Radiation‑induced anaplastic ependymoma mimicking a skull base meningioma: A case report

Spallone,Aldo; Marchione,Pasquale; Di Capua,Mario; Belvisi,Daniele

doi:10.3892/etm.2015.2945

February-2016 Volume 11 Issue 2

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February-2016 Volume 11 Issue 2

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Case Report

Radiation‑induced anaplastic ependymoma mimicking a skull base meningioma: A case report

Authors:
- Aldo Spallone
- Pasquale Marchione
- Mario Di Capua
- Daniele Belvisi
View Affiliations / Copyright

Affiliations: Section of Neurosurgery, Department of Clinical Neurosciences, Neurological Centre of Latium, Rome I‑00178, Italy, Clinical Neurophysiology Unit, Neuromed Institute IRCCS, Pozzilli I‑86077, Italy
Pages: 455-457
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Published online on: December 16, 2015

https://doi.org/10.3892/etm.2015.2945
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Abstract

The present study describes the case of a 63‑year‑old woman presenting with headache, dizziness and vomiting due to a an ovoid mass in the left pre‑bulbar cistern, apparently arising from the lower clivus and the foramen magnum. The clinical history revealed the subtotal removal of a right cerebellar low‑grade glioma 15 years previously and subsequent conventional 60‑Gy radiotherapy. Notably, following gross total resection, histopathological examination showed microscopic features that resulted in a diagnosis of anaplastic ependymoma. The patient underwent surgery to remove the mass and post‑operative chemotherapy with temozolomide. A progressive improvement of neurological signs and symptoms was observed during the postoperative course. At the 6‑month follow‑up, the patient was free from clinical and radiological recurrence. The unusual features of this rare secondary brain tumor were the extrassial location in the posterior fossa, the unusual age‑associated location of the histological subtype and the fact that it closely mimicked a skull‑base meningioma.

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1	Ecemis GC, Atmaca A and Meydan D: Radiation-associated secondary brain tumors after conventional radiotherapy and radiosurgery. Expert Rev Neurother. 13:557–565. 2013. View Article : Google Scholar : PubMed/NCBI
2	Cahan WG and Woodard HQ: Sarcoma arising in irradiated bone; report of 11 cases. Cancer. 1:3–29. 1948. View Article : Google Scholar : PubMed/NCBI
3	Waga S and Handa H: Radiation-induced meningioma: With review of literature. Surg Neurol. 5:215–229. 1976.PubMed/NCBI
4	Schwartz TH, Kim S, Glick RS, Bagiella E, Balmaceda C, Fetell MR, Stein BM, Sisti MB and Bruce JN: Supratentorial ependymomas in adult patients. Neurosurgery. 44:721–731. 1999. View Article : Google Scholar : PubMed/NCBI
5	Mork SJ and Loken AC: A follow-up study of 101 cases. Cancer. 40:907–915. 1977. View Article : Google Scholar : PubMed/NCBI
6	Coulon RA and Till K: Intracranial ependymomas in children: A review of 43 cases. Childs Brain. 3:154–164. 1977.PubMed/NCBI
7	Khoo HM, Kishima H, Kinoshita M, Goto Y, Kagawa N, Hashimoto N, Maruno M and Yoshimine T: Radiation-induced anaplastic ependymoma with a remarkable clinical response to temozolomide, A case report. Br J Neurosurg. 27:259–261. 2013. View Article : Google Scholar : PubMed/NCBI
8	Salvati M, Frati A, Russo N, Caroli E, Polli FM, Minniti G and Delfini R: Radiation-induced gliomas, Report of 10 cases and review of the literature. Surg Neurol. 60:60–67. 2003. View Article : Google Scholar : PubMed/NCBI
9	Spallone A, Gagliardi FM and Vagnozzi R: Intracranil meningiomas related to external cranial radiation. Surg Neurol. 12:153–159. 1979.PubMed/NCBI
10	Umansky F, Shoshan Y, Rosenthal G, Fraifeld S and Spektor S: Radiation-induced meningioma. Neurosurg Focus. 24:E72008. View Article : Google Scholar : PubMed/NCBI
11	Spallone A, Izzo C and Orlandi A: Post traumatic glioma, Report of a case. Case Rep Oncol. 7:403–409. 2013.
12	Spallone A, Neroni M and Giuffrè R: Multiple skull base meningioma Case report. Surg Neurol. 51:274–280. 1999. View Article : Google Scholar : PubMed/NCBI
13	Paulino AC, Mai WY, Chintagumpala M, Taher A and Teh BS: Radiation-induced malignant gliomas, Is there a role for reirradiation? Int J Radiat Oncol Biol Phys. 71:1381–1387. 2008. View Article : Google Scholar : PubMed/NCBI
14	Alexander MJ, DeSalles AA and Tomiyasu U: Multiple radiation-induced intracranial lesions after treatment for pituitary adenoma. Histopathology. J Neurosurg. 88:111–115. 1998. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Radiation‑induced anaplastic ependymoma mimicking a skull base meningioma: A case report

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