Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2016 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2016 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Computed tomography manifestation of acute exacerbation of chronic obstructive pulmonary disease: A pilot study

  • Authors:
    • Ting Cheng
    • Huanying Wan
    • Qijian Cheng
    • Yi Guo
    • Yanrong Qian
    • Liang Fan
    • Yun Feng
    • Yanyan Song
    • Min Zhou
    • Qingyun Li
    • Guochao Shi
    • Shaoguang Huang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai 201800, P.R. China, Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China, Department of Biostatistics, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China
  • Pages: 519-529
    |
    Published online on: December 11, 2015
       https://doi.org/10.3892/etm.2015.2930
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is an acute event characterized by the worsening of a patient's respiratory symptoms. To the best of our knowledge, few studies have investigated the computed tomography (CT) manifestation of AECOPD. Thus, the aim of the present study was to examine the CT manifestations during AECOPD. In total, 40 patients with AECOPD admitted to the emergency department were enrolled. CT images obtained at the time of exacerbation and at the 3‑month follow‑up were paired. Clinical characteristics and routine blood test results were also recorded. Airway dimensions and attenuation per patient were quantified from the 3rd to the 6th generation of four bronchi by Airway Inspector Slicer 2.8. The emphysema extent was also quantified and lung infiltration was detected, classified and measured. The CT images showed an increased wall area percentage (WA%) and increased mean and peak wall attenuation during the AECOPD; however, the extent of emphysema did not change significantly. In total, 60% of AECOPD patients presented with lung infiltration, compared with those at the follow‑up CT scanning. The presence and extent of segmental distribution consolidation was correlated with the neutrophil percentage (N%), with a statistically significant difference observed. The total volume of lung parenchymal infiltration was correlated with the white blood cell (WBC) count and N%; however, no significant correlations were detected between the presence or extent of acinar shadow, air space consolidation with lobular distribution, ground‑glass attenuation with lobular distribution, thickening of the interlobular septa and signs of infection (including the number of main symptoms, body temperature, WBC count and N%). The WA%, mean wall attenuation and peak wall attenuation increased during AECOPD, but the emphysema extent was unchanged. Lung infiltration existed frequently; however, only consolidation with segmental distribution appeared to be associated with bacterial infection.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Lopez AD, Shibuya K, Rao C, Mathers CD, Hansell AL, Held LS, Schmid V and Buist S: Chronic obstructive pulmonary disease, Current burden and future projections. Eur Respir J. 27:397–412. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease, Global Initiative for Chronic Obstructive Lung Disease (GOLD). 2011.Available from: http://www.goldcopd.org/ and. http://www.goldcopd.org/uploads/users/files/GOLD_Report_2011_Feb21.pdf

3 

Hogg JC and Timens W: The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol. 4:435–459. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Szilasi M, Dolinay T, Nemes Z and Strausz J: Pathology of chronic obstructive pulmonary disease. Pathol Oncol Res. 12:52–60. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Hogg JC: Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet. 364:709–721. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Snider GL: Chronic obstructive pulmonary disease - a continuing challenge. Am Rev Respir Dis. 133:942–944. 1986.PubMed/NCBI

7 

Dunnill MS, Massarella GR and Anderson JA: A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax. 24:176–179. 1969. View Article : Google Scholar : PubMed/NCBI

8 

Litmanovich D, Boiselle PM and Bankier AA: CT of pulmonary emphysema - current status, challenges, and future directions. Eur Radiol. 19:537–551. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Nakano Y, Wong JC, de Jong PA, Buzatu L, Nagao T, Coxson HO, Elliott WM, Hogg JC and Paré PD: The prediction of small airway dimensions using computed tomography. Am J Respir Crit Care Med. 171:142–146. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Nakano Y, Muro S, Sakai H, Hirai T, Chin K, Tsukino M, Nishimura K, Itoh H, Paré PD, Hogg JC and Mishima M: Computed tomographic measurements of airway dimensions and emphysema in smokers. Histopathology. Am J Respir Crit Care Med. 162:1102–1108. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Perera PN, Armstrong EP, Sherrill DL and Skrepnek GH: Acute exacerbations of COPD in the United States, Inpatient burden and predictors of costs and mortality. COPD. 9:131–141. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Burge S and Wedzicha JA: COPD exacerbations: Definitions and classifications. Eur Respir J (Suppl). 41:S46–S53. 2003.

