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Article

Effects of L‑carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial

  • Authors:
    • Mehmet Adnan Ozturk
    • Zehra Kardas
    • Fati̇h Kardas
    • Tamer Gunes
    • Seli̇m Kurtoglu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Division of Neonatology, Erciyes University, School of Medicine, Kayseri 38039, Turkey, Department of Pediatrics, State Educational and Research Hospital of The Government, Kayseri 38039, Turkey, Department of Pediatrics, Division of Pediatric Nutrition and Metabolism, Erciyes University, School of Medicine, Kayseri 38039, Turkey
  • Pages: 1123-1127
    |
    Published online on: December 29, 2015
       https://doi.org/10.3892/etm.2015.2964
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Abstract

The aim of the present study was to investigate the efficacy of L‑carnitine therapy on the occurrence and prognosis of respiratory distress syndrome (RDS). A single blind, randomized controlled trial study was conducted on 130 infants with gestational ages of 28‑36 weeks. Infants were assigned to experimental groups (groups 1 and 2) and control groups (groups 3 and 4). Groups 1 and 3 consisted of infants with RDS, and groups 2 and 4 groups were composed of infants without RDS. The experimental groups were treated with carnitine. No statistically significant differences in serum carnitine levels were detected between the study and the control groups on day 1 of treatment (P=0.06). However, on day 7 of treatment, serum carnitine levels in the experimental groups were significantly increased (P=0.02), as compared with the control groups. The surfactant requirement value, which is how many rounds of surfactant therapy were required, was 1.56±0.97 in group 1, and 2.12±0.99 in group 3 (P<0.001). The mean duration of mechanical ventilation required was 3.04±3.60 days in group 1, and 4.73±5.63 days in group 3 (P<0.001). The present results indicate that carnitine supplementation in premature infants with RDS may help to increase carnitine levels, thus decreasing the duration of mechanical ventilation and surfactant requirement.
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Copy and paste a formatted citation
Spandidos Publications style
Ozturk MA, Kardas Z, Kardas F, Gunes T and Kurtoglu S: Effects of L‑carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial. Exp Ther Med 11: 1123-1127, 2016.
APA
Ozturk, M.A., Kardas, Z., Kardas, F., Gunes, T., & Kurtoglu, S. (2016). Effects of L‑carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial. Experimental and Therapeutic Medicine, 11, 1123-1127. https://doi.org/10.3892/etm.2015.2964
MLA
Ozturk, M. A., Kardas, Z., Kardas, F., Gunes, T., Kurtoglu, S."Effects of L‑carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial". Experimental and Therapeutic Medicine 11.3 (2016): 1123-1127.
Chicago
Ozturk, M. A., Kardas, Z., Kardas, F., Gunes, T., Kurtoglu, S."Effects of L‑carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial". Experimental and Therapeutic Medicine 11, no. 3 (2016): 1123-1127. https://doi.org/10.3892/etm.2015.2964
Copy and paste a formatted citation
x
Spandidos Publications style
Ozturk MA, Kardas Z, Kardas F, Gunes T and Kurtoglu S: Effects of L‑carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial. Exp Ther Med 11: 1123-1127, 2016.
APA
Ozturk, M.A., Kardas, Z., Kardas, F., Gunes, T., & Kurtoglu, S. (2016). Effects of L‑carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial. Experimental and Therapeutic Medicine, 11, 1123-1127. https://doi.org/10.3892/etm.2015.2964
MLA
Ozturk, M. A., Kardas, Z., Kardas, F., Gunes, T., Kurtoglu, S."Effects of L‑carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial". Experimental and Therapeutic Medicine 11.3 (2016): 1123-1127.
Chicago
Ozturk, M. A., Kardas, Z., Kardas, F., Gunes, T., Kurtoglu, S."Effects of L‑carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial". Experimental and Therapeutic Medicine 11, no. 3 (2016): 1123-1127. https://doi.org/10.3892/etm.2015.2964
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