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Role of the PTEN/PI3K/VEGF pathway in the development of Kawasaki disease

  • Authors:
    • Xinjiang An
    • Haitao Lv
    • Jing Tian
    • Xiuhua He
    • Nan Ling
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China, Department of Cardiology, Suzhou Children's Hospital, Suzhou, Jiangsu 215003, P.R. China
    Copyright: © An et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1318-1322
    |
    Published online on: January 27, 2016
       https://doi.org/10.3892/etm.2016.3026
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Abstract

Kawasaki disease (KD) is a disease of unknown etio­logy and the leading cause of childhood acquired heart disease. In this study, the significance of the phosphatase and tensin homolog (PTEN)/phosphoinositide 3‑kinase (PI3K)/vascular endothelial growth factor (VEGF) pathway in the development of KD was investigated in a rabbit model. Rabbits were divided into the control group, which received saline injection, and the experimental group, which was treated with bovine serum albumin to induce arthritis and KD. After 1, 7 and 30 days the animals were sacrificed, and the white blood cell count, serum VEGF, and serum creatine kinase (CK) levels were measured. The coronary artery was examined histologically as well as immunohistochemically for PTEN and PI3K. After the induction of arthritis, coronary artery of the rabbits showed endothelial cell swelling, osteoporosis, necrosis and inflammatory cell infiltration. PTEN expression in these rabbits increased with the increasing number of modeling days. The expression of PI3K showed a decreasing trend. The number of white blood cells in rabbits after KD modeling were significantly higher than those in the controls. One day and 7 days after modeling the serum VEGF level in KD rabbits was significantly higher than that in the control group after 1 and 7 days followed by a decrease by 30 days. There was no significant change in serum CK on the day after the modeling, and the serum CK level was significantly higher after 7 and 30 days. In conclusion, the expression of PTEN/PI3K was altered at different stages of KD. PTEN expression gradually increased with the disease progression, while the expression of PI3K gradually decreased. Serum markers indicated that the PTEN/PI3K/VEGF signaling pathway is important in the vascular injury in KD.
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1 

Patel RM and Shulman ST: Kawasaki disease: a comprehensive review of treatment options. J Clin Pharm Ther. 40:620–625. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Tanaka N: Kawasaki disease (acute febrile infantile muco-cutaneous lymph node syndrome) in Japan; relationship with infantile periarteritis nodosa. Pathol Microbiol (Basel). 43(2-O): 204–218. 1975.PubMed/NCBI

3 

Fujiwara H and Hamashima Y: Pathology of the heart in Kawasaki disease. Pediatrics. 61:100–107. 1978.PubMed/NCBI

4 

Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, Shulman ST, Bolger AF, Ferrieri P, Baltimore RS, et al: Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association: Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics. 114:1708–1733. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Dajani AS, Taubert KA, Gerber MA, Shulman ST, Ferrieri P, Freed M, Takahashi M, Bierman FZ, Karchmer AW and Wilson W: Diagnosis and therapy of Kawasaki disease in children. Circulation. 87:1776–1780. 1993. View Article : Google Scholar : PubMed/NCBI

6 

Matsubara K and Fukaya T: The role of superantigens of group A streptococcus and staphylococcus aureus in Kawasaki disease. Curr Opin Infect Dis. 20:298–303. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Ichiyama T, Yoshitomi T, Nishikawa M, Fujiwara M, Matsubara T, Hayashi T and Furukawa S: NF-kappaB activation in peripheral blood monocytes/macrophages and T cells during acute Kawasaki disease. Clin Immunol. 99:373–377. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Yu X, Hirono KI, Ichida F, Uese K, Rui C, Watanabe S, Watanabe K, Hashimoto I, Kumada T, Okada E, et al: Enhanced iNOS expression in leukocytes and circulating endothelial cells is associated with the progression of coronary artery lesions in acute Kawasaki disease. Pediatr Res. 55:688–694. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Kariyazono H, Ohno T, Khajoee V, Ihara K, Kusuhara K, Kinukawa N, Mizuno Y and Hara T: Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease. Pediatr Res. 56:953–959. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Peng Q, Zhou TF, Chen CH, Hua YM, Liu HM, Hong H, Zhang LY and Wu Q: Clinical value of serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 for the prediction and early diagnosis of coronary artery lesion in patients with Kawasaki disease. Zhonghua Er Ke Za Zhi. 43:676–680. 2005.(In Chinese). PubMed/NCBI