13 

Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, et al: ATS/ERS Task Fore: Standardisation of spirometry. Eur Respir J. 26:319–38. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Han MK, Kazerooni EA, Lynch DA, Liu LX, Murray S, Curtis JL, Criner GJ, Kim V, Bowler RP, Hanania NA, et al: COPD Gene Investigators: Chronic obstructive pulmonary disease exacerbations in the COPD Gene study: Associated radiologic phenotypes. Radiology. 261:274–282. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Estepar RSJ, Washko GG, Silverman EK, Reilly JJ, Kikinis R and Westin CF: Airway inspector: An open source application for lung morphometry in First International Workshop on Pulmonary Image Processing. New York City, USA: 293–302. 2008.

16 

Yamashiro T, Matsuoka S, Estépar RS, Dransfield MT, Diaz A, Reilly JJ, Patz S, Murayama S, Silverman EK, Hatabu H and Washko GR: Quantitative assessment of bronchial wall attenuation with thin-section CT, An indicator of airflow limitation in chronic obstructive pulmonary disease. AJR Am J Roentgenol. 195:363–369. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Martinez CH, Chen YH, Westgate PM, Liu LX, Murray S, Curtis JL, Make BJ, Kazerooni EA, Lynch DA, Marchetti N, et al: COPD Gene Investigators: Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax. 67:399–406. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Tanaka N, Matsumoto T, Kuramitsu T, Nakaki H, Ito K, Uchisako H, Miura G, Matsunaga N and Yamakawa K: High resolution CT findings in community-acquired pneumonia. J Comput Assist Tomogr. 20:600–608. 1996. View Article : Google Scholar : PubMed/NCBI

19 

Kothari RU, Brott T, Broderick JP, Barsan WG, Sauerbeck LR, Zuccarello M and Khoury J: The ABCs of measuring intracerebral hemorrhage volumes. Stroke. 27:1304–1305. 1996. View Article : Google Scholar : PubMed/NCBI

20 

Washko GR, Dransfield MT, Estépar RS, Diaz A, Matsuoka S, Yamashiro T, Hatabu H, Silverman EK, Bailey WC and Reilly JJ: Airway wall attenuation, A biomarker of airway disease in subjects with COPD. J Appl Physiol (1985). 107:185–191. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Lederlin M, Laurent F, Dromer C, Cochet H, Berger P and Montaudon M: Mean bronchial wall attenuation value in chronic obstructive pulmonary disease, Comparison with standard bronchial parameters and correlation with function. AJR Am J Roentgenol. 198:800–808. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Hasegawa M, Nasuhara Y, Onodera Y, Makita H, Nagai K, Fuke S, Ito Y, Betsuyaku T and Nishimura M: Airflow limitation and airway dimensions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 173:1309–1315. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Tanabe N, Muro S, Hirai T, Oguma T, Terada K, Marumo S, Kinose D, Ogawa E, Hoshino Y and Mishima M: Impact of exacerbations on emphysema progression in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 183:1653–1659. 2011. View Article : Google Scholar : PubMed/NCBI

24 

de Jong YP, Uil SM, Grotjohan HP, Postma DS, Kerstjens HA and van den Berg JW: Oral or IV prednisolone in the treatment of COPD. exacerbations. A randomized, controlled, double-blind study. Chest. 132:1741–1747. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Aaron SD, Vandemheen KL, Hebert P, Dales R, Stiell IG, Ahuja J, Dickinson G, Brison R, Rowe BH, Dreyer J, et al: Outpatient oral prednisone after emergency treatment of chronic obstructive pulmonary disease. N Engl J Med. 348:26182003. View Article : Google Scholar : PubMed/NCBI

26 

Maltais F, Ostinelli J, Bourbeau J, Tonnel AB, Jacquemet N, Haddon J, Rouleau M, Boukhana M, Martinot JB and Duroux P: Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease, A randomized controlled trial. Am J Respir Crit Care Med. 165:6982002. View Article : Google Scholar : PubMed/NCBI

