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Efficacy and safety of testosterone replacement therapy in men with hypogonadism: A meta-analysis study of placebo-controlled trials

  • Authors:
    • Changcheng Guo
    • Wenyu Gu
    • Min Liu
    • Bo Peng
    • Xudong Yao
    • Bin Yang
    • Junhua Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 853-863
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    Published online on: December 23, 2015
       https://doi.org/10.3892/etm.2015.2957
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Abstract

The purpose of the present meta-analysis was to evaluate the efficacy and safety of testosterone replacement therapy in men with hypogonadism. A search was conducted for appropriate randomized controlled trials and the data from 16 trials were pooled. The intended primary outcome of the present study was to determine the efficacy and safety of testosterone replacement therapy. The current data demonstrated that scores for Aging Male Symptoms (AMS) were significantly reduced following testosterone replacement therapy, with a mean decrease in AMS score of 1.52 [95% confidence interval (CI), 0.72 to 2.32; P=0.0002]. Testosterone replacement therapy increased lean body mass [mean difference (MD), 1.22; 95% CI, 0.33 to 2.11; P=0.007], reduced fat mass in a non‑significantly manner (MD, ‑0.85; 95% CI, ‑1.74 to 0.04; P=0.06) and significantly reduced total cholesterol (MD, ‑0.16; 95% CI, ‑0.29 to ‑0.03; P=0.01). No significant differences were identified in body weight (MD, 0.09; 95% CI, ‑1.13 to 1.31; P=0.89), body mass index (MD, 0.10; 95% CI, ‑0.62 to 0.82; P=0.78) or bone mineral density (MD, ‑0.01; 95% CI, ‑0.03 to 0.02; P=0.60). Average prostate volume increased (MD, 1.58; 95% CI, 0.6 to 2.56; P=0.002) following testosterone replacement therapy, but the levels of prostate‑specific antigen (PSA) (MD, 0.10; 95% CI, ‑0.03 to 0.22; P=0.14) and the International Prostate Symptom Scores (MD, 0.01; 95% CI, ‑0.37 to 0.39; P=0.96) did not change. In conclusion, testosterone replacement therapy improves quality of life, increases lean body mass, significantly decreases total cholesterol, and is well‑tolerated and safe for men with hypogonadism who are exhibiting PSA levels of <4 ng/ml.
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1 

Cardarelli R, Singh M, Meyer J, Balyakina E, Perez O and King M: The association of free testosterone levels in men and lifestyle factors and chronic disease status: A North Texas Healthy Heart Study. J Prim Care Community Health. 5:173–179. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Ferreira SR: Cushing and Arquivos Brasileiros de Endocrinologia e Metabologia Award 2006. Arq Bras Endocrinol Metabol. 51:11812007.(In Portuguese). View Article : Google Scholar : PubMed/NCBI

