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Article

Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma

  • Authors:
    • Guoliang Ma
    • Fengmei Zhang
    • Xueguang Dong
    • Xiaoli Wang
    • Yuguo Ren
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Laiwu People's Hospital, Laiwu, Shandong 271199, P.R. China, Department of Endocrinology, Laiwu People's Hospital, Laiwu, Shandong 271199, P.R. China
  • Pages: 951-956
    |
    Published online on: January 21, 2016
       https://doi.org/10.3892/etm.2016.3014
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Abstract

The present study aimed to determine the expression levels and biological functions of microRNA‑202 (miR‑202) in patients with esophageal squamous cell carcinoma (ESCC). A total of 60 patients with ESCC and 30 healthy individuals were enrolled and reverse transcription‑quantitative polymerase chain reaction was performed to measure the expression levels of miR‑202. In order to investigate the effects of miR‑202 expression levels on the proliferative, migratory and invasive abilities of ESCC cells, methylthiazolyl‑tetrazolium bromide proliferation, in vitro scratch and Transwell® chamber assays were performed. Expression levels of miR‑202 were significantly decreased in the peripheral blood of patients with ESCC, which is associated with the degree of cell differentiation and lymph node metastasis (P<0.05). Following miR‑202 transfection, cell proliferation was significantly inhibited (P<0.05). Cell migration and invasion was also significantly inhibited by miR‑202 transfection (P<0.05). The results of the present study demonstrated that the expression of miR‑202 inhibited the proliferation, migration and invasion of ESCC cells. Furthermore, low expression levels of miR‑202 were detected in the peripheral blood of patients with ESCC, which is associated with the development, invasion and metastasis of ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Ma G, Zhang F, Dong X, Wang X and Ren Y: Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma. Exp Ther Med 11: 951-956, 2016.
APA
Ma, G., Zhang, F., Dong, X., Wang, X., & Ren, Y. (2016). Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma. Experimental and Therapeutic Medicine, 11, 951-956. https://doi.org/10.3892/etm.2016.3014
MLA
Ma, G., Zhang, F., Dong, X., Wang, X., Ren, Y."Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma". Experimental and Therapeutic Medicine 11.3 (2016): 951-956.
Chicago
Ma, G., Zhang, F., Dong, X., Wang, X., Ren, Y."Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma". Experimental and Therapeutic Medicine 11, no. 3 (2016): 951-956. https://doi.org/10.3892/etm.2016.3014
Copy and paste a formatted citation
x
Spandidos Publications style
Ma G, Zhang F, Dong X, Wang X and Ren Y: Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma. Exp Ther Med 11: 951-956, 2016.
APA
Ma, G., Zhang, F., Dong, X., Wang, X., & Ren, Y. (2016). Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma. Experimental and Therapeutic Medicine, 11, 951-956. https://doi.org/10.3892/etm.2016.3014
MLA
Ma, G., Zhang, F., Dong, X., Wang, X., Ren, Y."Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma". Experimental and Therapeutic Medicine 11.3 (2016): 951-956.
Chicago
Ma, G., Zhang, F., Dong, X., Wang, X., Ren, Y."Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma". Experimental and Therapeutic Medicine 11, no. 3 (2016): 951-956. https://doi.org/10.3892/etm.2016.3014
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