Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2016 Volume 11 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2016 Volume 11 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Increased expression of microRNA-503 and reduced expression of kangai-1 in B-cell non-Hodgkin's lymphoma

  • Authors:
    • Jingjing Wu
    • Aimin Li
    • Pengyu Zhang
    • Zhenchang Sun
    • Lijuan Han
    • Feifei Nan
    • Li Geng
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 917-922
    |
    Published online on: January 8, 2016
       https://doi.org/10.3892/etm.2016.2971
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to determine the expression levels of microRNA-503 (miR-503) and the tumor suppressor gene, kangai-1 (KAI1), in B‑cell non‑Hodgkin's lymphoma (B-NHL). A total of 45 patients with B-NHL (including 29 cases with stage III/IV disease and 16 cases with stage I/II disease) were enrolled in this study. In addition, 26 patients with reactive lymphoid hyperplasia (RLH) were enrolled as the control patients. Reverse transcription‑quantitative polymerase chain reaction was performed in order to measure the expression levels of miR‑503 in B‑NHL and RLH tissues, and to detect the expression levels of miR‑503 and KAI1 in peripheral blood samples. In addition, KAI1 expression levels in B‑NHL and RLH tissues were detected using western blotting and immunohistochemical analysis. The expression levels of miR‑503 were found to be significantly increased in the tissues and peripheral blood of B‑NHL patients when compared with those in RLH patients (P<0.05). However, KAI1 was strongly expressed in RLH tissues and weakly expressed in B‑NHL tissues. Furthermore, the expression levels of KAI1 were significantly decreased in the tissues and peripheral blood of B‑NHL patients when compared with those in the tissues and peripheral blood of RLH patients (P<0.05). The expression levels of miR‑503 in the tissues and peripheral blood of patients with stage III/IV B‑NHL were significantly higher compared with those with stage I/II B‑NHL (P<0.05). By contrast, the expression levels of KAI1 in stage III/IV B‑NHL tissues were significantly higher compared with those in stage I/II B‑NHL tissues (P<0.05). In conclusion, miR‑503 was highly expressed, whereas KAI1 was poorly expressed, in the tissues and peripheral blood of B-NHL patients. Thus, miR-503 may have an application as a novel therapeutic and diagnostic marker in B-NHL patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Nair VS, Pritchard CC, Tewari M and Ioannidis JP: Design and analysis for studying microRNAs in human disease: A primer on -omic technologies. Am J Epidemiol. 180:140–152. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Arora S, Swaminathan SK, Kirtane A, Srivastava SK, Bhardwaj A, Singh S, Panyam J and Singh AP: Synthesis, characterization and evaluation of poly (D,L-lactide-co-glycolide-based nanoformulation of miRNA-150: Potential implications for pancreatic cancer therapy. Int J Nanomedicine. 9:2933–2942. 2014.PubMed/NCBI

3 

Chen WX, Cai YQ, Lv MM, Chen L, Zhong SL, Ma TF, Zhao JH and Tang JH: Exosomes from docetaxel-resistant breast cancer cells alter chemosensitivity by delivering microRNAs. Tumour Biol. 35:9649–9659. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Guo J, Liu X and Wang M: miR-503 suppresses tumor cell proliferation and metastasis by directly targeting RNF31 in prostate cancer. Biochem Biophys Res Commun. 64:1302–3028. 2015. View Article : Google Scholar

5 

Li B, Liu L, Li X and Wu L: miR-503 suppresses metastasis of hepatocellular carcinoma cell by targeting PRMT1. Biochem Biophys Res Commun. 64:982–987. 2015. View Article : Google Scholar

6 

Xu YY, Wu HJ, Ma HD, Xu LP, Huo Y and Yin LR: MicroRNA-503 suppresses proliferation and cell-cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1. FEBS J. 280:3768–3779. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Lu YC, Chen YJ, Wang HM, Tsai CY, Chen WH, Huang YC, Fan KH, Tsai CN, Huang SF, Kang CJ, et al: Oncogenic function and early detection potential of miRNA-10b in oral cancer as identified by microRNA profiling. Cancer Prev Res (Phila). 5:665–674. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Zhou J, Tao Y, Peng C, Gu P and Wang W: miR-503 regulates metastatic function through Rho guanine nucleotide exchanger factor 19 in hepatocellular carcinoma. J Surg Res. 188:129–136. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Xiao F, Zhang W, Chen L, Chen F, Xie H, Xing C, Yu X, Ding S, Chen K, Guo H, et al: MicroRNA-503 inhibits the G1/S transition by downregulating cyclin D3 and E2F3 in hepatocellular carcinoma. J Transl Med. 11:1952013. View Article : Google Scholar : PubMed/NCBI

10 

Fukui T, Fukumoto K, Okasaka T, Kawaguchi K, Nakamura S, Hakiri S, Ozeki N, Hirakawa A, Tateyama H and Yokoi K: Clinical evaluation of a new tumour-node-metastasis staging system for thymic malignancies proposed by the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and the International Thymic Malignancy Interest Group. Eur J Cardiothorac Surg: Nov. 7:2015.(Epub ahead of print).

