Effect of the topical application of calcipotriol on the expression levels of zinc finger protein A20 and nuclear factor‑κB in the skin lesions of patients with psoriasis vulgaris

Tang,Ya‑Juan; Zhang,Ru‑Zhi; Liu,Xiao‑Ming; Xu,Chun‑Xing; Cheng,Sai; Liu,Qi

doi:10.3892/etm.2015.2887

January-2016 Volume 11 Issue 1

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January-2016 Volume 11 Issue 1

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Article

Effect of the topical application of calcipotriol on the expression levels of zinc finger protein A20 and nuclear factor‑κB in the skin lesions of patients with psoriasis vulgaris

Authors:
- Ya‑Juan Tang
- Ru‑Zhi Zhang
- Xiao‑Ming Liu
- Chun‑Xing Xu
- Sai Cheng
- Qi Liu
View Affiliations / Copyright

Affiliations: Department of Dermatology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China
Pages: 247-250
|
Published online on: November 24, 2015

https://doi.org/10.3892/etm.2015.2887
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Abstract

The aim of the present study was to explore the effect of the topical application of calcipotriol on the expression levels of zinc finger protein A20 and nuclear factor‑κB (NF‑κB) in the skin lesions of patients with psoriasis vulgaris. The calcipotriol ointment was topically applied twice a day for 6 weeks by 26 patients with psoriasis vulgaris. At the end of weeks 2, 4 and 6 after the first application of calcipotriol ointment, the clinical efficacy and Psoriasis Area and Severity Index (PASI) score were compared with those prior to treatment. The expression of zinc finger protein A20 and NF‑κB in the skin lesions prior to and following treatment with calcipotriol was measured by immunohistochemical staining and western blotting. At the end of week 6, the clinical effectiveness rate of calcipotriol was higher compared with that at the end of weeks 2 and 4 (χ2=8.12 and 9.06, respectively; P<0.05). The PASI score declined significantly at the end of weeks 2, 4 and 6 (t=9.37, 10.54 and 12.43; P<0.05, 0.05 and 0.001, respectively). At the end of week 6, the expression levels of zinc finger protein A20 and NF‑κB were significantly lower compared with those prior to treatment (χ2=3.65 and 4.17, respectively; P<0.01). The expression levels of the two proteins were higher in the skin lesions of patients with psoriasis vulgaris prior to the initiation of treatment than in the skin of a normal control group. Following the 6‑week treatment with calcipotriol, the expression levels of the two proteins in the psoriasis skin lesions were significantly lower than they were prior to treatment (P<0.01). Thus, the present study found that in addition to the typical pathway of NF‑κB being targeted in the treatment of psoriasis with calcipotriol, the zinc finger protein A20 may also modulate the inflammatory response of psoriasis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of the topical application of calcipotriol on the expression levels of zinc finger protein A20 and nuclear factor‑κB in the skin lesions of patients with psoriasis vulgaris

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