Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2016 Volume 11 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2016 Volume 11 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Circulating microRNA profile in patients with membranous obstruction of the inferior vena cava

  • Authors:
    • Gui‑Xiang Sun
    • Yong Su
    • Ying Li
    • Ya‑Feng Zhang
    • Li‑Chun Xu
    • Mao‑Heng Zu
    • Shui‑Ping Huang
    • Jin‑Peng Zhang
    • Zhao‑Jun Lu
  • View Affiliations / Copyright

    Affiliations: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu 221004, P.R. China, Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221004, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 811-817
    |
    Published online on: January 12, 2016
       https://doi.org/10.3892/etm.2016.2981
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Membranous obstruction of the inferior vena cava (MOVC) is a common type of Budd-Chiari syndrome. However, the pathogenesis of MOVC has not been fully elucidated. Recent studies demonstrated that microRNAs (miRNAs or miRs) are involved in multiple diseases. To the best of our knowledge, specific changes in the expression of miRNAs in MOVC patients have not been previously assessed. The present study used a microarray analysis, followed by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) validation, with the aim to access the miRNA expression levels in the plasma of 34 MOVC patients, compared with those in healthy controls. The results revealed a total of 16 differentially expressed miRNAs in MOVC patients. Subsequently, RT‑qPCR analysis verified the statistically consistent expression of 5 selected miRNAs (miR‑125a‑5p, miR‑133b, miR‑423‑5p, miR‑1228‑5p and miR‑1266), in line with the results of the microarray analysis. These 5 miRNAs, which were described as crucial regulators in numerous biological processes and vascular diseases, may play an important role in the pathogenesis of MOVC. Bioinformatics analysis of target genes of the differentially expressed miRNAs revealed that these predicted targets were significantly enriched and involved in several key signaling pathways important for MOVC, including the ErbB, Wnt, MAPK and VEGF signaling pathway. In conclusion, miRNAs may involve in multiple signaling pathways contributing to the pathological processes of MOVC. The present study offers an intriguing new perspective on the involvement of miRNAs in MOVC; however, the precise underlying mechanisms require further validation.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Valla DC: Primary Budd-Chiari syndrome. J Hepatol. 50:195–203. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Hefaiedh R, Cheikh M, Marsaoui L, Ennaifer R, Romdhane H, Ben Nejma H, Bel Hadj N, Arfa N and Khalfallah MT: The Budd-Chiari syndrome. Tunis Med. 91:376–381. 2013.PubMed/NCBI

3 

Leebeek FW, Smalberg JH and Janssen HL: Prothrombotic disorders in abdominal vein thrombosis. Neth J Med. 70:400–405. 2012.PubMed/NCBI

4 

Plessier A, Rautou PE and Valla DC: Management of hepatic vascular diseases. J Hepatol. 56:S25–S38. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Plessier A and Valla DC: Budd-Chiari syndrome. Semin Liver Dis. 28:259–269. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Qi X, Han G, Wu F, Ren W, He C, Yin Z, Niu J, Bai M, Yang Z, Wu K and Fan D: Thrombotic risk factors in Chinese Budd-Chiari syndrome patients. An observational study with a systematic review of the literature. Thromb Haemost. 109:878–884. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Cheng D, Xu H, Lu ZJ, Hua R, Qiu H, Du H, Xu X and Zhang J: Clinical features and etiology of Budd-Chiari syndrome in Chinese patients: A single. center study. J Gastroenterol Hepatol. 28:1061–1067. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Murad Darwish S, Plessier A, Hernandez-Guerra M, Fabris F, Eapen CE, Bahr MJ, Trebicka J, Morard I, Lasser L, Heller J, et al: EN-Vie (European Network for Vascular Disorders of the Liver): Etiology, management and outcome of the Budd-Chiari syndrome. Ann Intern Med. 151:167–175. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Smalberg JH, Arends LR, Valla DC, Kiladjian JJ, Janssen HL and Leebeek FW: Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: A meta-analysis. Blood. 120:4921–4928. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Okuda K: Membranous obstruction of the inferior vena cava (obliterative hepatocavopathy, Okuda). J Gastroenterol Hepatol. 16:1179–1183. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Wang ZG, Zhang FJ, Yi MQ and Qiang LX: Evolution of management for Budd-Chiari syndrome: A team's view from 2564 patients. ANZ J Surg. 75:55–63. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Qi X, Zhang C, Han G, Zhang W, He C, Yin Z, Liu Z, Bai W, Li R, Bai M, et al: Prevalence of the JAK2V617F mutation in Chinese patients with Budd-Chiari syndrome and portal vein thrombosis: A prospective study. J Gastroenterol Hepatol. 27:1036–1043. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Wang H, Sun G, Zhang P, Zhang J, Gui E, Zu M, Jia E, Xu H, Xu L, Zhang J and Lu Z: JAK2 V617F mutation and 46/1 haplotype in Chinese Budd-Chiari syndrome patients. J Gastroenterol Hepatol. 29:208–214. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Valla DC: Hepatic venous outflow tract obstruction etiopathogenesis: Asia versus the West. J Gastroenterol Hepatol. 19:S204–S211. 2004. View Article : Google Scholar

