Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2016 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2016 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Hydrogen sulfide improves neural function in rats following cardiopulmonary resuscitation

  • Authors:
    • Ji‑Yan Lin
    • Min‑Wei Zhang
    • Jin‑Gao Wang
    • Hui Li
    • Hong‑Yan Wei
    • Rong Liu
    • Gang Dai
    • Xiao‑Xing Liao
  • View Affiliations / Copyright

    Affiliations: Department of Emergency and Critical Care Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China, Department of Emergency, The First Affiliated Hospital of Sun‑Yat Sen University, Guangzhou, Guangdong 510080, P.R. China, Key Laboratory on Assisted Circulation, Ministry of Health, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 577-587
    |
    Published online on: December 16, 2015
       https://doi.org/10.3892/etm.2015.2950
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The alleviation of brain injury is a key issue following cardiopulmonary resuscitation (CPR). Hydrogen sulfide (H2S) is hypothesized to be involved in the pathophysiological process of ischemia‑reperfusion injury, and exerts a protective effect on neurons. The aim of the present study was to investigate the effects of H2S on neural functions following cardiac arrest (CA) in rats. A total of 60 rats were allocated at random into three groups. CA was induced to establish the model and CPR was performed after 6 min. Subsequently, sodium hydrosulfide (NaHS), hydroxylamine or saline was administered to the rats. Serum levels of H2S, neuron‑specific enolase (NSE) and S100β were determined following CPR. In addition, neurological deficit scoring (NDS), the beam walking test (BWT), prehensile traction test and Morris water maze experiment were conducted. Neuronal apoptosis rates were detected in the hippocampal region following sacrifice. After CPR, as the H2S levels increased or decreased, the serum NSE and S100β concentrations decreased or increased, respectively (P<0.0w. The NDS results of the NaHS group were improved compared with those of the hydroxylamine group at 24 h after CPR (P<0.05). In the Morris water maze experiment, BWT and prehensile traction test the animals in the NaHS group performed best and rats in the hydroxylamine group performed worst. At day 7, the apoptotic index and the expression of caspase‑3 were reduced in the hippocampal CA1 region, while the expression of Bcl‑2 increased in the NaHS group; and results of the hydroxylamine group were in contrast. Therefore, the results of the present study indicate that H2S is able to improve neural function in rats following CPR.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Lemiale V, Dumas F, Mongardon N, Giovanetti O, Charpentier J, Chiche JD, Carli P, Mira JP, Nolan J and Cariou A: Intensive care unit mortality after cardiac arrest, The relative contribution of shock and brain injury in a large cohort. Intensive Care Med. 39:1972–1980. 2013. View Article : Google Scholar : PubMed/NCBI

2 

McCook O, Radermacher P, Volani C, Asfar P, Ignatius A, Kemmler J, Möller P, Szabó C, Whiteman M, Wood ME, et al: H2S during circulatory shock: Some unresolved questions. Nitric Oxide. 41:48–61. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Luo Y, Yang X, Zhao S, Wei C, Yin Y, Liu T, Jiang S, Xie J, Wan X, Mao M, et al: Hydrogen sulfide prevents OGD/R-induced apoptosis via improving mitochondrial dysfunction and suppressing an ROS-mediated caspase-3 pathway in cortical neurons. Neurochem Int. 63:826–831. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Wang Y, Jia J, Ao G, Hu L, Liu H, Xiao Y, Du H, Alkayed NJ, Liu CF and Cheng J: Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia. J Neurochem. 129:827–838. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Zhang M, Shan H, Chang P, Wang T, Dong W, Chen X and Tao L: Hydrogen sulfide offers neuroprotection on traumatic brain injury in parallel with reduced apoptosis and autophagy in mice. PLoS One. 9:e872412014. View Article : Google Scholar : PubMed/NCBI

