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Article

Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients

  • Authors:
    • Xiaoyan Zhang
    • Ruilan Wang
    • Jian Lu
    • Wei Jin
    • Yongbin Qian
    • Peijie Huang
    • Rui Tian
    • Yan Li
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200080, P.R. China
  • Pages: 360-366
    |
    Published online on: November 17, 2015
       https://doi.org/10.3892/etm.2015.2872
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Abstract

The aim of the present study was to observe and compare the sedative effect of different doses of DEX on heart rate (HR) and blood pressure (BP) in critically ill patients admitted to intensive care units (ICUs). The study included patients that were retained in ICUs and required sedation between January and March 2014. Patients were excluded if they had a BP of >200 mmHg, a HR of <60 bpm or were in a state of shock. The included patients were randomized into three groups: Group A, 1.0 µg/kg/10 min DEX; group B, 0.5 µg/kg/10 min DEX; and group C, 0.4 µg/kg/h DEX. After receiving these initial designated doses of DEX via an intravenous (IV) infusion pump for 10 min, the patients were maintained continuously at an identical dose of 0.4 µg/kg/h DEX. Ramsay score, HR, systolic blood pressure (SBP), diastolic blood pressure (DBP), breathing rate (BR) and peripheral capillary oxygen saturation (SpO2) were recorded prior to the IV pump infusion and at 2, 4, 6, 8, 10, 60, 120, 180 and 240 min following infusion. Patients in groups A and B achieved sedation more rapidly compared with those in group C (P<0.05). HR decreased more significantly at 8 and 60 min after the initial IV pump infusion with DEX in groups A and B compared with group C (P<0.05). SBP decreased significantly at 10 min after IV pump infusion in group A compared with groups B and C (P<0.05). No significant difference existed in the SBP reduction trend between the three groups during the maintenance period. Therefore, the routine dose of DEX (0.4 µg/kg/h) provides an ideal sedative effect in ICU patients. The recommended loading dose for a more rapid sedation is 0.5 µg/kg/h. High loading doses of DEX via IV pump infusion should be avoided in elderly individuals, patients with acute exacerbation of chronic obstructive pulmonary disease and anemic patients, in whom combination medication, such as midazolam or propofol, may be considered when necessary.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Wang R, Lu J, Jin W, Qian Y, Huang P, Tian R and Li Y: Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients. Exp Ther Med 11: 360-366, 2016.
APA
Zhang, X., Wang, R., Lu, J., Jin, W., Qian, Y., Huang, P. ... Li, Y. (2016). Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients. Experimental and Therapeutic Medicine, 11, 360-366. https://doi.org/10.3892/etm.2015.2872
MLA
Zhang, X., Wang, R., Lu, J., Jin, W., Qian, Y., Huang, P., Tian, R., Li, Y."Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients". Experimental and Therapeutic Medicine 11.1 (2016): 360-366.
Chicago
Zhang, X., Wang, R., Lu, J., Jin, W., Qian, Y., Huang, P., Tian, R., Li, Y."Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients". Experimental and Therapeutic Medicine 11, no. 1 (2016): 360-366. https://doi.org/10.3892/etm.2015.2872
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Wang R, Lu J, Jin W, Qian Y, Huang P, Tian R and Li Y: Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients. Exp Ther Med 11: 360-366, 2016.
APA
Zhang, X., Wang, R., Lu, J., Jin, W., Qian, Y., Huang, P. ... Li, Y. (2016). Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients. Experimental and Therapeutic Medicine, 11, 360-366. https://doi.org/10.3892/etm.2015.2872
MLA
Zhang, X., Wang, R., Lu, J., Jin, W., Qian, Y., Huang, P., Tian, R., Li, Y."Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients". Experimental and Therapeutic Medicine 11.1 (2016): 360-366.
Chicago
Zhang, X., Wang, R., Lu, J., Jin, W., Qian, Y., Huang, P., Tian, R., Li, Y."Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients". Experimental and Therapeutic Medicine 11, no. 1 (2016): 360-366. https://doi.org/10.3892/etm.2015.2872
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