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Article

Lumican as a novel potential clinical indicator for acute aortic dissection: A comparative study, based on multi-slice computed tomography angiography

  • Authors:
    • Guorong Gu
    • Fang Wan
    • Yuan Xue
    • Weizhong Cheng
    • Haiyin Zheng
    • Yun Zhao
    • Fan Fan
    • Yi Han
    • Chaoyang Tong
    • Chenling Yao
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Shanghai Medical Imaging Institute, Shanghai 200032, P.R. China, Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
  • Pages: 923-928
    |
    Published online on: January 22, 2016
       https://doi.org/10.3892/etm.2016.3020
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Abstract

The aim of the present study was to investigate the association between serum lumican levels and acute aortic dissection (AAD) severity. A total of 82 patients with chest or back pain and 30 healthy volunteers were recruited. Among the patients, there were 70 cases of AAD and 12 cases of intramural hematoma (IMH). AAD severity was determined using multi‑slice computed tomography angiography (MSCTA). Serum was collected from the patients upon admission, and lumican levels were detected using an enzyme‑linked immunosorbent assay. In addition, correlation analyses were conducted between lumican levels and AAD severity by designing a ‘SCORE X, RANGE Y’ system to measure the number of affected vital arteries and vertical range of false lumen, based on the MSCTA. Lumican levels differed significantly among the AAD patients (2.32±4.29 ng/ml), IMH patients (0.72±0.32 ng/ml) and healthy volunteers (0.85±0.53 ng/ml; P=0.003). In the AAD patients presenting within 12‑72 h of symptom onset, the Spearman's rho correlation coefficient between lumican and SCORE or RANGE was 0.373 (P=0.046) and 0.468 (P=0.010), respectively. The present results suggest that lumican may be a potential marker for aiding the diagnosis and screening for AAD, and may be used to predict the severity of AAD.
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1 

Mészáros I, Mórocz J, Szlávi J, Schmidt J, Tornóci L, Nagy L and Szép L: Epidemiology and clinicopathology of aortic dissection. Chest. 117:1271–1278. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Hagan PG, Nienaber CA, Isselbacher EM, Bruckman D, Karavite DJ, Russman PL, Evangelista A, Fattori R, Suzuki T, Oh JK, et al: The international registry of acute aortic dissection (IRAD): New insights into an old disease. JAMA. 283:897–903. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Elefteriades JA, Barrett PW and Kopf GS: Litigation in nontraumatic aortic diseases-a tempest in the malpractice maelstrom. Cardiology. 109:263–272. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Hayter RG, Rhea JT, Small A, Tafazoli FS and Novelline RA: Suspected aortic dissection and other aortic disorders: Multi-detector row CT in 373 cases in the emergency setting. Radiology. 238:841–852. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Stein PD, Fowler SE, Goodman LR, Gottschalk A, Hales CA, Hull RD, Leeper KV Jr, Popovich J Jr, Quinn DA, Sos TA, et al: Multidetector computed tomography for acute pulmonary embolism. N Engl J Med. 354:2317–2327. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Macura KJ, Szarf G, Fishman EK and Bluemke DA: Role of computed tomography and magnetic resonance imaging in assessment of acute aortic syndromes. Semin Ultrasound CT MR. 24:232–254. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Iezzi R and Cotroneo AR: Endovascular repair of abdominal aortic aneurysms: CTA evaluation of contraindications. Abdom Imaging. 31:722–731. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Rousseau H, Chabbert V, Maracher MA, El Aassar O, Auriol J, Massabuau P and Moreno R: The importance of imaging assessment before endovascular repair of thoracic aorta. Eur J Vasc Endovasc Surg. 38:408–421. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Suzuki T, Distante A and Eagle K: Biomarker-assisted diagnosis of acute aortic dissection: How far we have come and what to expect. Curr Opin Cardiol. 25:541–545. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Shinohara T, Suzuki K, Okada M, Shigai M, Shimizu M, Maehara T and Ohsuzu F: Soluble elastin fragments in serum are elevated in acute aortic dissection. J Cardiol. 43:96–97. 2004.(In Japanese). PubMed/NCBI

11 

Gu G, Cheng W, Yao C, Yin J, Tong C, Rao A, Yen L, Ku M and Rao J: Quantitative proteomics analysis by isobaric tags for relative and absolute quantitation identified lumican as a potential marker for acute aortic dissection. J Biomed Biotechnol. 2011:9207632011. View Article : Google Scholar : PubMed/NCBI

12 

Takayama R, Ishiwata T, Ansai S, Yamamoto T, Matsuda Y, Naito Z and Kawana S: Lumican as a novel marker for differential diagnosis of Bowen disease and actinic keratosis. Am J Dermatopathol. 35:827–832. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Engebretsen KV, Lunde IG, Strand ME, Waehre A, Sjaastad I, Marstein HS, Skrbic B, Dahl CP, Askevold ET, Christensen G, et al: Lumican is increased in experimental and clinical heart failure and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli. FEBS J. 280:2382–2398. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Yang ZX, Lu CY, Yang YL, Dou KF and Tao KS: Lumican expression in pancreatic ductal adenocarcinoma. Hepatogastroenterology. 60:349–353. 2013.PubMed/NCBI