6 

Jiang X, Huang Y, Lin W, Gao D, Fei Z, Chen X and Tao L: Protective effects of hydrogen sulfide in a rat model of traumatic brain injury via activation of mitochondrial adenosine triphosphate-sensitive potassium channels and reduction of oxidative stress. J Surg Res. 184:e27–e35. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Zhang M, Shan H, Wang T, Liu W, Wang Y, Wang L, Zhang L, Chang P, Dong W, Chen X, et al: Dynamic change of hydrogen sulfide after traumatic brain injury and its effect in mice. Neurochem Res. 38:714–725. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Han Y, Qin J, Bu DF, Chang XZ, Yang ZX and Du JB: Gamma-aminobutyric acid B receptor regulates the expression of hydrogen sulfide/cystathionine-beta-synthase system in recurrent febrile seizures. Zhongguo Dang Dai Er Ke Za Zhi. 8:141–143. 2006.(In Chinese). PubMed/NCBI

9 

Han Y, Qin J, Chang X, Yang Z, Bu D and Du J: Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats. Neurosci Res. 53:216–219. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Markova J, Hudecova S, Soltysova A, Sirova M, Csaderova L, Lencesova L, Ondrias K and Krizanova O: Sodium/calcium exchanger is upregulated by sulfide signaling, forms complex with the β1 and β3 but not β2 adrenergic receptors, and induces apoptosis. Pflugers Arch. 466:1329–1342. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Kimura Y and Kimura H: Hydrogen sulfide protects neurons from oxidative stress. FASEB J. 18:1165–1167. 2004.PubMed/NCBI

12 

Minamishima S, Bougaki M, Sips PY, Yu JD, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD and Ichinose F: Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice. Circulation. 120:888–896. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Kida K, Minamishima S, Wang H, Ren J, Yigitkanli K, Nozari A, Mandeville JB, Liu PK, Liu CH and Ichinose F: Sodium sulfide prevents water diffusion abnormality in the brain and improves long term outcome after cardiac arrest in mice. Resuscitation. 83:1292–1297. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Derwall M, Westerkamp M, Löwer C, Deike-Glindemann J, Schnorrenberger NK, Coburn M, Nolte KW, Gaisa N, Weis J, Siepmann K, et al: Hydrogen sulfide does not increase resuscitability in a porcine model of prolonged cardiac arrest. Shock. 34:190–195. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Knapp J, Heinzmann A, Schneider A, Padosch SA, Böttiger BW, Teschendorf P and Popp E: Hypothermia and neuroprotection by sulfide after cardiac arrest and cardiopulmonary resuscitation. Resuscitation. 82:1076–1080. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Qu K, Lee SW, Bian JS, Low CM and Wong PT: Hydrogen sulfide, Neurochemistry and neurobiology. Neurochem Int. 52:155–165. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Lin JY, Liao XX, Li H, Wei HY, Liu R, Hu CL, Huang GQ, Dai G and Li X: Model of cardiac arrest in rats by transcutaneous electrical epicardium stimulation. Resuscitation. 81:1197–1204. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Idris AH, Becker LB, Ornato JP, Hedges JR, Bircher NG, Chandra NC, Cummins RO, Dick W, Ebmeyer U, Halperin HR, et al: Writing Group: Utstein-style guidelines for uniform reporting of laboratory CPR research. A statement for healthcare professionals from a task force of the American Heart Association, the American College of Emergency Physicians, the American College of Cardiology, the European Resuscitation Council, the Heart and Stroke Foundation of Canada, the Institute of Critical Care Medicine, the Safar Center for Resuscitation Research, and the Society for Academic Emergency Medicine. Circulation. 94:2324–2336. 1996. View Article : Google Scholar : PubMed/NCBI

19 

Neumar RW, Bircher NG, Sim KM, Xiao F, Zadach KS, Radovsky A, Katz L, Ebmeyer E and Safar P: Epinephrine and sodium bicarbonate during CPR following asphyxial cardiac arrest in rats. Resuscitation. 29:249–263. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Lin JY, Wei HY, Li H, Li X, Liu R, Hu CL, Huang GQ, Dai G and Liao XX: Change of hydrogen sulfide content in serum of rats after cardiopulmonary resuscitation. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 26:363–365. 2010.(In Chinese). PubMed/NCBI

