups. These results suggest that the modified ultra‑long protocol plus human menopausal Gn medication may be superior to the conventional long protocol, and may lead to improved implantation and pregnancy outcomes for infertile patients with PCOS.
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1 

Sheehan MT: Polycystic ovarian syndrome: Diagnosis and management. Clin Med Res. 2:13–27. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Hart R: Polycystic ovarian syndrome - prognosis and treatment outcomes. Curr Opin Obstet Gynecol. 19:529–535. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Chen ZJ and Shi Y: Polycystic ovary syndrome. Front Med China. 4:280–284. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Elnashar AM: Progesterone rise on the day of HCG administration (premature luteinization) in IVF: An overdue update. J Assist Reprod Genet. 27:149–155. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Pundir J, Sunkara SK, El-Toukhy T and Khalaf Y: Meta-analysis of GnRH antagonist protocols: Do they reduce the risk of OHSS in PCOS? Reprod Biomed Online. 24:6–22. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Orvieto R, Meltcer S, Liberty G, Rabinson J, Anteby EY and Nahum R: Does day-3 LH/FSH ratio influence in vitro fertilization outcome in PCOS patients undergoing controlled ovarian hyperstimulation with different GnRH-analogue? Gynecol Endocrinol. 28:422–424. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Rickes D, Nickel I, Kropf S and Kleinstein J: Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis. Fertil Steril. 78:757–762. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Surrey ES, Silverberg KM, Surrey MW and Schoolcraft WB: Effect of prolonged gonadotropin-releasing hormone agonist therapy on the outcome of in vitro fertilization-embryo transfer in patients with endometriosis. Fertil Steril. 78:699–704. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Mijatovic V, Florijn E, Halim N, Schats R and Hompes P: Adenomyosis has no adverse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI. Eur J Obstet Gynecol Reprod Biol. 151:62–65. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 19:41–47. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Alper MM, Brinsden PR, Fischer R and Wikland M: Is your IVF programme good? Hum Reprod. 17:8–10. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Gonen Y and Casper RF: Prediction of implantation by the sonographic appearance of the endometrium during controlled ovarian stimulation for in vitro fertilization (IVF). J In Vitro Fert Embryo Transf. 7:146–152. 1990. View Article : Google Scholar : PubMed/NCBI

13 

Chien LW, Au HK, Chen PL, Xiao J and Tzeng CR: Assessment of uterine receptivity by the endometrial-subendometrial blood flow distribution pattern in women undergoing in vitro fertilization-embryo transfer. Fertil Steril. 78:245–251. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Bosch E, Valencia I, Escudero E, Crespo J, Simón C, Remohí J and Pellicer A: Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome. Fertil Steril. 80:1444–1449. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Elgindy EA: Progesterone level and progesterone/estradiol ratio on the day of hCG administration: Detrimental cutoff levels and new treatment strategy. Fertil Steril. 95:1639–1644. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Wu Z, Li R, Ma Y, Deng B, Zhang X, Meng Y, Chen X, Liu P and Qiao J: Effect of HCG-day serum progesterone and oestradiol concentrations on pregnancy outcomes in GnRH agonist cycles. Reprod Biomed Online. 24:511–520. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Papanikolaou EG, Pados G, Grimbizis G, Bili E, Kyriazi L, Polyzos NP, Humaidan P, Tournaye H and Tarlatzis B: GnRH-agonist versus GnRH-antagonist IVF cycles: Is the reproductive outcome affected by the incidence of progesterone elevation on the day of HCG triggering? A randomized prospective study. Hum Reprod. 27:1822–1828. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Venetis CA, Kolibianakis EM, Bosdou JK and Tarlatzis BC: Progesterone elevation and probability of pregnancy after IVF: A systematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update. 19:433–457. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Humaidan P, Bungum L, Bungum M and Andersen CY: Ovarian response and pregnancy outcome related to mid-follicular LH levels in women undergoing assisted reproduction with GnRH agonist down-regulation and recombinant FSH stimulation. Hum Reprod. 17:2016–2021. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Sharara FI, Lim J and McClamrock HD: Endometrial pattern on the day of oocyte retrieval is more predictive of implantation success than the pattern or thickness on the day of hCG administration. J Assist Reprod Genet. 16:523–528. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Zhang X, Chen CH, Confino E, Barnes R, Milad M and Kazer RR: Increased endometrial thickness is associated with improved treatment outcome for selected patients undergoing in vitro fertilization-embryo transfer. Fertil Steril. 83:336–340. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Järvelä IY, Sladkevicius P, Kelly S, Ojha K, Campbell S and Nargund G: Evaluation of endometrial receptivity during in-vitro fertilization using three-dimensional power Doppler ultrasound. Ultrasound Obstet Gynecol. 26:765–769. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Kinay T, Tasci Y, Dilbaz S, Cinar O, Demir B and Haberal A: The relationship between endometrial thickness and pregnancy rates in GnRH antagonist down-regulated ICSI cycles. Gynecol Endocrinol. 26:833–837. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Okohue JE, Onuh SO, Ebeigbe P, Shaibu I, Wada I, Ikimalo JI and Okpere EE: The effect of endometrial thickness on in vitro fertilization (IVF)-embryo transfer/intracytoplasmic sperm injection (ICSI) outcome. Afr J Reprod Health. 13:113–121. 2009.PubMed/NCBI

