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Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling

  • Authors:
    • Zhu Qin-Wei
    • Li Yong-Guang
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Weifang Hospital of Traditional Chinese Medicine, Weifang, Shandong 261041, P.R. China
    Copyright: © Qin-Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 978-984
    |
    Published online on: January 22, 2016
       https://doi.org/10.3892/etm.2016.3018
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Abstract

Berberine (BBR), an isoquinoline alkaloid originally isolated from the Chinese herb Coptis chinensis (Huanglian), exhibits anti‑inflammatory and immunosuppressive properties. Since myocardial ischemia/reperfusion (I/R) injury is associated with an excessive immune response, the current study was conducted to investigate the impact of BBR on myocardial I/R injury, a common disorder in clinical settings. Preconditioning of Sprague‑Dawley rats with BBR (100 mg/kg/day, by gavage) for 14 days prior to the induction of I/R significantly attenuated myocardial I/R injury as manifested by a reduction in the incidence of ventricular arrhythmia and the amelioration of myocardial histological changes. These effects were found to be associated with the suppression of the phosphoinositide 3‑kinase/AKT signaling pathway and the subsequent reduction of the expression of interleukin (IL)‑6, IL‑1β, and tumor necrosis factor‑α in the serum and myocardial tissue. These results indicate that BBR has the potential be an effective alternative therapy for the prevention and treatment of myocardial I/R injury in clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Qin-Wei Z and Yong-Guang L: Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling. Exp Ther Med 11: 978-984, 2016.
APA
Qin-Wei, Z., & Yong-Guang, L. (2016). Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling. Experimental and Therapeutic Medicine, 11, 978-984. https://doi.org/10.3892/etm.2016.3018
MLA
Qin-Wei, Z., Yong-Guang, L."Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling". Experimental and Therapeutic Medicine 11.3 (2016): 978-984.
Chicago
Qin-Wei, Z., Yong-Guang, L."Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling". Experimental and Therapeutic Medicine 11, no. 3 (2016): 978-984. https://doi.org/10.3892/etm.2016.3018
Copy and paste a formatted citation
x
Spandidos Publications style
Qin-Wei Z and Yong-Guang L: Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling. Exp Ther Med 11: 978-984, 2016.
APA
Qin-Wei, Z., & Yong-Guang, L. (2016). Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling. Experimental and Therapeutic Medicine, 11, 978-984. https://doi.org/10.3892/etm.2016.3018
MLA
Qin-Wei, Z., Yong-Guang, L."Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling". Experimental and Therapeutic Medicine 11.3 (2016): 978-984.
Chicago
Qin-Wei, Z., Yong-Guang, L."Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling". Experimental and Therapeutic Medicine 11, no. 3 (2016): 978-984. https://doi.org/10.3892/etm.2016.3018
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