Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis

Wang,Jifeng; Ji,Wenli; Xu,Zhengqin; Pan,Tao

doi:10.3892/etm.2015.2863

Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis

Authors:
- Jifeng Wang
- Wenli Ji
- Zhengqin Xu
- Tao Pan
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Affiliations: Department of Intensive Care Medicine, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China
Published online on: November 12, 2015 https://doi.org/10.3892/etm.2015.2863
Pages: 154-156
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sepsis is a systemic inflammatory response of the body to an antigen and can become a life-threatening condition by triggering a cascade of changes leading to multiple organ failure such as heart failure. The aim of the present study was to examine the changes of the plasma levels of N‑terminal of the prohormone brain natriuretic peptide (NT‑proBNP) and cardiac troponin T (cTnT) in patients with sepsis and to analyze their prognostic significance. A total of 38 hospitalized patients with sepsis were included in the present study. The patients were divided into the survival and death groups, based on their prognosis. The plasma levels of NT‑proBNP and cTnT for the two groups were measured for all the patients on the 1st, 3rd and 7th day of admission. The plasma levels of NT‑proBNP and cTnT between the two groups were compared and their association with prognosis were analyzed. The plasma levels of NT‑proBNP and cTnT in the death group were significantly higher than those in the survival group (P<0.05). Additionally, a positive assocciation of the plasma levels of NT-proBNP and cTnT was identified (P<0.05). In conclusion, the plasma levels of NT-proBNP and cTnT may be used as routine clinical biomarkers to assess the prognosis of patients with sepsis.

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