21 

Morris R: Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods. 11:47–60. 1984. View Article : Google Scholar : PubMed/NCBI

22 

Vorhees CV and Williams MT: Morris water maze: Procedures for assessing spatial and related forms of learning and memory. Nat Protoc. 1:848–858. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Feeney DM, Gonzalez A and Law WA: Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury. Science. 217:855–857. 1982. View Article : Google Scholar : PubMed/NCBI

24 

Plaisier F, Bastide M, Ouk T, Pétrault O, Laprais M, Stolc S and Bordet R: Stobadine-induced hastening of sensorimotor recovery after focal ischemia/reperfusion is associated with cerebrovascular protection. Brain Res. 1208:240–249. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Møller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sørensen FB, Vesterby A, et al: Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS. 96:379–394. 1988. View Article : Google Scholar : PubMed/NCBI

26 

Li J, Han B, Ma X and Qi S: The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain ischemia-reperfusion in rats. Brain Res. 1356:11–23. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Fink EL, Berger RP, Clark RS, Watson RS, Angus DC, Richichi R, Panigrahy A, Callaway CW, Bell MJ and Kochanek PM: Serum biomarkers of brain injury to classify outcome after pediatric cardiac arrest. Crit Care Med. 42:664–674. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Sulaj M, Saniova B, Drobna E and Schudichova J: Serum neuron specific enolase and malondialdehyde in patients after out-of-hospital cardiac arrest. Cell Mol Neurobiol. 29:807–810. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Stammet P, Wagner DR, Gilson G and Devaux Y: Modeling serum level of s100β and bispectral index to predict outcome after cardiac arrest. J Am Coll Cardiol. 62:851–858. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Kleindienst A, Hesse F, Bullock MR and Buchfelder M: The neurotrophic protein S100B: Value as a marker of brain damage and possible therapeutic implications. Prog Brain Res. 161:317–325. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Drabek T, Stezoski J, Garman RH, Wu X, Tisherman SA, Stezoski SW, Fisk JA, Jenkins L and Kochanek PM: Emergency preservation and delayed resuscitation allows normal recovery after exsanguination cardiac arrest in rats, A feasibility trial. Crit Care Med. 35:532–537. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Popp E, Padosch SA, Vogel P, Schäbitz WR, Schwab S and Böttiger BW: Effects of intracerebroventricular application of brain-derived neurotrophic factor on cerebral recovery after cardiac arrest in rats. Crit Care Med. 32(Suppl): S359–S365. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Cronberg T, Lilja G, Rundgren M, Friberg H and Widner H: Long-term neurological outcome after cardiac arrest and therapeutic hypothermia. Resuscitation. 80:1119–1123. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Meert KL, Donaldson A, Nadkarni V, Tieves KS, Schleien CL, Brilli RJ, Clark RS, Shaffner DH, Levy F, Statler K, et al: Pediatric Emergency Care Applied Research Network: Multicenter cohort study of in-hospital pediatric cardiac arrest. Pediatr Crit Care Med. 10:544–553. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Schreckinger M, Geocadin RG, Savonenko A, Yamashita S, Melnikova T, Thakor NV and Hanley DF: Long-lasting cognitive injury in rats with apparent full gross neurological recovery after short-term cardiac arrest. Resuscitation. 75:105–113. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Garthe A and Kempermann G: An old test for new neurons: Refining the Morris water maze to study the functional relevance of adult hippocampal neurogenesis. Front Neurosci. 7:632013. View Article : Google Scholar : PubMed/NCBI

37 

Tahamtan M, Allahtavakoli M, Abbasnejad M, Roohbakhsh A, Taghipour Z, Taghavi M, Khodadadi H and Shamsizadeh A: Exercise preconditioning improves behavioral functions following transient cerebral ischemia induced by 4-vessel occlusion (4-VO) in rats. Arch Iran Med. 16:697–704. 2013.PubMed/NCBI

