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Case Report Open Access

Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report

  • Authors:
    • Daniela Bettio
    • Anna Venci
    • Valentina Achille
    • Marco Alloisio
    • Armando Santoro
  • View Affiliations / Copyright

    Affiliations: Cytogenetic and Medical Genetic Laboratory, Operative Unit of Clinical Investigations, Humanitas Clinical and Research Center, Milan I‑20089, Italy, Department of Thoracic Surgery, Humanitas Clinical and Research Center, Milan I‑20089, Italy, Department of Oncology and Hematology, Humanitas Cancer Center, Humanitas Clinical and Research Center, Milan I‑20089, Italy
    Copyright: © Bettio et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 98-100
    |
    Published online on: November 16, 2015
       https://doi.org/10.3892/etm.2015.2870
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Abstract

The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi-step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array‑comparative genomic hybridization (a‑CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a‑CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi-step carcinogenic process in the lung.
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1 

Kitamura H, Kameda Y, Ito T and Hayashi H: Atypical adenomatous hyperplasia of the lung. Implications for the pathogenesis of peripheral lung adenocarcinoma. Am J Clin Pathol. 111:610–622. 1999.PubMed/NCBI

2 

Henschke CI, Yankelevitz DF, Mirtcheva R, McGuinness G, McCauley D and Miettinen OS: ELCAP Group: CT screening for lung cancer: Frequency and significance of part-solid and nonsolid nodules. AJR Am J Roentgenol. 178:1053–1057. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Nakata M, Saeki H, Takata I, Segawa Y, Mogami H, Mandai K and Eguchi K: Focal ground-glass opacity detected by low-dose helical CT. Chest. 121:1464–1467. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Morandi L, Asioli S, Cavazza A, Pession A and Damiani S: Genetic relationship among atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and adenocarcinoma of the lung. Lung Cancer. 56:35–42. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Kerr KM, Carey FA, King G and Lamb D: Atypical alveolar hyperplasia: Relationship with pulmonary adenocarcinoma, p53, and c-erbB-2 expression. J Pathol. 174:249–256. 1994. View Article : Google Scholar : PubMed/NCBI

6 

Tomida S, Yatabe Y, Yanagisawa K, Mitsudomi T and Takahashi T: Throwing new light on lung cancer pathogenesis: Updates on three recent topics. Cancer Sci. 96:63–68. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Sano T, Kitayama Y, Igarashi H, Suzuki M, Tanioka F, Chida K, Okudela K and Sugimura H: Chromosomal numerical abnormalities in early stage lung adenocarcinoma. Pathol Int. 56:117–125. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Bettio D, Cariboni U, Venci A, Valente M, Spaggiari P and Alloisio M: Cytogenetic findings in lung cancer that illuminate its biological history from adenomatous hyperplasia to bronchioalveolar carcinoma to adenocarcinoma: A case report. Exp Ther Med. 4:1032–1034. 2012.PubMed/NCBI

9 

Bettio D, Rizzi N, Giardino D, Persani L, Pecori-Giraldi F, Losa M and Larizza L: Cytogenetic study of pituitary adenomas. Cancer Genet Cytogenet. 98:131–136. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Genome Bioinformatics Group of University of California Santa Cruz: UCSC genome browser. http://genome.ucsc.edu/cgi-bin/hgGatewayAccessed. November 14–2014

11 

Heighway J and Betticher DC: Lung: Non-small cell carcinoma. Atlas of Genetics and Cytogenetics in Oncology and Haematology. http://atlasgeneticsoncology.org/Tumors/LungNonSmallCellID5141.htmlAccessed. November 04–2014PubMed/NCBI

12 

Demopoulos K, Arvanitis DA, Vassilakis DA, Siafakas NM and Spandidos DA: MYCL1, FHIT, SPARC, p16 (INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis. J Cell Mol Med. 6:215–222. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Li MY, Lai PL, Chou YT, Chi AP, Mi YZ, Khoo KH, Chang GD, Wu CW, Meng TC and Chen GC: Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation. Oncogene. 34:3791–3803. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Liu X, Su L and Liu X: Loss of CDH1 up-regulates epidermal growth factor receptor via phosphorylation of YBX1 in non-small cell lung cancer cells. FEBS Lett. 587:3995–4000. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Yun HM, Park KR, Lee HP, Lee DH, Jo M, Shin DH, Yoon DY, Han SB and Hong JT: PRDX6 promotes lung tumor progression via its GPx and iPLA2 activities. Free Radic Biol Med. 69:367–376. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Testa JR and Siegfried JM: Chromosome abnormalities in human non-small cell lung cancer. Cancer Res. 52(9 Suppl): 2702s–2706s. 1992.PubMed/NCBI