15 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Urbich C, Kuehbacher A and Dimmeler S: Role of microRNAs in vascular diseases, inflammation and angiogenesis. Cardiovasc Res. 79:581–588. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Small EM and Olson EN: Pervasive roles of microRNAs in cardiovascular biology. Nature. 469:336–342. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Yue J, Guan J, Wang X, Zhang L, Yang Z, Ao Q, Deng Y, Zhu P and Wang G: MicroRNA-206 is involved in hypoxia-induced pulmonary hypertension through targeting of the HIF-1α/Fhl-1 pathway. Lab Invest. 93:748–759. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Icli B, Wara AK, Moslehi J, Sun X, Plovie E, Cahill M, Marchini JF, Schissler A, Padera RF, Shi J, et al: MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling. Circ Res. 113:1231–1241. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Zhao Z, Zhao Q, Warrick J, Lockwood CM, Woodworth A, Moley KH and Gronowski AM: Circulating microRNA miR-323-3p as a biomarker of ectopic pregnancy. Clin Chem. 58:896–905. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Tan L, Yu JT, Liu QY, Tan MS, Zhang W, Hu N, Wang YL, Sun L and Jiang T: Circulating miR-125b as a biomarker of Alzheimer's disease. J Neurol Sci. 336:52–56. 2014. View Article : Google Scholar : PubMed/NCBI

23 

El-Hefnawy T, Raja S, Kelly L, Bigbee WL, Kirkwood JM, Luketich JD and Godfrey TE: Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics. Clin Chem. 50:564–573. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, et al: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 105:10513–10518. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Ach RA, Wang H and Curry B: Measuring microRNAs: Comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods. BMC Biotechno. 8:692008. View Article : Google Scholar

26 

Kroh EM, Parkin RK, Mitchell PS and Tewari M: Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR). Methods. 50:298–301. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Li D, Yang P, Xiong Q, Song X, Yang X, Liu L, Yuan W and Rui YC: MicroRNA-125a/b-5p inhibits endothelin-1 expression in vascular endothelial cells. J Hypertens. 28:1646–1654. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Wang E, Nie Y, Zhao Q, Wang W, Huang J, Liao Z, Zhang H, Hu S and Zheng Z: Circulating miRNAs reflect early myocardial injury and recovery after heart transplantation. J Cardiothorac Surg. 8:1652013. View Article : Google Scholar : PubMed/NCBI

30 

Tijsen AJ, Creemers EE, Moerland PD, de Windt LJ, van der Wal AC, Kok WE and Pinto YM: MiR423-5p as a circulating biomarker for heart failure. Circ Res. 106:1035–1039. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Chen L, Lu MH, Zhang D, Hao NB, Fan YH, Wu YY, Wang SM, Xie R, Fang DC, Zhang H, et al: miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase. Cell Death Dis. 5:e10342014. View Article : Google Scholar : PubMed/NCBI

32 

Jia L, Wu J, Zhang L, Chen J, Zhong D, Xu S, Xie C and Cai J: Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer. PLoS One. 8:e586372013. View Article : Google Scholar : PubMed/NCBI

33 

Fu Y, Yi Z, Wu X, Li J and Xu F: Circulating microRNAs in patients with active pulmonary tuberculosis. J Clin Microbiol. 49:4246–4251. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Li D, Yang P, Xiong Q, Song X, Yang X, Liu L, Yuan W and Rui YC: MicroRNA-125a/b-5p inhibits endothelin-1 expression in vascular endothelial cells. J Hypertens. 28:1646–1654. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Reijerkerk A, Lopez-Ramirez MA, van Het Hof B, Drexhage JA, Kamphuis WW, Kooij G, Vos JB, van der Pouw Kraan TC, van Zonneveld AJ, Horrevoets AJ, et al: MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: Implications for multiple sclerosis. J Neurosci. 33:6857–6863. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Che P, Liu J, Shan Z, Wu R, Yao C, Cui J, Zhu X and Wang J, Burnett MS, Wang S and Wang J: MiR-125a-5p impairs endothelial cell angiogenesis in aging mice via RTEF-1 downregulation. Aging Cell. 13:926–934. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Hao L, Wang XG, Cheng JD, You SZ, Ma SH, Zhong X, Quan L and Luo B: The up-regulation of endothelin-1 and down-regulation of miRNA-125a-5p, −155 and −199a/b-3p in human atherosclerotic coronary artery. Cardiovasc Pathol. 23:217–223. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Dashwood MR and Tsui JC: Endothelin-1 and atherosclerosis: Potential complications associated with endothelin-receptor blockade. Atherosclerosis. 160:297–304. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Kowala MC: The role of endothelin in the pathogenesis of atherosclerosis. Adv Pharmacol. 37:299–318. 1997. View Article : Google Scholar : PubMed/NCBI