38 

Tamakoshi K, Ishida A, Takamatsu Y, Hamakawa M, Nakashima H, Shimada H and Ishida K: Motor skills training promotes motor functional recovery and induces synaptogenesis in the motor cortex and striatum after intracerebral hemorrhage in rats. Behav Brain Res. 260:34–43. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Zhang H, Sun R, Liu XY, Shi XM, Wang WF, Yu LG and Guo XL: A tetramethylpyrazine piperazine derivate CXC137 prevents cell injury in SH-SY5Y cells and improves memory dysfunction of rats with vascular Dementia. Neurochem Res. 39:276–286. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Thal SC, Mebmer K, Schmid-Elsaesser R and Zausinger S: Neurological impairment in rats after subarachnoid hemorrhage - a comparison of functional tests. J Neurol Sci. 268:150–159. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Szabó C: Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov. 6:917–935. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Zhang LM, Jiang CX and Liu DW: Hydrogen sulfide attenuates neuronal injury induced by vascular dementia via inhibiting apoptosis in rats. Neurochem Res. 34:1984–1992. 2009. View Article : Google Scholar : PubMed/NCBI

43 

DeMaster EG, Raij L, Archer SL and Weir EK: Hydroxylamine is a vasorelaxant and a possible intermediate in the oxidative conversion of L-arginine to nitric oxide. Biochem Biophys Res Commun. 163:527–533. 1989. View Article : Google Scholar : PubMed/NCBI

44 

Chao CC, Hu S, Molitor TW, Shaskan EG and Peterson PK: Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol. 149:2736–2741. 1992.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lin JY, Zhang MW, Wang JG, Li H, Wei HY, Liu R, Dai G and Liao XX: Hydrogen sulfide improves neural function in rats following cardiopulmonary resuscitation. Exp Ther Med 11: 577-587, 2016.
APA
Lin, J., Zhang, M., Wang, J., Li, H., Wei, H., Liu, R. ... Liao, X. (2016). Hydrogen sulfide improves neural function in rats following cardiopulmonary resuscitation. Experimental and Therapeutic Medicine, 11, 577-587. https://doi.org/10.3892/etm.2015.2950
MLA
Lin, J., Zhang, M., Wang, J., Li, H., Wei, H., Liu, R., Dai, G., Liao, X."Hydrogen sulfide improves neural function in rats following cardiopulmonary resuscitation". Experimental and Therapeutic Medicine 11.2 (2016): 577-587.
Chicago
Lin, J., Zhang, M., Wang, J., Li, H., Wei, H., Liu, R., Dai, G., Liao, X."Hydrogen sulfide improves neural function in rats following cardiopulmonary resuscitation". Experimental and Therapeutic Medicine 11, no. 2 (2016): 577-587. https://doi.org/10.3892/etm.2015.2950
Copy and paste a formatted citation
x
Spandidos Publications style
Lin JY, Zhang MW, Wang JG, Li H, Wei HY, Liu R, Dai G and Liao XX: Hydrogen sulfide improves neural function in rats following cardiopulmonary resuscitation. Exp Ther Med 11: 577-587, 2016.
APA
Lin, J., Zhang, M., Wang, J., Li, H., Wei, H., Liu, R. ... Liao, X. (2016). Hydrogen sulfide improves neural function in rats following cardiopulmonary resuscitation. Experimental and Therapeutic Medicine, 11, 577-587. https://doi.org/10.3892/etm.2015.2950
MLA
Lin, J., Zhang, M., Wang, J., Li, H., Wei, H., Liu, R., Dai, G., Liao, X."Hydrogen sulfide improves neural function in rats following cardiopulmonary resuscitation". Experimental and Therapeutic Medicine 11.2 (2016): 577-587.
Chicago
Lin, J., Zhang, M., Wang, J., Li, H., Wei, H., Liu, R., Dai, G., Liao, X."Hydrogen sulfide improves neural function in rats following cardiopulmonary resuscitation". Experimental and Therapeutic Medicine 11, no. 2 (2016): 577-587. https://doi.org/10.3892/etm.2015.2950
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team