11 

Yang Y, Liu L, Zhang Y, Guan H, Wu J, Zhu X, Yuan J and Li M: MiR-503 targets PI3K p85 and IKK-β and suppresses progression of non-small cell lung cancer. Int J Cancer. 135:1531–1542. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Zhou L, Wu SW, Yu L, Song WQ, Cheng ZN and Wang DN: The expression of KAI1 in gastric adenocarcinoma and relationship with angiogenesis/lymphangiogenesis. Sichuan Da Xue Xue Bao Yi Xue Ban. 45:43–48. 2014.(In Chinese). PubMed/NCBI

13 

Liu X, Guo XZ, Li HY, Chen J, Ren LN and Wu CY: KAI1 inhibits lymphangiogenesis and lymphatic metastasis of pancreatic cancer in vivo. Hepatobiliary Pancreat Dis Int. 13:87–92. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Xiu B, Lin Y, Grote DM, Ziesmer SC, Gustafson MP, Maas ML, Zhang Z, Dietz AB, Porrata LF, Novak AJ, et al: IL-10 induces the development of immunosuppressive CD14(+)HLA-DR(low/-) monocytes in B-cell non-Hodgkin lymphoma. Blood Cancer J. 5:e3282015. View Article : Google Scholar : PubMed/NCBI

15 

Hua Q, Zhu Y and Liu H: Severe and fatal adverse events risk associated with rituximab addition to B-cell non-Hodgkin's lymphoma (B-NHL) chemotherapy: a meta-analysis. J Chemother. 2015.Apr 15: 1973947815Y0000000025. [Epub ahead of print]. View Article : Google Scholar : PubMed/NCBI

16 

Ghorbian S, Jahanzad I, Javadi GR and Sakhinia E: Evaluation diagnostic usefulness of immunoglobulin light chains (Igκ, Igλ) and incomplete IGH D-J clonal gene rearrangements in patients with B-cell non-Hodgkin lymphomas using BIOMED-2 protocol. Clin Transl Oncol. 16:1006–1011. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Scwab M: Ann Arbor Staging System. Encyclopedia of Cancer (2nd). (Berlin, Heidelberg). Springer Berlin Heidelberg. 169. 2009. View Article : Google Scholar

18 

Swerdlow SH, Campo E, Harris NL, et al: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 2:(4th). Lyon, France: IARC Press. 2008.

19 

Yamashita Y, Hasegawa M, Deng Z, Maeda H, Kondo S, Kyuna A, Matayoshi S, Agena S, Uehara T, Kouzaki H, et al: Human papillomavirus infection and immunohistochemical expression of cell cycle proteins pRb, p53, and p16(INK4a) in sinonasal diseases. Infect Agent Cancer. 10:232015. View Article : Google Scholar : PubMed/NCBI

20 

You J, Madigan MC, Rowe A, Sajinovic M, Russell PJ and Jackson P: An inverse relationship between KAI1 expression, invasive ability, and MMP-2 expression and activity in bladder cancer cell lines. Urol Oncol. 30:502–508. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Altman T, Travers M, Kothari A, Caspi R and Karp PD: A systematic comparison of the MetaCyc and KEGG pathway databases. BMC Bioinformatics. 14:1122013. View Article : Google Scholar : PubMed/NCBI

22 

Sekimzu M, Mori T, Kikuchi A, Mitsui T, Sunami S, Kobayashi R, Fujita N, Inada H, Takimoto T, Saito AM, et al: Prognostic impact of cytogenetic abnormalities in children and adolescents with mature B-cell non-Hodgkin lymphoma: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG). Pediatr Blood Cancer. 62:1294–1296. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Bruni R, Marcantonio C, Pulsoni A, Tataseo P, De Angelis F, Spada E, Marcucci F, Panfilio S, Bianco P, Riminucci M, et al: microRNA levels in paraffin-embedded indolent B-cell non-Hodgkin lymphoma tissues from patients chronically infected with hepatitis B or C virus. BMC Infect Dis 14 Suppl. 5:S62014. View Article : Google Scholar