3 

Cui Y, Zong H, Yan H and Zhang Y: The effect of testosterone replacement therapy on prostate cancer: A systematic review and meta-analysis. Prostate Cancer Prostatic Dis. 17:132–143. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Bassil N: Late-onset hypogonadism. Med Clin North Am. 95:507–523. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Donatucci C, Cui Z, Fang Y and Muram D: Long-term treatment patterns of testosterone replacement medications. J Sex Med. 11:2092–2099. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Behre HM, Tammela TL, Arver S, Tolrá JR, Bonifacio V, Lamche M, Kelly J, Hiemeyer F, Giltay EJ and Gooren LJ: European Testogel Study Team: A randomized, double-blind, placebo-controlled trial of testosterone gel on body composition and health-related quality-of-life in men with hypogonadal to low-normal levels of serum testosterone and symptoms of androgen deficiency over 6 months with 12 months open-label follow-up. Aging Male. 15:198–207. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Emmelot-Vonk MH, Verhaar HJ, Pour Nakhai HR, Aleman A, Lock TM, Bosch JL, Grobbee DE and van der Schouw YT: Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: A randomized controlled trial. JAMA. 299:39–52. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Amory JK, Watts NB, Easley KA, Sutton PR, Anawalt BD, Matsumoto AM, Bremner WJ and Tenover JL: Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone. J Clin Endocrinol Metab. 89:503–510. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Cavallini G, Caracciolo S, Vitali G, Modenini F and Biagiotti G: Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. Urology. 63:641–646. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Page ST, Amory JK, Bowman FD, Anawalt BD, Matsumoto AM, Bremner WJ and Tenover JL: Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab. 90:1502–1510. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Marks LS, Mazer NA, Mostaghel E, Hess DL, Dorey FJ, Epstein JI, Veltri RW, Makarov DV, Partin AW, Bostwick DG, et al: Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: A randomized controlled trial. JAMA. 296:2351–2361. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Vaughan C, Goldstein FC and Tenover JL: Exogenous testosterone alone or with finasteride does not improve measurements of cognition in healthy older men with low serum testosterone. J Androl. 28:875–882. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Aversa A, Bruzziches R, Francomano D, Rosano G, Isidori AM, Lenzi A and Spera G: Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: Results from a 24-month, randomized, double-blind, placebo-controlled study. J Sex Med. 7:3495–3503. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Aversa A, Bruzziches R, Francomano D, Spera G and Lenzi A: Efficacy and safety of two different testosterone undecanoate formulations in hypogonadal men with metabolic syndrome. J Endocrinol Invest. 33:776–783. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Idan A, Griffiths KA, Harwood DT, Seibel MJ, Turner L, Conway AJ and Handelsman DJ: Long-term effects of dihydrotestosterone treatment on prostate growth in healthy, middle-aged men without prostate disease: A randomized, placebo-controlled trial. Ann Intern Med. 153:621–632. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Kalinchenko SY, Tishova YA, Mskhalaya GJ, Gooren LJ, Giltay EJ and Saad F: Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: The double-blinded placebo-controlled Moscow study. Clin Endocrinol (Oxf). 73:602–612. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Srinivas-Shankar U, Roberts SA, Connolly MJ, O'Connell MD, Adams JE, Oldham JA and Wu FC: Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: A randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab. 95:639–650. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Kaufman JM, Miller MG, Garwin JL, Fitzpatrick S, McWhirter C and Brennan JJ: Efficacy and safety study of 1.62% testosterone gel for the treatment of hypogonadal men. J Sex Med. 8:2079–2089. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Shigehara K, Sugimoto K, Konaka H, Iijima M, Fukushima M, Maeda Y, Mizokami A, Koh E, Origasa H, Iwamoto T and Namiki M: Androgen replacement therapy contributes to improving lower urinary tract symptoms in patients with hypogonadism and benign prostate hypertrophy: A randomised controlled study. Aging Male. 14:53–58. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Frederiksen L, Højlund K, Hougaard DM, Brixen K and Andersen M: Testosterone therapy increased muscle mass and lipid oxidation in aging men. Age (Dordr). 34:145–156. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Ho CC, Tong SF, Low WY, Ng CJ, Khoo EM, Lee VK, Zainuddin ZM and Tan HM: A randomized, double-blind, placebo-controlled trial on the effect of long-acting testosterone treatment as assessed by the Aging Male Symptoms scale. BJU Int. 110:260–265. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Morgentaler A: Testosterone and prostate cancer: An historical perspective on a modern myth. Eur Urol. 50:935–939. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Moher D, Cook DJ, Eastwood S, Olkin I, Rennie D and Stroup F: Improving the Quality of Reports of Meta-Analyses of Randomised Controlled Trials: The QUOROM Statement. Onkologie. 23:597–602. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Oxman AD and Guyatt GH: The science of reviewing research. Ann N Y Acad Sci. 703:125–134. 1993. View Article : Google Scholar : PubMed/NCBI

25 

Bhasin S and Buckwalter JG: Testosterone supplementation in older men: A rational idea whose time has not yet come. J Androl. 22:718–731. 2001.PubMed/NCBI

