Proton pump inhibitor‑induced exfoliative dermatitis: A case report

Qiu,Zhihong; Liu,Hongtao; He,Lien; Ma,Yinling; Song,Haojing; Bai,Wanjun; Yu,Meiling

doi:10.3892/etm.2015.2926

February-2016 Volume 11 Issue 2

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February-2016 Volume 11 Issue 2

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Case Report

Proton pump inhibitor‑induced exfoliative dermatitis: A case report

Authors:
- Zhihong Qiu
- Hongtao Liu
- Lien He
- Yinling Ma
- Haojing Song
- Wanjun Bai
- Meiling Yu
View Affiliations / Copyright

Affiliations: Department of Pharmacy, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China, Department of Pharmacy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China
Pages: 543-546
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Published online on: December 8, 2015

https://doi.org/10.3892/etm.2015.2926
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Abstract

A 74‑year‑old female patient was admitted to hospital following a road accident with pains in the chest, abdomen, waist, back, nose, left wrist and lower limbs. After 1 week, the patient presented with gastrointestinal bleeding, and thus was treated with protein pump inhibitors (PPIs), including lansoprazole, esomeprazole and omeprazole enteric‑coated tablets, in order to inhibit acid secretion and attenuate bleeding. However, the patient developed skin rashes on the chest and right lower limb and foot 28 days following treatment initiation. The skin rashes spread and ulcerated after 3 days, and were associated with tracheal mucosal injury and hemoptysis. Subsequently, treatment of the patient with PPIs was terminated, after which the tracheal hemoptysis and skin rashes markedly improved. In addition, no new skin rashes appeared following termination of the PPI treatment. In the present case, long‑term treatment of an elderly patient with PPIs may have induced exfoliative dermatitis, due to hepatic ischemia, hypoxia and acute renal failure, which may have decreased the metabolism of PPIs, resulting in the accumulation of PPI metabolites.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Proton pump inhibitor‑induced exfoliative dermatitis: A case report

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Abstract

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