Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion

  • Authors:
    • Lei Feng
    • Jun Liu
    • Yunzhen Liu
    • Jian Chen
    • Chunhai Su
    • Chuanfeng Lv
    • Yuzhen Wei
  • View Affiliations

  • Published online on: January 14, 2016     https://doi.org/10.3892/etm.2016.2995
  • Pages: 1011-1016
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aims of the present study were to establish a model of embolic stroke in rabbits and to evaluate the efficacy and safety of intra‑arterially administered tirofiban combined with urokinase thrombolysis. The middle cerebral artery occlusion model (MCAO) of embolic stroke was established in New Zealand rabbits via an autologous clot. The model rabbits were allocated at random into four groups: Tirofiban group (T group), urokinase group (UK group), tirofiban and urokinase group (T + UK group) and the control group (C group). The recanalization rate, relative‑apparent diffusion coefficient (rADC) and neurological function deficit score (NFDS) values were compared among the four groups. The recanalization rate, rADC and NFDS values were improved in the T + UK group compared with the other groups. In summary, the intra‑arterial administration of tirofiban combined with urokinase thrombolysis was a more effective intervention in an MCAO model compared with intra‑arterial urokinase alone, and may promote reperfusion and reduce infarct volume.
View Figures
View References

Related Articles

Journal Cover

March-2016
Volume 11 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Feng L, Liu J, Liu Y, Chen J, Su C, Lv C and Wei Y: Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion. Exp Ther Med 11: 1011-1016, 2016
APA
Feng, L., Liu, J., Liu, Y., Chen, J., Su, C., Lv, C., & Wei, Y. (2016). Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion. Experimental and Therapeutic Medicine, 11, 1011-1016. https://doi.org/10.3892/etm.2016.2995
MLA
Feng, L., Liu, J., Liu, Y., Chen, J., Su, C., Lv, C., Wei, Y."Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion". Experimental and Therapeutic Medicine 11.3 (2016): 1011-1016.
Chicago
Feng, L., Liu, J., Liu, Y., Chen, J., Su, C., Lv, C., Wei, Y."Tirofiban combined with urokinase selective intra‑arterial thrombolysis for the treatment of middle cerebral artery occlusion". Experimental and Therapeutic Medicine 11, no. 3 (2016): 1011-1016. https://doi.org/10.3892/etm.2016.2995