26 

Smith MR: Changes in fat and lean body mass during androgen-deprivation therapy for prostate cancer. Urology. 63:742–745. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Mittan D, Lee S, Miller E, Perez RC, Basler JW and Bruder JM: Bone loss following hypogonadism in men with prostate cancer treated with GnRH analogs. J Clin Endocrinol Metab. 87:3656–3661. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Hackett G, Cole N, Bhartia M, Kennedy D, Raju J and Wilkinson P: BLAST Study Group: Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: The BLAST study. J Sex Med. 11:840–856. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Roehrborn CG, Siami P, Barkin J, Damião R, Major-Walker K, Nandy I, Morrill BB, Gagnier RP and Montorsi F: CombAT Study Group: The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study. Eur Urol. 57:123–131. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Kaplan SA: Re: The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study. J Urol. 185:1384–1385. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Hsing AW, Reichardt JK and Stanczyk FZ: Hormones and prostate cancer: Current perspectives and future directions. Prostate. 52:213–235. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Khera M, Bhattacharya RK, Blick G, Kushner H, Nguyen D and Miner MM: Changes in prostate specific antigen in hypogonadal men after 12 months of testosterone replacement therapy: Support for the prostate saturation theory. J Urol. 186:1005–1011. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Liao CH, Li HY, Chung SD, Chiang HS and Yu HJ: Significant association between serum dihydrotestosterone level and prostate volume among Taiwanese men aged 40–79 years. Aging Male. 15:28–33. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Raynaud JP, Gardette J, Rollet J and Legros JJ: Prostate-specific antigen (PSA) concentrations in hypogonadal men during 6 years of transdermal testosterone treatment. BJU Int. 111:880–890. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Ozata M, Bulur M, Beyhan Z, Sengül A, Saglam M, Turan M, Corakci A and Gundogan Ali M: Effects of gonadotropin and testosterone treatments on prostate volume and serum prostate specific antigen levels in male hypogonadism. Endocr J. 44:719–724. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Calof OM, Singh AB, Lee ML, Kenny AM, Urban RJ, Tenover JL and Bhasin S: Adverse events associated with testosterone replacement in middle-aged and older men: A meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci. 60:1451–1457. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo C, Gu W, Liu M, Peng B, Yao X, Yang B and Zheng J: Efficacy and safety of testosterone replacement therapy in men with hypogonadism: A meta-analysis study of placebo-controlled trials. Exp Ther Med 11: 853-863, 2016.
APA
Guo, C., Gu, W., Liu, M., Peng, B., Yao, X., Yang, B., & Zheng, J. (2016). Efficacy and safety of testosterone replacement therapy in men with hypogonadism: A meta-analysis study of placebo-controlled trials. Experimental and Therapeutic Medicine, 11, 853-863. https://doi.org/10.3892/etm.2015.2957
MLA
Guo, C., Gu, W., Liu, M., Peng, B., Yao, X., Yang, B., Zheng, J."Efficacy and safety of testosterone replacement therapy in men with hypogonadism: A meta-analysis study of placebo-controlled trials". Experimental and Therapeutic Medicine 11.3 (2016): 853-863.
Chicago
Guo, C., Gu, W., Liu, M., Peng, B., Yao, X., Yang, B., Zheng, J."Efficacy and safety of testosterone replacement therapy in men with hypogonadism: A meta-analysis study of placebo-controlled trials". Experimental and Therapeutic Medicine 11, no. 3 (2016): 853-863. https://doi.org/10.3892/etm.2015.2957
Copy and paste a formatted citation
x
Spandidos Publications style
Guo C, Gu W, Liu M, Peng B, Yao X, Yang B and Zheng J: Efficacy and safety of testosterone replacement therapy in men with hypogonadism: A meta-analysis study of placebo-controlled trials. Exp Ther Med 11: 853-863, 2016.
APA
Guo, C., Gu, W., Liu, M., Peng, B., Yao, X., Yang, B., & Zheng, J. (2016). Efficacy and safety of testosterone replacement therapy in men with hypogonadism: A meta-analysis study of placebo-controlled trials. Experimental and Therapeutic Medicine, 11, 853-863. https://doi.org/10.3892/etm.2015.2957
MLA
Guo, C., Gu, W., Liu, M., Peng, B., Yao, X., Yang, B., Zheng, J."Efficacy and safety of testosterone replacement therapy in men with hypogonadism: A meta-analysis study of placebo-controlled trials". Experimental and Therapeutic Medicine 11.3 (2016): 853-863.
Chicago
Guo, C., Gu, W., Liu, M., Peng, B., Yao, X., Yang, B., Zheng, J."Efficacy and safety of testosterone replacement therapy in men with hypogonadism: A meta-analysis study of placebo-controlled trials". Experimental and Therapeutic Medicine 11, no. 3 (2016): 853-863. https://doi.org/10.3892/etm.2015.2957
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