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Article

Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion

  • Authors:
    • Lei Feng
    • Jun Liu
    • Yunzhen Liu
    • Jian Chen
    • Chunhai Su
    • Chuanfeng Lv
    • Yuzhen Wei
  • View Affiliations / Copyright

    Affiliations: Department of Neurovascular Surgery, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China, Department of Clinical Pharmacy, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China
  • Pages: 1011-1016
    |
    Published online on: January 14, 2016
       https://doi.org/10.3892/etm.2016.2995
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Abstract

The aims of the present study were to establish a model of embolic stroke in rabbits and to evaluate the efficacy and safety of intra‑arterially administered tirofiban combined with urokinase thrombolysis. The middle cerebral artery occlusion model (MCAO) of embolic stroke was established in New Zealand rabbits via an autologous clot. The model rabbits were allocated at random into four groups: Tirofiban group (T group), urokinase group (UK group), tirofiban and urokinase group (T + UK group) and the control group (C group). The recanalization rate, relative‑apparent diffusion coefficient (rADC) and neurological function deficit score (NFDS) values were compared among the four groups. The recanalization rate, rADC and NFDS values were improved in the T + UK group compared with the other groups. In summary, the intra‑arterial administration of tirofiban combined with urokinase thrombolysis was a more effective intervention in an MCAO model compared with intra‑arterial urokinase alone, and may promote reperfusion and reduce infarct volume.
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1 

Gaillard N, Schmidt C, Costalat V, et al: Hemorrhagic risk of recent silent cerebral infarct on prethrombolysis MR imaging in acute stroke. AJNR Am J Neuroradiol. 33:227–231. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Sung SM, Lee TH, Cho HJ, Sol YL, Park KH, Jung DS and Kim CW: Recanalization with Wingspan stent for acute middle cerebral artery occlusion in failure or contraindication to intravenous thrombolysis: A feasibility study. AJNR Am J Neuroradiol. 33:1156–1161. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Kellert L, Hametner C, Rohde S, Bendszus M, Hacke W, Ringleb P and Stampfl S: Endovascular stroke therapy tirofiban is associated with risk of fatal intracerebral hemorrhage and poor outcome. Stroke. 44:1453–1455. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Mullen MT, Pisapia JM, Tilwa S, Messé SR and Stein SC: Systematic review of outcome after ischemic stroke due to anterior circulation occlusion treated with intravenous, intra-arterial, or combined intravenous+intra-arterial thrombolysis. Stroke. 43:2350–2355. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Xu XQ, Zu QQ, Lu SS, et al: Use of FLAIR imaging to identify onset time of cerebral ischemia in a canine model. ANJR Am J Neuroradiol. 35:311–316. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Siebler M, Hennerici MG, Schneider D, et al: Safety of Tirofiban in acute ischemic Stroke: The SaTIS trial. Stroke. 42:2388–2392. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Georgiadis AL, Memon MZ, Shah QA, Vazquez G, Suri MF, Lakshminarayan K and Qureshi AI: Comparison of partial (6 mg/kg) versus full-dose (9 mg/kg) intravenous recombinant tissue plasminogen activator followed by endovascular treatment for acute ischemic stroke: A meta-analysis. J Neuroimaging. 21:113–120. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Zhang L, Zhang ZG, Zhang R, Morris D, Lu M, Coller BS and Chopp M: Adjuvant treatment with a glycoprotein IIb/IIIa receptor inhibitor increases the therapeutic window for low-dose tissue plasminogen activator administration in a rat model of embolic stroke. Circulation. 107:2837–2843. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Junghans U, Seitz R, Ritzl A, Wittsack HJ, Fink GR, Freund HJ and Siebler M: Ischemic brain tissue salvaged from infarction by the GP II b/III a platelet antagonist tirofiban. Neurology. 58:474–476. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Baik SK, Oh SJ, Park KP and Lee JH: Intra-arterial tirofiban infusion for partial recanalization with stagnant flow in hyperacute cerebral ischemic stroke. Interv Neuroradiol. 17:442–451. 2011.PubMed/NCBI

11 

Ottani F, La Vecchia L, De Vita M, Catapano O, Tarantino F and Galvani M: Comparison by meta-analysis of eptifibatide and tirofiban to abciximab in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. Am J Cardiol. 106:167–174. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Schiariti M, Saladini A, Cuturello D, Missiroli B and Puddu PE: Long-term efficacy of high-dose tirofiban versus double-bolus eptifibatide in patients undergoing percutaneous coronary intervention. J Cardiovasc Med (Hagerstown). 12:29–36. 2011.PubMed/NCBI

13 

Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL and Bartkowksi H: Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination. Stroke. 17:472–476. 1986. View Article : Google Scholar : PubMed/NCBI

