Lumican as a novel potential clinical indicator for acute aortic dissection: A comparative study, based on multi-slice computed tomography angiography

Gu,Guorong; Wan,Fang; Xue,Yuan; Cheng,Weizhong; Zheng,Haiyin; Zhao,Yun; Fan,Fan; Han,Yi; Tong,Chaoyang; Yao,Chenling

doi:10.3892/etm.2016.3020

Lumican as a novel potential clinical indicator for acute aortic dissection: A comparative study, based on multi-slice computed tomography angiography

Authors:
- Guorong Gu
- Fang Wan
- Yuan Xue
- Weizhong Cheng
- Haiyin Zheng
- Yun Zhao
- Fan Fan
- Yi Han
- Chaoyang Tong
- Chenling Yao
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Affiliations: Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Shanghai Medical Imaging Institute, Shanghai 200032, P.R. China, Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
Published online on: January 22, 2016 https://doi.org/10.3892/etm.2016.3020
Pages: 923-928

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Abstract

The aim of the present study was to investigate the association between serum lumican levels and acute aortic dissection (AAD) severity. A total of 82 patients with chest or back pain and 30 healthy volunteers were recruited. Among the patients, there were 70 cases of AAD and 12 cases of intramural hematoma (IMH). AAD severity was determined using multi‑slice computed tomography angiography (MSCTA). Serum was collected from the patients upon admission, and lumican levels were detected using an enzyme‑linked immunosorbent assay. In addition, correlation analyses were conducted between lumican levels and AAD severity by designing a ‘SCORE X, RANGE Y’ system to measure the number of affected vital arteries and vertical range of false lumen, based on the MSCTA. Lumican levels differed significantly among the AAD patients (2.32±4.29 ng/ml), IMH patients (0.72±0.32 ng/ml) and healthy volunteers (0.85±0.53 ng/ml; P=0.003). In the AAD patients presenting within 12‑72 h of symptom onset, the Spearman's rho correlation coefficient between lumican and SCORE or RANGE was 0.373 (P=0.046) and 0.468 (P=0.010), respectively. The present results suggest that lumican may be a potential marker for aiding the diagnosis and screening for AAD, and may be used to predict the severity of AAD.

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