25 

Rashidi BH, Sadeghi M, Jafarabadi M and Tehrani Nejad ES: Relationships between pregnancy rates following in vitro fertilization or intracytoplasmic sperm injection and endometrial thickness and pattern. Eur J Obstet Gynecol Reprod Biol. 120:179–184. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Traub ML, Van Arsdale A, Pal L, Jindal S and Santoro N: Endometrial thickness, Caucasian ethnicity, and age predict clinical pregnancy following fresh blastocyst embryo transfer: A retrospective cohort. Reprod Biol Endocrinol. 7:332009. View Article : Google Scholar : PubMed/NCBI

27 

Lintsen AM, Pasker-de Jong PC, de Boer EJ, Burger CW, Jansen CA, Braat DD and van Leeuwen FE: Effects of subfertility cause, smoking and body weight on the success rate of IVF. Hum Reprod. 20:1867–1875. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Raine-Fenning NJ, Campbell BK, Kendall NR, Clewes JS and Johnson IR: Quantifying the changes in endometrial vascularity throughout the normal menstrual cycle with three-dimensional power Doppler angiography. Hum Reprod. 19:330–338. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Jungheim ES, Lanzendorf SE, Odem RR, Moley KH, Chang AS and Ratts VS: Morbid obesity is associated with lower clinical pregnancy rates after in vitro fertilization in women with polycystic ovary syndrome. Fertil Steril. 92:256–261. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Metwally M, Cutting R, Tipton A, Skull J, Ledger WL and Li TC: Effect of increased body mass index on oocyte and embryo quality in IVF patients. Reprod Biomed Online. 15:532–538. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Sneed ML, Uhler ML, Grotjan HE, Rapisarda JJ, Lederer KJ and Beltsos AN: Body mass index: Impact on IVF success appears age-related. Hum Reprod. 23:1835–1839. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gong F, Li X, Zhang S, Ma H, Cai S, Li J, Lin G and Lu G: A modified ultra-long pituitary downregulation protocol improved endometrial receptivity and clinical outcome for infertile patients with polycystic ovarian syndrome. Exp Ther Med 10: 1865-1870, 2015.
APA
Gong, F., Li, X., Zhang, S., Ma, H., Cai, S., Li, J. ... Lu, G. (2015). A modified ultra-long pituitary downregulation protocol improved endometrial receptivity and clinical outcome for infertile patients with polycystic ovarian syndrome. Experimental and Therapeutic Medicine, 10, 1865-1870. https://doi.org/10.3892/etm.2015.2769
MLA
Gong, F., Li, X., Zhang, S., Ma, H., Cai, S., Li, J., Lin, G., Lu, G."A modified ultra-long pituitary downregulation protocol improved endometrial receptivity and clinical outcome for infertile patients with polycystic ovarian syndrome". Experimental and Therapeutic Medicine 10.5 (2015): 1865-1870.
Chicago
Gong, F., Li, X., Zhang, S., Ma, H., Cai, S., Li, J., Lin, G., Lu, G."A modified ultra-long pituitary downregulation protocol improved endometrial receptivity and clinical outcome for infertile patients with polycystic ovarian syndrome". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1865-1870. https://doi.org/10.3892/etm.2015.2769
Copy and paste a formatted citation
x
Spandidos Publications style
Gong F, Li X, Zhang S, Ma H, Cai S, Li J, Lin G and Lu G: A modified ultra-long pituitary downregulation protocol improved endometrial receptivity and clinical outcome for infertile patients with polycystic ovarian syndrome. Exp Ther Med 10: 1865-1870, 2015.
APA
Gong, F., Li, X., Zhang, S., Ma, H., Cai, S., Li, J. ... Lu, G. (2015). A modified ultra-long pituitary downregulation protocol improved endometrial receptivity and clinical outcome for infertile patients with polycystic ovarian syndrome. Experimental and Therapeutic Medicine, 10, 1865-1870. https://doi.org/10.3892/etm.2015.2769
MLA
Gong, F., Li, X., Zhang, S., Ma, H., Cai, S., Li, J., Lin, G., Lu, G."A modified ultra-long pituitary downregulation protocol improved endometrial receptivity and clinical outcome for infertile patients with polycystic ovarian syndrome". Experimental and Therapeutic Medicine 10.5 (2015): 1865-1870.
Chicago
Gong, F., Li, X., Zhang, S., Ma, H., Cai, S., Li, J., Lin, G., Lu, G."A modified ultra-long pituitary downregulation protocol improved endometrial receptivity and clinical outcome for infertile patients with polycystic ovarian syndrome". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1865-1870. https://doi.org/10.3892/etm.2015.2769
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