14 

Bhatia R, Hill MD, Shobha N, et al: Low rates of acute recanalization with intravenous recombinant tissue plasminogen activator in ischemic stroke: Real-world experience and a call for action. Stroke. 41:2254–2258. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Zangerle A, Kiechl S, Spiegel M, et al: Recanalization after thrombolysis in stroke patients: Predictors and prognostic implications. Neurology. 68:39–44. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Rha JH and Saver JL: The impact of recanalization on ischemic stroke outcome: A meta-analysis. Stroke. 38:967–973. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Mangiafico S, Cellerini M, Nencini P, Gensini G and Inzitari D: Intravenous glycoprotein IIb/IIIa inhibitor (tirofiban) followed by intra-arterial urokinase and mechanical thrombolysis in stroke. AJNR Am J Neuroradiol. 26:2595–2601. 2005.PubMed/NCBI

18 

Shuaib A, Yang Y, Nakada MT, Li Q and Yang T: Glycoprotein IIb/IIIa antagonist, murine 7E3 F (ab') 2 and tissue plasminogen activator in focal ischemia: Evaluation of efficacy and risk of hemorrhage with combination therapy. J Cereb Blood Flow Metab. 22:215–222. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Jeon JS, Sheen SH, Hwang G, Kang SH, Heo DH and Cho YJ: Intraarterial tirofiban thrombolysis for thromboembolisms during coil embolization for ruptured intracranial aneurysms. J Cerebrovasc Endovasc Neurosurg. 14:5–10. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Jeong HW and Jin SC: Intra-arterial infusion of a glycoprotein IIb/IIIa antagonist for the treatment of thromboembolism during coil embolization of intracranial aneurysm: A comparison of abciximab and tirofiban. AJNR Am J Neuroradiol. 34:1621–1625. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Chen MH, Wu SL, Lo MC, Chen WL and Wang WF: Basilar artery occlusion in a teenaged boy treated with intra-arterial thrombolysis. Acta Neurol Taiwan. 19:281–286. 2010.PubMed/NCBI

22 

Kwon BJ, Seo DH, Ha YS and Lee KC: Endovascular treatment of wide-necked cerebral aneurysms with an acute angle branch incorporated into the Sac: Novel methods of branch access in 8 aneurysms. Neurointervention. 7:93–101. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Rho MH, Kim BM, Suh SH, Kim DJ and Kim DI: Initial experience with the new double-lumen scepter balloon catheter for treatment of wide-necked aneurysms. Korean J Radiol. 14:832–840. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Cho YD, Lee JY, Seo JH, Kang HS, Kim JE, Jung KH and Han MH: Intra-arterial tirofiban infusion for thromboembolic complication during coil embolization of ruptured intracranial aneurysms. Eur J Radiol. 81:2833–2838. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Won YS, Rho MH, Kim BM, Park HJ, Kwag HJ and Chung EC: Various techniques of stent-assisted coil embolization of wide-necked or fusiform middle cerebral artery aneurysms: initial and mid-term results. J Korean Neurosurg Soc. 53:274–280. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Lang SH, Manning N, Armstrong N, Misso K, Allen A, Di Nisio M and Kleijnen J: Treatment with tirofiban for acute coronary syndrome (ACS): A systematic review and network analysis. Curr Med Res Opin. 28:351–370. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Syfret DA, Mitchell P, Dowling R and Yan B: Does intra-arterial thrombolysis have a role as first-line intervention in acute ischaemic stroke. Intern Med J. 41:220–226. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Feng L, Liu J, Liu Y, Chen J, Su C, Lv C and Wei Y: Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion. Exp Ther Med 11: 1011-1016, 2016.
APA
Feng, L., Liu, J., Liu, Y., Chen, J., Su, C., Lv, C., & Wei, Y. (2016). Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion. Experimental and Therapeutic Medicine, 11, 1011-1016. https://doi.org/10.3892/etm.2016.2995
MLA
Feng, L., Liu, J., Liu, Y., Chen, J., Su, C., Lv, C., Wei, Y."Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion". Experimental and Therapeutic Medicine 11.3 (2016): 1011-1016.
Chicago
Feng, L., Liu, J., Liu, Y., Chen, J., Su, C., Lv, C., Wei, Y."Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion". Experimental and Therapeutic Medicine 11, no. 3 (2016): 1011-1016. https://doi.org/10.3892/etm.2016.2995
Copy and paste a formatted citation
x
Spandidos Publications style
Feng L, Liu J, Liu Y, Chen J, Su C, Lv C and Wei Y: Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion. Exp Ther Med 11: 1011-1016, 2016.
APA
Feng, L., Liu, J., Liu, Y., Chen, J., Su, C., Lv, C., & Wei, Y. (2016). Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion. Experimental and Therapeutic Medicine, 11, 1011-1016. https://doi.org/10.3892/etm.2016.2995
MLA
Feng, L., Liu, J., Liu, Y., Chen, J., Su, C., Lv, C., Wei, Y."Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion". Experimental and Therapeutic Medicine 11.3 (2016): 1011-1016.
Chicago
Feng, L., Liu, J., Liu, Y., Chen, J., Su, C., Lv, C., Wei, Y."Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion". Experimental and Therapeutic Medicine 11, no. 3 (2016): 1011-1016. https://doi.org/10.3892/etm.2016.2995
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