24 

Song A, Ye J, Zhang K, Yu H, Gao Y, Wang H, Sun L, Xing X, Yang K and Zhao M: Aberrant expression of the CHFR prophase checkpoint gene in human B-cell non-Hodgkin lymphoma. Leuk Res. 39:536–543. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Wang K, Jiang Y, Zheng W, Liu Z, Li H, Lou J, Gu M and Wang X: Silencing of Human Phosphatidylethanolamine-Binding Protein 4 Enhances Rituximab-Induced Death and Chemosensitization in B-Cell Lymphoma. PLoS One. 8:e568292013. View Article : Google Scholar : PubMed/NCBI

26 

Di Lisio L, Sánchez-Beato M, Gómez-López G, Rodríguez ME, Montes-Moreno S, Mollejo M, Menárguez J, Martínez MA, Alves FJ, Pisano DG, et al: MicroRNA signatures in B-cell lymphomas. Blood Cancer J. 2:e572012. View Article : Google Scholar : PubMed/NCBI

27 

Tagawa H, Ikeda S and Sawada K: Role of microRNA in the pathogenesis of malignant lymphoma. Cancer Sci. 104:801–809. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Peng Y, Liu YM, Li LC, Wang LL and Wu XL: microRNA-503 inhibits gastric cancer cell growth and epithelial-to-mesenchymal transition. Oncol Lett. 7:1233–1238. 2014.PubMed/NCBI

29 

Maurer CA, Graber HU, Friess H, Beyermann B, Willi D, Netzer P, Zimmermann A and Büchler MW: Reduced expression of the metastasis suppressor gene KAI1 in advanced colon cancer and its metastases. Surgery. 126:869–880. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Guo X, Friess H, Graber HU, Kashiwagi M, Zimmermann A, Korc M and Büchler MW: KAI1 expression is up-regulated in early pancreatic cancer and decreased in the presence of metastases. Cancer Res. 56:4876–4880. 1996.PubMed/NCBI

31 

Yang JL, Jackson P, Yu Y, Russell PJ, Markovic B and Crowe PJ: Expression of the KAI1 metastasis suppressor gene in non-metastatic vs. metastatic human colorectal cancer. Anticancer Res. 22:3337–3342. 2002.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu J, Li A, Zhang P, Sun Z, Han L, Nan F and Geng L: Increased expression of microRNA-503 and reduced expression of kangai-1 in B-cell non-Hodgkin's lymphoma. Exp Ther Med 11: 917-922, 2016.
APA
Wu, J., Li, A., Zhang, P., Sun, Z., Han, L., Nan, F., & Geng, L. (2016). Increased expression of microRNA-503 and reduced expression of kangai-1 in B-cell non-Hodgkin's lymphoma. Experimental and Therapeutic Medicine, 11, 917-922. https://doi.org/10.3892/etm.2016.2971
MLA
Wu, J., Li, A., Zhang, P., Sun, Z., Han, L., Nan, F., Geng, L."Increased expression of microRNA-503 and reduced expression of kangai-1 in B-cell non-Hodgkin's lymphoma". Experimental and Therapeutic Medicine 11.3 (2016): 917-922.
Chicago
Wu, J., Li, A., Zhang, P., Sun, Z., Han, L., Nan, F., Geng, L."Increased expression of microRNA-503 and reduced expression of kangai-1 in B-cell non-Hodgkin's lymphoma". Experimental and Therapeutic Medicine 11, no. 3 (2016): 917-922. https://doi.org/10.3892/etm.2016.2971
Copy and paste a formatted citation
x
Spandidos Publications style
Wu J, Li A, Zhang P, Sun Z, Han L, Nan F and Geng L: Increased expression of microRNA-503 and reduced expression of kangai-1 in B-cell non-Hodgkin's lymphoma. Exp Ther Med 11: 917-922, 2016.
APA
Wu, J., Li, A., Zhang, P., Sun, Z., Han, L., Nan, F., & Geng, L. (2016). Increased expression of microRNA-503 and reduced expression of kangai-1 in B-cell non-Hodgkin's lymphoma. Experimental and Therapeutic Medicine, 11, 917-922. https://doi.org/10.3892/etm.2016.2971
MLA
Wu, J., Li, A., Zhang, P., Sun, Z., Han, L., Nan, F., Geng, L."Increased expression of microRNA-503 and reduced expression of kangai-1 in B-cell non-Hodgkin's lymphoma". Experimental and Therapeutic Medicine 11.3 (2016): 917-922.
Chicago
Wu, J., Li, A., Zhang, P., Sun, Z., Han, L., Nan, F., Geng, L."Increased expression of microRNA-503 and reduced expression of kangai-1 in B-cell non-Hodgkin's lymphoma". Experimental and Therapeutic Medicine 11, no. 3 (2016): 917-922. https://doi.org/10.3892/etm.2016.2971
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team