11 

Onouchi Z, Ikuta K, Nagamatsu K, Tamiya H, Sakakibara Y and Ando M: Coronary artery aneurysms develop in weanling rabbits with serum sickness but not in mature rabbits. An experimental model for Kawasaki disease in humans. Angiology. 46:679–687. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Shulman ST and Rowley AH: Kawasaki disease: insights into pathogenesis and approaches to treatment[J]. Nat Rev Rheumatol. 11:475–482. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Yamei H, Zaifang J and Futang Z: Pract Paidonosology. 2012.16472012.

14 

Qi Z, Limin X and Shuxia D: Changes of serum VEGF and NO levels in children with Kawasaki disease and its clinical significance. J Med Res. 36:100–102. 2007.

15 

Dey N, Crosswell HE, De P, Parsons R, Peng Q, Su JD and Durden DL: The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. Cancer Res. 68:1862–1871. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Jiang BH, Zheng JZ, Aoki M and Vogt PK: Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci USA. 97:1749–1753. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Garlich JR, De P, Dey N, Su JD, Peng X, Miller A, Murali R, Lu Y, Mills GB, Kundra V, et al: A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res. 68:206–215. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Alvarez Y, Astudillo O, Jensen L, Reynolds AL, Waghorne N, Brazil DP, Cao Y, O'Connor JJ and Kennedy BN: Selective inhibition of retinal angiogenesis by targeting PI3 kinase. PLoS One. 4:e78672009. View Article : Google Scholar : PubMed/NCBI

19 

Carracedo A and Pandolfi PP: The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene. 27:5527–5541. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Carnero A, Blanco-Aparicio C, Renner O, Link W and Leal JF: The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets. 8:187–198. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Rodríguez-Escudero I, Roelants FM, Thorner J, Nombela C, Molina M and Cid VJ: Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast. Biochem J. 390:613–623. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
An X, Lv H, Tian J, He X and Ling N: Role of the PTEN/PI3K/VEGF pathway in the development of Kawasaki disease. Exp Ther Med 11: 1318-1322, 2016.
APA
An, X., Lv, H., Tian, J., He, X., & Ling, N. (2016). Role of the PTEN/PI3K/VEGF pathway in the development of Kawasaki disease. Experimental and Therapeutic Medicine, 11, 1318-1322. https://doi.org/10.3892/etm.2016.3026
MLA
An, X., Lv, H., Tian, J., He, X., Ling, N."Role of the PTEN/PI3K/VEGF pathway in the development of Kawasaki disease". Experimental and Therapeutic Medicine 11.4 (2016): 1318-1322.
Chicago
An, X., Lv, H., Tian, J., He, X., Ling, N."Role of the PTEN/PI3K/VEGF pathway in the development of Kawasaki disease". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1318-1322. https://doi.org/10.3892/etm.2016.3026
Copy and paste a formatted citation
x
Spandidos Publications style
An X, Lv H, Tian J, He X and Ling N: Role of the PTEN/PI3K/VEGF pathway in the development of Kawasaki disease. Exp Ther Med 11: 1318-1322, 2016.
APA
An, X., Lv, H., Tian, J., He, X., & Ling, N. (2016). Role of the PTEN/PI3K/VEGF pathway in the development of Kawasaki disease. Experimental and Therapeutic Medicine, 11, 1318-1322. https://doi.org/10.3892/etm.2016.3026
MLA
An, X., Lv, H., Tian, J., He, X., Ling, N."Role of the PTEN/PI3K/VEGF pathway in the development of Kawasaki disease". Experimental and Therapeutic Medicine 11.4 (2016): 1318-1322.
Chicago
An, X., Lv, H., Tian, J., He, X., Ling, N."Role of the PTEN/PI3K/VEGF pathway in the development of Kawasaki disease". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1318-1322. https://doi.org/10.3892/etm.2016.3026
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