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Article

Dynamic contrast-enhanced MRI serves as a predictor of HIFU treatment outcome for uterine fibroids with hyperintensity in T2-weighted images

  • Authors:
    • Wen‑Peng Zhao
    • Jin‑Yun Chen
    • Wen‑Zhi Chen
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Ultrasound Engineering in Medicine Co‑founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, P.R. China
  • Pages: 328-334
    |
    Published online on: November 18, 2015
       https://doi.org/10.3892/etm.2015.2879
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Abstract

The aim of the present study was to investigate the efficacy of dynamic contrast‑enhanced magnetic resonance imaging (MRI) in predicting the outcome of using ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation for the treatment of uterine fibroids with T2 hyperintensity under MRI. A total of 131 uterine fibroids from 131 patients that appeared hyperintense under T2‑weighted MRI were analyzed. The uterine fibroids were subjectively categorized into slight, irregular or regular enhancement groups, according to pretreatment dynamic contrast‑enhanced MRI in the arterial phase within 60 sec after the injection of gadolinium. The non‑perfused volume (NPV), which is indicative of successful ablation, was represented as the non‑perfused area inside the uterine fibroids on enhanced MRI scans following treatment. Additionally, the treatment duration, treatment efficiency, sonication duration, energy efficiency ratio and any adverse events were recorded. The results indicated that the average NPV ratio for all the treated fibroids was 68.5%, while the average NPV ratios for fibroids with slight, irregular or regular enhancement were 84.7, 70.6 and 57.1%, respectively. Fibroids with regular enhancement were associated with the lowest NPV ratio and the lowest treatment efficiency, but exhibited the highest energy effect ratio and an elevated risk of severe adverse effects. The results of the present study indicate that hyperintense uterine fibroids with slight and irregular enhancement in the arterial phase of dynamic contrast‑enhanced MRI are suitable for USgHIFU treatment. By contrast, uterine fibroids with regular enhancement were associated with the lowest treatment efficacy and safety.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao WP, Chen JY and Chen WZ: Dynamic contrast-enhanced MRI serves as a predictor of HIFU treatment outcome for uterine fibroids with hyperintensity in T2-weighted images. Exp Ther Med 11: 328-334, 2016.
APA
Zhao, W., Chen, J., & Chen, W. (2016). Dynamic contrast-enhanced MRI serves as a predictor of HIFU treatment outcome for uterine fibroids with hyperintensity in T2-weighted images. Experimental and Therapeutic Medicine, 11, 328-334. https://doi.org/10.3892/etm.2015.2879
MLA
Zhao, W., Chen, J., Chen, W."Dynamic contrast-enhanced MRI serves as a predictor of HIFU treatment outcome for uterine fibroids with hyperintensity in T2-weighted images". Experimental and Therapeutic Medicine 11.1 (2016): 328-334.
Chicago
Zhao, W., Chen, J., Chen, W."Dynamic contrast-enhanced MRI serves as a predictor of HIFU treatment outcome for uterine fibroids with hyperintensity in T2-weighted images". Experimental and Therapeutic Medicine 11, no. 1 (2016): 328-334. https://doi.org/10.3892/etm.2015.2879
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao WP, Chen JY and Chen WZ: Dynamic contrast-enhanced MRI serves as a predictor of HIFU treatment outcome for uterine fibroids with hyperintensity in T2-weighted images. Exp Ther Med 11: 328-334, 2016.
APA
Zhao, W., Chen, J., & Chen, W. (2016). Dynamic contrast-enhanced MRI serves as a predictor of HIFU treatment outcome for uterine fibroids with hyperintensity in T2-weighted images. Experimental and Therapeutic Medicine, 11, 328-334. https://doi.org/10.3892/etm.2015.2879
MLA
Zhao, W., Chen, J., Chen, W."Dynamic contrast-enhanced MRI serves as a predictor of HIFU treatment outcome for uterine fibroids with hyperintensity in T2-weighted images". Experimental and Therapeutic Medicine 11.1 (2016): 328-334.
Chicago
Zhao, W., Chen, J., Chen, W."Dynamic contrast-enhanced MRI serves as a predictor of HIFU treatment outcome for uterine fibroids with hyperintensity in T2-weighted images". Experimental and Therapeutic Medicine 11, no. 1 (2016): 328-334. https://doi.org/10.3892/etm.2015.2879
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