40 

Zhao H, Li M, Li L, Yang X, Lan G and Zhang Y: MiR-133b is down-regulated in human osteosarcoma and inhibits osteosarcoma cells proliferation, migration and invasion and promotes apoptosis. PLoS One. 8:e835712013. View Article : Google Scholar : PubMed/NCBI

41 

Zhao Y, Huang J, Zhang L, Qu Y, Li J, Yu B, Yan M, Yu Y, Liu B and Zhu Z: MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells. BMC Cancer. 14:342014. View Article : Google Scholar : PubMed/NCBI

42 

Wang E, Nie Y, Zhao Q, Wang W, Huang J, Liao Z, Zhang H, Hu S and Zheng Z: Circulating miRNAs reflect early myocardial injury and recovery after heart transplantation. J Cardiothorac Surg. 8:1652013. View Article : Google Scholar : PubMed/NCBI

43 

Tijsen AJ, Creemers EE, Moerland PD, de Windt LJ, van der Wal AC, Kok WE and Pinto YM: MiR423-5p as a circulating biomarker for heart failure. Circ Res. 106:1035–1039. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Chen L, Lü MH, Zhang D, Hao NB, Fan YH, Wu YY, Wang SM, Xie R, Fang DC, Zhang H, et al: MiR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase. Cell Death Dis. 5:e10342014. View Article : Google Scholar : PubMed/NCBI

45 

Jia L, Wu J, Zhang L, Chen J, Zhong D, Xu S, Xie C and Cai J: Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer. PLoS One. 8:e586372013. View Article : Google Scholar : PubMed/NCBI

46 

Pentassuglia L and Sawyer DB: ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions. Biochim Biophys Acta. 1833:909–916. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Koziński K and Dobrzyń A: Wnt signaling pathway-its role in regulation of cell metabolism. Postepy Hig Med Dosw (Online). 67:1098–1108. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Siddiqui SS, Siddiqui ZK, Uddin S, Minshall RD and Malik AB: P38 MAPK activation coupled to endocytosis is a determinant of endothelial monolayer integrity. Am J Physiol Lung Cell Mol Physiol. 292:L114–L124. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Liang X, Xu F, Li X, Ma C, Zhang Y and Xu W: VEGF signal system: The application of antiangiogenesis. Curr Med Chem. 21:894–910. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Shibuya M: Vascular endothelial growth factor and its receptor system: Physiological functions in angiogenesis and pathological roles in various diseases. J Biochem. 153:13–19. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun GX, Su Y, Li Y, Zhang YF, Xu LC, Zu MH, Huang SP, Zhang JP and Lu ZJ: Circulating microRNA profile in patients with membranous obstruction of the inferior vena cava. Exp Ther Med 11: 811-817, 2016.
APA
Sun, G., Su, Y., Li, Y., Zhang, Y., Xu, L., Zu, M. ... Lu, Z. (2016). Circulating microRNA profile in patients with membranous obstruction of the inferior vena cava. Experimental and Therapeutic Medicine, 11, 811-817. https://doi.org/10.3892/etm.2016.2981
MLA
Sun, G., Su, Y., Li, Y., Zhang, Y., Xu, L., Zu, M., Huang, S., Zhang, J., Lu, Z."Circulating microRNA profile in patients with membranous obstruction of the inferior vena cava". Experimental and Therapeutic Medicine 11.3 (2016): 811-817.
Chicago
Sun, G., Su, Y., Li, Y., Zhang, Y., Xu, L., Zu, M., Huang, S., Zhang, J., Lu, Z."Circulating microRNA profile in patients with membranous obstruction of the inferior vena cava". Experimental and Therapeutic Medicine 11, no. 3 (2016): 811-817. https://doi.org/10.3892/etm.2016.2981
Copy and paste a formatted citation
x
Spandidos Publications style
Sun GX, Su Y, Li Y, Zhang YF, Xu LC, Zu MH, Huang SP, Zhang JP and Lu ZJ: Circulating microRNA profile in patients with membranous obstruction of the inferior vena cava. Exp Ther Med 11: 811-817, 2016.
APA
Sun, G., Su, Y., Li, Y., Zhang, Y., Xu, L., Zu, M. ... Lu, Z. (2016). Circulating microRNA profile in patients with membranous obstruction of the inferior vena cava. Experimental and Therapeutic Medicine, 11, 811-817. https://doi.org/10.3892/etm.2016.2981
MLA
Sun, G., Su, Y., Li, Y., Zhang, Y., Xu, L., Zu, M., Huang, S., Zhang, J., Lu, Z."Circulating microRNA profile in patients with membranous obstruction of the inferior vena cava". Experimental and Therapeutic Medicine 11.3 (2016): 811-817.
Chicago
Sun, G., Su, Y., Li, Y., Zhang, Y., Xu, L., Zu, M., Huang, S., Zhang, J., Lu, Z."Circulating microRNA profile in patients with membranous obstruction of the inferior vena cava". Experimental and Therapeutic Medicine 11, no. 3 (2016): 811-817. https://doi.org/10.3892/etm.2016.2981
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team