Surgical resection of vasoactive intestinal peptideoma with hepatic metastasis aids symptom palliation: A case report

Zhang,Xiaomei; Zhou,Lingli; Liu,Ying; Li,Wei; Gao,Hongkai; Wang,Yunan; Yao,Baoting; Jiang,Daming; Hu,Peijun

doi:10.3892/etm.2016.3019

March-2016 Volume 11 Issue 3

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March-2016 Volume 11 Issue 3

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Case Report Open Access

Surgical resection of vasoactive intestinal peptideoma with hepatic metastasis aids symptom palliation: A case report

Authors:
- Xiaomei Zhang
- Lingli Zhou
- Ying Liu
- Wei Li
- Hongkai Gao
- Yunan Wang
- Baoting Yao
- Daming Jiang
- Peijun Hu
View Affiliations / Copyright

Affiliations: Department of Endocrinology, Peking University International Hospital, Beijing 102206, P.R. China, Department of Endocrinology, Peking University People's Hospital, Beijing 100044, P.R. China, Department of Internal Medicine, First Hospital, Dandong, Liaoning 118000, P.R. China, Department of Surgical Medicine, First Hospital, Dandong, Liaoning 118000, P.R. China, Department of Surgical Medicine, General Hospital of the Chinese People's Armed Police Forces, Beijing 100039, P.R. China, Department of Internal Medicine, Central Hospital, Dandong, Liaoning 118000, P.R. China, Department of Gastroenterology, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100026, P.R. China

Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 783-787
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Published online on: January 22, 2016

https://doi.org/10.3892/etm.2016.3019
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Abstract

Vasoactive intestinal peptideoma (VIPoma) is a rare pancreatic endocrine tumor associated with a well‑defined clinical syndrome characterized by watery diarrhea, hypokalemia and metabolic acidosis. In adults, VIPoma is most commonly found in the pancreas, with 80% of the tumors occurring in the body and tail and 20% occurring in the pancreatic head. VIPomas can represent a significant diagnostic challenge due to their nonspecific clinical presentation, which can result in the misdiagnosis of a VIPoma as another condition, such as laxative overdose or a carcinoid secreting tumor. Surgical clearance of the tumor is the first‑line treatment, even in cases with metastasis. The present study describes the case of a patient who presented with chronic watery diarrhea and hypokalemia due to a tumor in the pancreatic head, which was confirmed to contain immunoreactive vasoactive intestinal polypeptide via immunohistochemistry. A hepatic metastasis lesion was diagnosed following computed tomography. Stable control of symptoms was achieved after surgery and drug treatment. The study additionally reviews the clinical, histological, radiological and diagnostic features of the condition, as well as the therapeutic modalities that can be used to treat VIPoma in the pancreatic head with hepatic metastasis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Surgical resection of vasoactive intestinal peptideoma with hepatic metastasis aids symptom palliation: A case report

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