Pyogenic granuloma in a patient with psoriasis successfully treated by 5-aminolevulinic acid photodynamic therapy: A case report

Liu,Juan; Zhou,Bing‑Rong; Yi,Fei; Wu,Hong‑Jin; Zhang,Jia‑An; Luo,Dan

doi:10.3892/etm.2015.2899

January-2016 Volume 11 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

January-2016 Volume 11 Issue 1

Full Size Image

Case Report

Pyogenic granuloma in a patient with psoriasis successfully treated by 5-aminolevulinic acid photodynamic therapy: A case report

Authors:
- Juan Liu
- Bing‑Rong Zhou
- Fei Yi
- Hong‑Jin Wu
- Jia‑An Zhang
- Dan Luo
View Affiliations / Copyright

Affiliations: Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
Pages: 345-347
|
Published online on: November 27, 2015

https://doi.org/10.3892/etm.2015.2899
Expand metrics +

Abstract

Pyogenic granuloma (PG) is an acquired benign vascular tumor of unknown etiology. In the present case report, PG was detected in a 49-year-old Chinese male patient with chronic plaque psoriasis. The psoriasis lesions on the finger where the granuloma had developed had been scratched excessively, as declared by the patient. No retinoid therapeutic agents were used during treatment. The patient responded poorly to cryotherapy and surgical curettage. However, following one session of 5‑aminolevulinic acid photodynamic therapy (ALA‑PDT), signs of improvement were demonstrated 1 week after the treatment, and 1 month following treatment, there were no signs of reoccurrence. Although a report demonstrating treatment success in one patient may be inadequate to estimate the true efficiency of ALA‑PDT, dermatologists may consider ALA-PDT as an alternative therapy for stubborn PG.

View Figures

View References

1	Piraccini BM, Venturi M and Patrizi A: Periungual pyogenic granulomas due to topical tazarotene for nail psoriasis. G Ital Dermatol Venereol. 149:363–366. 2014.PubMed/NCBI
2	Piraccini BM, Bellavista S, Misciali C, Tosti A, de Berker D and Richert B: Periungual and subungual pyogenic granuloma. Br J Dermatol. 163:941–953. 2010. View Article : Google Scholar : PubMed/NCBI
3	Lowes MA, Bowcock AM and Krueger JG: Pathogenesis and therapy of psoriasis. Nature. 445:866–873. 2007. View Article : Google Scholar : PubMed/NCBI
4	Millsop JW, Trinh N, Winterfield L, Berrios R, Hutchens KA and Tung R: Resolution of recalcitrant pyogenic granuloma with laser, corticosteroid, and timolol therapy. Dermatol Online J. 20:2014.PubMed/NCBI
5	Campbell JP, Grekin RC, Ellis CN, Matsuda-John SS, Swanson NA and Voorhees JJ: Retinoid therapy is associated with excess granulation tissue responses. J Am Acad Dermatol. 9:708–713. 1983. View Article : Google Scholar : PubMed/NCBI
6	Badri T, Hawilo AM, Benmously R, Fenniche S and Mokhtar I: Acitretin-induced pyogenic granuloma. Acta Dermatovenerol Alp Pannonica Adriat. 20:217–218. 2011.PubMed/NCBI
7	Das RP, Jain AK and Ramesh V: Current concepts in the pathogenesis of psoriasis. Indian J Dermatol. 54:7–12. 2009. View Article : Google Scholar : PubMed/NCBI
8	Hugh J, Van Voorhees AS, Nijhawan RI, et al: From the Medical Board of the National Psoriasis Foundation: The risk of cardiovascular disease in individuals with psoriasis and the potential impact of current therapies. J Am Acad Dermatol. 70:168–177. 2014. View Article : Google Scholar : PubMed/NCBI
9	Flisiak I, Zaniewski P, Rogalska-Taranta M and Chodynicka B: Effect of psoriasis therapy on VEGF and its soluble receptors serum concentrations. J Eur Acad Dermatol Venereol. 26:302–307. 2012. View Article : Google Scholar : PubMed/NCBI
10	Li W, Man XY, Chen JQ, Zhou J, Cai SQ and Zheng M: Targeting VEGF/VEGFR in the treatment of psoriasis. Discov Med. 18:97–104. 2014.PubMed/NCBI
11	Patruno C, Balato N, Cirillo T, Napolitano M and Ayala F: Periungual and subungual pyogenic granuloma following anti-TNF-α therapy: Is it the first case? Dermatol Ther. 26:493–495. 2013. View Article : Google Scholar : PubMed/NCBI
12	Richert B: Frictional pyogenic granuloma of the nail bed. Dermatology. 202:80–81. 2001. View Article : Google Scholar : PubMed/NCBI
13	Lee J, Sinno H, Tahiri Y and Gilardino MS: Treatment options for cutaneous pyogenic granulomas: A review. J Plast Reconstr Aesthet Surg. 64:1216–1220. 2011. View Article : Google Scholar : PubMed/NCBI
14	Wan MT and Lin JY: Current evidence and applications of photodynamic therapy in dermatology. Clin Cosmet Investig Dermatol. 7:145–163. 2014.PubMed/NCBI
15	Li W, Yamada I, Masumoto K, Ueda Y and Hashimoto K: Photodynamic therapy with intradermal administration of 5-aminolevulinic acid for port-wine stains. J Dermatolog Treat. 21:232–239. 2010.PubMed/NCBI
16	Park MY and Kim YC: Classic Kaposi sarcoma treated with intralesional 5-aminolevulinic acid injection photodynamic therapy. Arch Dermatol. 145:1200–1202. 2009. View Article : Google Scholar : PubMed/NCBI
17	Lee DJ, Kim EH, Jang YH and Kim YC: Photodynamic therapy with 5-aminolevulinic acid intralesional injection for pyogenic granuloma. Arch Dermatol. 148:126–128. 2012. View Article : Google Scholar : PubMed/NCBI
18	Rodriguez L, de Bruijn HS, Di Venosa G, Mamone L, Robinson J, Juarranz A, Batlle A and Casas A: Porphyrin synthesis from aminolevulinic acid esters in endothelial cells and its role in photodynamic therapy. J Photochem Photobiol B. 96:249–254. 2009. View Article : Google Scholar : PubMed/NCBI
19	Chang CJ, Sun CH, Liaw LH, Berns MW and Nelson JS: In vitro and in vivo photosensitizing capabilities of 5-ALA versus photofrin in vascular endothelial cells. Lasers Surg Med. 24:178–186. 1999. View Article : Google Scholar : PubMed/NCBI
20	Xie Y, Wei ZB, Zhang Z, Wen W and Huang GW: Effect of 5-ALA-PDT on VEGF and PCNA expression in human NPC-bearing nude mice. Oncol Rep. 22:1365–1371. 2009.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pyogenic granuloma in a patient with psoriasis successfully treated by 5-aminolevulinic acid photodynamic therapy: A case report

This article is mentioned in:

Abstract

Figure 1

Related Articles