Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling

Qin-Wei,Zhu; Yong-Guang,Li

doi:10.3892/etm.2016.3018

Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling

Authors:
- Zhu Qin-Wei
- Li Yong-Guang
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Affiliations: Department of Emergency, Weifang Hospital of Traditional Chinese Medicine, Weifang, Shandong 261041, P.R. China
Published online on: January 22, 2016 https://doi.org/10.3892/etm.2016.3018
Pages: 978-984
Copyright: © Qin-Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Berberine (BBR), an isoquinoline alkaloid originally isolated from the Chinese herb Coptis chinensis (Huanglian), exhibits anti‑inflammatory and immunosuppressive properties. Since myocardial ischemia/reperfusion (I/R) injury is associated with an excessive immune response, the current study was conducted to investigate the impact of BBR on myocardial I/R injury, a common disorder in clinical settings. Preconditioning of Sprague‑Dawley rats with BBR (100 mg/kg/day, by gavage) for 14 days prior to the induction of I/R significantly attenuated myocardial I/R injury as manifested by a reduction in the incidence of ventricular arrhythmia and the amelioration of myocardial histological changes. These effects were found to be associated with the suppression of the phosphoinositide 3‑kinase/AKT signaling pathway and the subsequent reduction of the expression of interleukin (IL)‑6, IL‑1β, and tumor necrosis factor‑α in the serum and myocardial tissue. These results indicate that BBR has the potential be an effective alternative therapy for the prevention and treatment of myocardial I/R injury in clinical practice.

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