Open Access

Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report

  • Authors:
    • Daniela Bettio
    • Anna Venci
    • Valentina Achille
    • Marco Alloisio
    • Armando Santoro
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  • Published online on: November 16, 2015     https://doi.org/10.3892/etm.2015.2870
  • Pages: 98-100
  • Copyright: © Bettio et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi-step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array‑comparative genomic hybridization (a‑CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a‑CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi-step carcinogenic process in the lung.
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January-2016
Volume 11 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Bettio D, Venci A, Achille V, Alloisio M and Santoro A: Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report. Exp Ther Med 11: 98-100, 2016
APA
Bettio, D., Venci, A., Achille, V., Alloisio, M., & Santoro, A. (2016). Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report. Experimental and Therapeutic Medicine, 11, 98-100. https://doi.org/10.3892/etm.2015.2870
MLA
Bettio, D., Venci, A., Achille, V., Alloisio, M., Santoro, A."Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report". Experimental and Therapeutic Medicine 11.1 (2016): 98-100.
Chicago
Bettio, D., Venci, A., Achille, V., Alloisio, M., Santoro, A."Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report". Experimental and Therapeutic Medicine 11, no. 1 (2016): 98-100. https://doi.org/10.3892/etm.2015.2870