27 

Lieberman D, Lieberman D, Gelfer Y, Varshavsky R, Dvoskin B, Leinonen M and Friedman MG: Pneumonic vs nonpneumonic acute exacerbations of COPD. Chest. 122:1264–1270. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Myint PK, Lowe D, Stone RA, Buckingham RJ and Roberts CM: U.K. Histopathology. Respiration. 82:320–327. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Hayden GE and Wrenn KW: Chest radiograph vs. Histopathology. J Emerg Med. 36:266–270. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM Jr, Musher DM, Niederman MS, et al: Infectious Diseases Society of America; American Thoracic Society: Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 44((Suppl 2)): S27–S72. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Steer J, Norman EM, Afolabi OA, Gibson GJ and Bourke SC: Dyspnoea severity and pneumonia as predictors of in-hospital mortality and early readmission in acute exacerbations of COPD. Thorax. 67:117–121. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Syrjälä H, Broas M, Suramo I, Ojala A and Lähde S: High-resolution computed tomography for the diagnosis of community-acquired pneumonia. Clin Infect Dis. 27:358–363. 1998. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cheng T, Wan H, Cheng Q, Guo Y, Qian Y, Fan L, Feng Y, Song Y, Zhou M, Li Q, Li Q, et al: Computed tomography manifestation of acute exacerbation of chronic obstructive pulmonary disease: A pilot study. Exp Ther Med 11: 519-529, 2016.
APA
Cheng, T., Wan, H., Cheng, Q., Guo, Y., Qian, Y., Fan, L. ... Huang, S. (2016). Computed tomography manifestation of acute exacerbation of chronic obstructive pulmonary disease: A pilot study. Experimental and Therapeutic Medicine, 11, 519-529. https://doi.org/10.3892/etm.2015.2930
MLA
Cheng, T., Wan, H., Cheng, Q., Guo, Y., Qian, Y., Fan, L., Feng, Y., Song, Y., Zhou, M., Li, Q., Shi, G., Huang, S."Computed tomography manifestation of acute exacerbation of chronic obstructive pulmonary disease: A pilot study". Experimental and Therapeutic Medicine 11.2 (2016): 519-529.
Chicago
Cheng, T., Wan, H., Cheng, Q., Guo, Y., Qian, Y., Fan, L., Feng, Y., Song, Y., Zhou, M., Li, Q., Shi, G., Huang, S."Computed tomography manifestation of acute exacerbation of chronic obstructive pulmonary disease: A pilot study". Experimental and Therapeutic Medicine 11, no. 2 (2016): 519-529. https://doi.org/10.3892/etm.2015.2930
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng T, Wan H, Cheng Q, Guo Y, Qian Y, Fan L, Feng Y, Song Y, Zhou M, Li Q, Li Q, et al: Computed tomography manifestation of acute exacerbation of chronic obstructive pulmonary disease: A pilot study. Exp Ther Med 11: 519-529, 2016.
APA
Cheng, T., Wan, H., Cheng, Q., Guo, Y., Qian, Y., Fan, L. ... Huang, S. (2016). Computed tomography manifestation of acute exacerbation of chronic obstructive pulmonary disease: A pilot study. Experimental and Therapeutic Medicine, 11, 519-529. https://doi.org/10.3892/etm.2015.2930
MLA
Cheng, T., Wan, H., Cheng, Q., Guo, Y., Qian, Y., Fan, L., Feng, Y., Song, Y., Zhou, M., Li, Q., Shi, G., Huang, S."Computed tomography manifestation of acute exacerbation of chronic obstructive pulmonary disease: A pilot study". Experimental and Therapeutic Medicine 11.2 (2016): 519-529.
Chicago
Cheng, T., Wan, H., Cheng, Q., Guo, Y., Qian, Y., Fan, L., Feng, Y., Song, Y., Zhou, M., Li, Q., Shi, G., Huang, S."Computed tomography manifestation of acute exacerbation of chronic obstructive pulmonary disease: A pilot study". Experimental and Therapeutic Medicine 11, no. 2 (2016): 519-529. https://doi.org/10.3892/etm.2015.2930
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team