17 

Li J, Bi L, Sun Y, Lu Z, Lin Y, Bai O and Shao H: Text mining and network analysis of molecular interaction in non-small cell lung cancer by using natural language processing. Mol Biol Rep. 41:8071–8079. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Panani AD, Maliaga K, Babanaraki A and Bellenis I: Numerical abnormalities of chromosome 9 and p16CDKN2A gene deletion detected by FISH in non-small cell lung cancer. Anticancer Res. 29:4483–4487. 2009.PubMed/NCBI

19 

Oyanagi H, Takenaka K, Ishikawa S, Kawano Y, Adachi Y, Ueda K, Wada H and Tanaka F: Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer. Lung Cancer. 46:21–28. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Meng X, Lu P, Bai H, Xiao P and Fan Q: Transcriptional regulatory networks in human lung adenocarcinoma. Mol Med Rep. 6:961–966. 2012.PubMed/NCBI

21 

Testa JR, Liu Z, Feder M, Bell DW, Balsara B, Cheng JQ and Taguchi T: Advances in the analysis of chromosome alterations in human lung carcinomas. Cancer Genet Cytogenet. 95:20–32. 1997. View Article : Google Scholar : PubMed/NCBI

22 

González-Sánchez E, Martín-Caballero J, Flores JM, Hernández-Losa J, Ángeles Ma Montero, Cortés J, Mares R, Barbacid M and Recio JA: Lkb1 loss promotes tumor progression of BRAF (V600E)-induced lung adenomas. PLoS One. 8:e669332013. View Article : Google Scholar : PubMed/NCBI

23 

Clark J, Freeman J and Donninger H: Loss of RASSF2 enhances tumorigencity of lung cancer cells and confers resistance to chemotherapy. Mol Biol Int. 2012:7059482012. View Article : Google Scholar : PubMed/NCBI

24 

Papay J, Krenacs T, Moldvay J, Stelkovics E, Furak J, Molnar B and Kopper L: Immunophenotypic profiling of nonsmall cell lung cancer progression using the tissue microarray approach. Appl Immunohistochem Mol Morphol. 15:19–30. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Kitaguchi S, Takeshima Y, Nishisaka T and Inai K: Proliferative activity, p53 expression and loss of heterozygosity on 3p, 9p and 17p in atypical adenomatous hyperplasia of the lung. Hiroshima J Med Sci. 47:17–25. 1998.PubMed/NCBI

26 

Kohno H, Hiroshima K, Toyozaki T, Fujisawa T and Ohwada H: p53 mutation and allelic loss of chromosome 3p, 9p of preneoplastic lesions in patients with nonsmall cell lung carcinoma. Cancer. 85:341–347. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Yamasaki M, Takeshima Y, Fujii S, Kitaguchi S, Matsuura M, Tagawa K and Inai K: Correlation between genetic alterations and histopathological subtypes in bronchiolo-alveolar carcinoma and atypical adenomatous hyperplasia of the lung. Pathol Int. 50:778–785. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bettio D, Venci A, Achille V, Alloisio M and Santoro A: Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report. Exp Ther Med 11: 98-100, 2016.
APA
Bettio, D., Venci, A., Achille, V., Alloisio, M., & Santoro, A. (2016). Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report. Experimental and Therapeutic Medicine, 11, 98-100. https://doi.org/10.3892/etm.2015.2870
MLA
Bettio, D., Venci, A., Achille, V., Alloisio, M., Santoro, A."Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report". Experimental and Therapeutic Medicine 11.1 (2016): 98-100.
Chicago
Bettio, D., Venci, A., Achille, V., Alloisio, M., Santoro, A."Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report". Experimental and Therapeutic Medicine 11, no. 1 (2016): 98-100. https://doi.org/10.3892/etm.2015.2870
Copy and paste a formatted citation
x
Spandidos Publications style
Bettio D, Venci A, Achille V, Alloisio M and Santoro A: Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report. Exp Ther Med 11: 98-100, 2016.
APA
Bettio, D., Venci, A., Achille, V., Alloisio, M., & Santoro, A. (2016). Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report. Experimental and Therapeutic Medicine, 11, 98-100. https://doi.org/10.3892/etm.2015.2870
MLA
Bettio, D., Venci, A., Achille, V., Alloisio, M., Santoro, A."Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report". Experimental and Therapeutic Medicine 11.1 (2016): 98-100.
Chicago
Bettio, D., Venci, A., Achille, V., Alloisio, M., Santoro, A."Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report". Experimental and Therapeutic Medicine 11, no. 1 (2016): 98-100. https://doi.org/10.3892/etm.2015.2870
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