Effect of rikkunshi-to treatment on chemotherapy-induced appetite loss in patients with lung cancer: A prospective study

Oteki,Takako; Ishikawa,Asuka; Sasaki,Yoshie; Ohara,Gen; Kagohashi,Katsunori; Kurishima,Koichi; Satoh,Hiroaki

doi:10.3892/etm.2015.2903

January-2016 Volume 11 Issue 1

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January-2016 Volume 11 Issue 1

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Article

Effect of rikkunshi-to treatment on chemotherapy-induced appetite loss in patients with lung cancer: A prospective study

Authors:
- Takako Oteki
- Asuka Ishikawa
- Yoshie Sasaki
- Gen Ohara
- Katsunori Kagohashi
- Koichi Kurishima
- Hiroaki Satoh
View Affiliations / Copyright

Affiliations: Division of Pharmacy, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan, Division of Nursing, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan, Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan
Pages: 243-246
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Published online on: November 27, 2015

https://doi.org/10.3892/etm.2015.2903
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Abstract

The aim of the present study was to investigate the effect of rikkunshi-to, a Japanese herbal medicine, on post-chemotherapeutic appetite loss. Patients with unresectable lung cancer, who were treated with carboplatin (CBDCA)‑containing, cisplatin (CDDP)‑containing or non‑platinum chemotherapy between 2011 and 2014, were recruited for the prospective study. For each course of chemotherapy, the patients were randomized into two groups, with or without a rikkunshi‑to prescription. In patients treated with CBDCA‑containing chemotherapy, food intake at day 7 following the initiation of chemotherapy in the rikkunshi‑to treatment group was significantly higher compared with the group not treated with rikkunshi‑to (P=0.0078). However, a significant improvement in food intake with rikkunshi‑to treatment was not observed in the CDDP‑containing and non‑platinum chemotherapy groups. An improved assessment of the incidence rate of chemotherapy‑induced appetite loss is essential for achieving adequate control. The results of the present study indicated the possibility of the clinical application of rikkunshi-to for improving post-chemotherapeutic appetite loss.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of rikkunshi-to treatment on chemotherapy-induced appetite loss in patients with lung cancer: A prospective study

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