Large hemorrhage due to venipuncture in the elbow of a patient with severe hemophilia: A case report and literature review

Lyu,Jingtong; Wu,Wenjie; Xiang,Zhou; Huang,Fuguo

doi:10.3892/etm.2016.2990

March-2016 Volume 11 Issue 3

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

March-2016 Volume 11 Issue 3

Full Size Image

Case Report

Large hemorrhage due to venipuncture in the elbow of a patient with severe hemophilia: A case report and literature review

Authors:
- Jingtong Lyu
- Wenjie Wu
- Zhou Xiang
- Fuguo Huang
View Affiliations / Copyright

Affiliations: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan 610064, P.R. China
Pages: 1023-1026
|
Published online on: January 13, 2016

https://doi.org/10.3892/etm.2016.2990
Expand metrics +

Abstract

Hemophilia A, which is the most common form of hemophilia, is caused by a deficiency of clotting factor VIII. The incidence of hemophilia A is 1:10,000 people worldwide. The most common complication associated with hemophilia A is bleeding into joints, predominantly the knees, ankles, and elbows, which may lead to destruction or osteoarthritis of the specific joint. Various degrees of disability may follow these initial or recurrent hemorrhages. Subsequent to improvements in medical management, patients with hemophilia A currently have a life expectancy similar to that of the normal population. However, the management of patients with hemophilia A remains a clinical challenge for various reasons, including the lack of reliable and cost‑effective treatment, and the high risk of intra‑ or post‑operative hemorrhages. Large hemorrhages due to the phlebotomizing of young patients are very rare. To the best of our knowledge, the present case is the first report regarding the occurrence of a large hemorrhage due to venipuncture in the elbow of a patient with hemophilia A, and discusses the pathogenesis, clinical manifestation, and the medico‑chirurgical treatment of this patient.

View Figures

View References

1	Petrini P: Treatment strategies in children with hemophilia. Pediatr Drugs. 4:427–437. 2002. View Article : Google Scholar
2	Martínez-Lage JF, Torroba MA, Cuartero Pérez B, Almagro MJ, López-Guerrero López A and de la Rosa P: Cavernous hemangiomas of the cranial vault in infants: A case-based update. Childs Nerv Syst. 26:861–865. 2010. View Article : Google Scholar : PubMed/NCBI
3	Cosar M, Eser O, Aslan A, Korkmaz S, Boyaci G and Aktepe F: Intradiploic cavernous hemangioma of the skull in a child: A case report. Childs Nerv Syst. 24:975–977. 2008. View Article : Google Scholar : PubMed/NCBI
4	Politi M, Romeike BF, Papanagiotou P, Nabhan A, Struffert T, Feiden W and Reith W: Intraosseous hemangioma of the skull with dural tail sign: Radiologic features with pathologic correlation. AJNR Am J Neuroradiol. 26:2049–2052. 2005.PubMed/NCBI
5	Giangrande PLF: Management of haemophilia. Pead Child Healt. 21:344–347. 2011. View Article : Google Scholar
6	Sperr WR, Lechner K and Pabinger I: Rituximab for the treatment of acquired antibodies to factor VIII. Haematologica. 92:66–71. 2007. View Article : Google Scholar : PubMed/NCBI
7	Zhong W, Li G, Huang S, Chen H and You C: Intradiploic hemangioma with repeated hemorrhage in a child with hemophilia. J Neurosurg Pediatr. 10:56–59. 2012. View Article : Google Scholar : PubMed/NCBI
8	Shih SL, Lin JC, Liang DC and Huang JK: Computed tomography of spontaneous intracranial haemorrhage due to haemostatic disorders in children. Neuroradiology. 35:619–621. 1993. View Article : Google Scholar : PubMed/NCBI
9	Taylor CL, Selman WR and Ratcheson RA: Brain attack. The emergent management of hypertensive hemorrhage. Neurosurg Clin N Am. 8:237–244. 1997.PubMed/NCBI
10	Rangarajan S, Yee T and Wilde J: Experience of four UK comprehensive care centres using FEIBA® for surgeries in patients with inhibitors. Haemophilia. 17:28–34. 2011. View Article : Google Scholar : PubMed/NCBI
11	Lauroua P, Ferrer AM and Guérin V: Successful major and minor surgery using factor VIII inhibitor bypassing activity in patients with haemophilia A and inhibitors. Haemophilia. 15:1300–1307. 2009. View Article : Google Scholar : PubMed/NCBI
12	Lak M, Sharifian RA, Karimi K and Mansouritorghabeh H: Acquired hemophilia. A. Clinical features, surgery and treatment of 34 cases, and experience of using recombinant factor VIIa. Clin Appl Thromb Hemost. 16:294–300. 2010. View Article : Google Scholar : PubMed/NCBI
13	Kam G, Lee YS, Tan TT, Chow P and Ng HJ: Surgery-associated acquired haemophilia and response to combined rituximab and cyclosporine treatment. Haemophilia. 17:715–716. 2011. View Article : Google Scholar : PubMed/NCBI
14	Mahlangu JN and Gilham A: Medical and Scientific Advisory Council of the South African Haemophilia Foundation: Guideline for treatment of haemophilia in South Africa. S Afr Med J. 98:126–140. 2008.PubMed/NCBI
15	Lak M, Sharifian RA, Karimi K and Mansouritorghabeh H: Acquired Hemophilia A. Clinical features, surgery and treatment of 34 Cases, and experience of using recombinant factor VIIa. Clin Appl Thromb Hemost. 16:294–300. 2010. View Article : Google Scholar : PubMed/NCBI
16	Huth-Kühne A, Baudo F, Collins P, Ingerslev J, Kessler CM, Lévesque H, Castellano ME, Shima M and St-Louis J: International recommendations on the diagnosis and treatment of patients with acquired hemophilia A. Haematologica. 94:566–575. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Large hemorrhage due to venipuncture in the elbow of a patient with severe hemophilia: A case report and literature review

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Related Articles