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Article

Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells

  • Authors:
    • Haiyang Zhang
    • Xia Zhong
    • Xiao Zhang
    • Deya Shang
    • Yi Zhou
    • Chunqing Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Shandong Center for Disease Control and Prevention, Jinan, Shandong 250014, P.R. China, Division of Hepatogastroenterology, Department of Internal Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
  • Pages: 669-673
    |
    Published online on: December 4, 2015
       https://doi.org/10.3892/etm.2015.2912
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Abstract

Gastric cancer is the second leading cause of cancer‑associated mortality and is a frequently occurring cancer worldwide. Multiple drug resistance of gastric cancer cells leads to the poor prognosis. In addition, overexpression of anti-apoptotic protein B-cell lymphoma (Bcl)-2 have been demonstrated in various cancer cells and is closely associated with drug resistance and poor prognosis. Naringenin is a flavonoid that has antimutagenic and anticarcinogenic activities in numerous cancer types. In the present study, naringenin and a Bcl‑2 inhibitor, ABT‑737, were used to investigate their combinative anticancer effect in the SGC7901 gastric cancer cell line. The results revealed that naringenin and ABT‑737 were able to inhibit SGC7901 cell growth and colony formation, alone or in combination. Furthermore, the combination of these drugs was found to further increase the cleavage of caspase‑3 and poly ADP‑ribose polymerase. Naringenin and ABT‑737 also decreased Akt activation and increased p53 expression, suggesting the involvement of these pathways in the inhibition of gastric cell growth.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Zhong X, Zhang X, Shang D, Zhou Y and Zhang C: Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells. Exp Ther Med 11: 669-673, 2016.
APA
Zhang, H., Zhong, X., Zhang, X., Shang, D., Zhou, Y., & Zhang, C. (2016). Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells. Experimental and Therapeutic Medicine, 11, 669-673. https://doi.org/10.3892/etm.2015.2912
MLA
Zhang, H., Zhong, X., Zhang, X., Shang, D., Zhou, Y., Zhang, C."Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells". Experimental and Therapeutic Medicine 11.2 (2016): 669-673.
Chicago
Zhang, H., Zhong, X., Zhang, X., Shang, D., Zhou, Y., Zhang, C."Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells". Experimental and Therapeutic Medicine 11, no. 2 (2016): 669-673. https://doi.org/10.3892/etm.2015.2912
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Zhong X, Zhang X, Shang D, Zhou Y and Zhang C: Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells. Exp Ther Med 11: 669-673, 2016.
APA
Zhang, H., Zhong, X., Zhang, X., Shang, D., Zhou, Y., & Zhang, C. (2016). Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells. Experimental and Therapeutic Medicine, 11, 669-673. https://doi.org/10.3892/etm.2015.2912
MLA
Zhang, H., Zhong, X., Zhang, X., Shang, D., Zhou, Y., Zhang, C."Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells". Experimental and Therapeutic Medicine 11.2 (2016): 669-673.
Chicago
Zhang, H., Zhong, X., Zhang, X., Shang, D., Zhou, Y., Zhang, C."Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells". Experimental and Therapeutic Medicine 11, no. 2 (2016): 669-673. https://doi.org/10.3892/etm.2015.2912
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