15 

Nikitovic D, Papoutsidakis A, Karamanos NK and Tzanakakis GN: Lumican affects tumor cell functions, tumor-ECM interactions, angiogenesis and inflammatory response. Matrix Biol. 35:206–214. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Erbel R, Alfonso F, Boileau C, Dirsch O, Eber B, Haverich A, Rakowski H, Struyven J, Radegran K, Sechtem U, et al: Diagnosis and management of aortic dissection. Eur Heart J. 22:1642–1681. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Sheikh AS, Ali K and Mazhar S: Acute aortic syndrome. Circulation. 128:1122–1127. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Castañer E, Andreu M, Gallardo X, Mata JM, Cabezuelo MA and Pallardó Y: CT in nontraumatic acute thoracic aortic disease: Typical and atypical features and complications. Radiographics. 23:S93–S110. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Nazerian P, Morello F, Vanni S, Bono A, Castelli M, Forno D, Gigli C, Soardo F, Carbone F, Lupia E and Grifoni S: Combined use of aortic dissection detection risk score and D-dimer in the diagnostic workup of suspected acute aortic dissection. Int J Cardiol. 175:78–82. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Qin H, Ishiwata T and Asano G: Effects of the extracellular matrix on lumican expression in rat aortic smooth muscle cells in vitro. J Pathol. 195:604–608. 2011. View Article : Google Scholar

21 

Naito Z: Role of small leucine-rich proteoglycan (SLRP) family in pathological lesions and cancer cell growth. J Nippon Med Sch. 72:137–145. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gu G, Wan F, Xue Y, Cheng W, Zheng H, Zhao Y, Fan F, Han Y, Tong C, Yao C, Yao C, et al: Lumican as a novel potential clinical indicator for acute aortic dissection: A comparative study, based on multi-slice computed tomography angiography. Exp Ther Med 11: 923-928, 2016.
APA
Gu, G., Wan, F., Xue, Y., Cheng, W., Zheng, H., Zhao, Y. ... Yao, C. (2016). Lumican as a novel potential clinical indicator for acute aortic dissection: A comparative study, based on multi-slice computed tomography angiography. Experimental and Therapeutic Medicine, 11, 923-928. https://doi.org/10.3892/etm.2016.3020
MLA
Gu, G., Wan, F., Xue, Y., Cheng, W., Zheng, H., Zhao, Y., Fan, F., Han, Y., Tong, C., Yao, C."Lumican as a novel potential clinical indicator for acute aortic dissection: A comparative study, based on multi-slice computed tomography angiography". Experimental and Therapeutic Medicine 11.3 (2016): 923-928.
Chicago
Gu, G., Wan, F., Xue, Y., Cheng, W., Zheng, H., Zhao, Y., Fan, F., Han, Y., Tong, C., Yao, C."Lumican as a novel potential clinical indicator for acute aortic dissection: A comparative study, based on multi-slice computed tomography angiography". Experimental and Therapeutic Medicine 11, no. 3 (2016): 923-928. https://doi.org/10.3892/etm.2016.3020
Copy and paste a formatted citation
x
Spandidos Publications style
Gu G, Wan F, Xue Y, Cheng W, Zheng H, Zhao Y, Fan F, Han Y, Tong C, Yao C, Yao C, et al: Lumican as a novel potential clinical indicator for acute aortic dissection: A comparative study, based on multi-slice computed tomography angiography. Exp Ther Med 11: 923-928, 2016.
APA
Gu, G., Wan, F., Xue, Y., Cheng, W., Zheng, H., Zhao, Y. ... Yao, C. (2016). Lumican as a novel potential clinical indicator for acute aortic dissection: A comparative study, based on multi-slice computed tomography angiography. Experimental and Therapeutic Medicine, 11, 923-928. https://doi.org/10.3892/etm.2016.3020
MLA
Gu, G., Wan, F., Xue, Y., Cheng, W., Zheng, H., Zhao, Y., Fan, F., Han, Y., Tong, C., Yao, C."Lumican as a novel potential clinical indicator for acute aortic dissection: A comparative study, based on multi-slice computed tomography angiography". Experimental and Therapeutic Medicine 11.3 (2016): 923-928.
Chicago
Gu, G., Wan, F., Xue, Y., Cheng, W., Zheng, H., Zhao, Y., Fan, F., Han, Y., Tong, C., Yao, C."Lumican as a novel potential clinical indicator for acute aortic dissection: A comparative study, based on multi-slice computed tomography angiography". Experimental and Therapeutic Medicine 11, no. 3 (2016): 923-928. https://doi.org/10.3892/etm.2016.3020
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