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Pathophysiology of valvular heart disease (Review)

  • Authors:
    • Yi Zeng
    • Rongrong Sun
    • Xianchi Li
    • Min Liu
    • Shuang Chen
    • Peiying Zhang
  • View Affiliations / Copyright

    Affiliations: Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China, Department of Cardiology, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, Jiangsu 221009, P.R. China, Department of Cardiology, Xuzhou Clinical School of Xuzhou Medical College, Xuzhou, Jiangsu 221009, P.R. China
    Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1184-1188
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    Published online on: February 5, 2016
       https://doi.org/10.3892/etm.2016.3048
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Abstract

Valvular heart disease (VHD) is caused by either damage or defect in one of the four heart valves, aortic, mitral, tricuspid or pulmonary. Defects in these valves can be congenital or acquired. Age, gender, tobacco use, hypercholesterolemia, hypertension, and type II diabetes contribute to the risk of disease. VHD is an escalating health issue with a prevalence of 2.5% in the United States alone. Considering the likely increase of the aging population worldwide, the incidence of acquired VHD is expected to increase. Technological advances are instrumental in identifying congenital heart defects in infants, thereby adding to the growing VHD population. Almost one‑third of elderly individuals have echocardiographic or radiological evidence of calcific aortic valve (CAV) sclerosis, an early and subclinical form of CAV disease (CAVD). Of individuals ages >60, ~2% suffer from disease progression to its most severe form, calcific aortic stenosis. Surgical intervention is therefore required in these patients as no effective pharmacotherapies exist. Valvular calcium load and valve biomineralization are orchestrated by the concerted action of diverse cell‑dependent mechanisms. Signaling pathways important in skeletal morphogenesis are also involved in the regulation of cardiac valve morphogenesis, CAVD and the pathobiology of cardiovascular calcification. CAVD usually occurs without any obvious symptoms in early stages over a long period of time and symptoms are identified at advanced stages of the disease, leading to a high rate of mortality. Aortic valve replacement is the only primary treatment of choice. Biomarkers such as asymmetric dimethylarginine, fetuin‑A, calcium phosphate product, natriuretic peptides and osteopontin have been useful in improving outcomes among various disease states. This review, highlights the current understanding of the biology of VHD, with particular reference to molecular and cellular aspects of its regulation. Current clinical questions and the development of new strategies to treat various forms of VHD medically were addressed.
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View References

1 

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, et al: American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Heart disease and stroke statistics-2013 update: a report from the American Heart Association. Circulation. 127:e6–e245. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, et al: Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. Circulation. 124:1783–1791. 2011. View Article : Google Scholar : PubMed/NCBI

3 

d'Arcy JL, Prendergast BD, Chambers JB, Ray SG and Bridgewater B: Valvular heart disease: The next cardiac epidemic. Heart. 97:91–93. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Le Gloan L, Mercier LA, Dore A, Marcotte F, Ibrahim R, Mongeon FP, Asgar A, Miro J, Poirier N and Khairy P: Recent advances in adult congenital heart disease. Circ J. 75:2287–2295. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Katz R, Wong ND, Kronmal R, Takasu J, Shavelle DM, Probstfield JL, Bertoni AG, Budoff MJ and O'Brien KD: Features of the metabolic syndrome and diabetes mellitus as predictors of aortic valve calcification in the Multi-Ethnic Study of Atherosclerosis. Circulation. 113:2113–2119. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Itagaki S, Adams DH and Anyanwu AC: Triggers for surgical referral in degenerative mitral valve regurgitation. Circ J. 77:28–34. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Maeda K, Kuratani T, Mizote I, Shimamura K, Takeda Y, Torikai K, Nakatani S, Nanto S and Sawa Y: Early experiences of transcatheter aortic valve replacement in Japan. Circ J. 77:359–362. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Beckmann E, Grau JB, Sainger R, Poggio P and Ferrari G: Insights into the use of biomarkers in calcific aortic valve disease. J Heart Valve Dis. 19:441–452. 2010.PubMed/NCBI

9 

Nightingale AK and Horowitz JD: Aortic sclerosis: Not an innocent murmur but a marker of increased cardiovascular risk. Heart. 91:1389–1393. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Tao G, Kotick JD and Lincoln J: Heart valve development, maintenance, and disease: The role of endothelial cells. Curr Top Dev Biol. 100:203–232. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Hinton RB Jr, Lincoln J, Deutsch GH, Osinska H, Manning PB, Benson DW and Yutzey KE: Extracellular matrix remodeling and organization in developing and diseased aortic valves. Circ Res. 98:1431–1438. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Mohler ER III, Gannon F, Reynolds C, Zimmerman R, Keane MG and Kaplan FS: Bone formation and inflammation in cardiac valves. Circulation. 103:1522–1528. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Boström KI, Jumabay M, Matveyenko A, Nicholas SB and Yao Y: Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Circ Res. 108:446–457. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Srivatsa SS, Harrity PJ, Maercklein PB, Kleppe L, Veinot J, Edwards WD, Johnson CM and Fitzpatrick LA: Increased cellular expression of matrix proteins that regulate mineralization is associated with calcification of native human and porcine xenograft bioprosthetic heart valves. J Clin Invest. 99:996–1009. 1997. View Article : Google Scholar : PubMed/NCBI

15 

Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA and Parker KK: Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proc Natl Acad Sci USA. 108:19943–19948. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Winchester R, Wiesendanger M, O'Brien W, Zhang HZ, Maurer MS, Gillam LD, Schwartz A, Marboe C and Stewart AS: Circulating activated and effector memory T cells are associated with calcification and clonal expansions in bicuspid and tricuspid valves of calcific aortic stenosis. J Immunol. 187:1006–1014. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Otto CM, Kuusisto J, Reichenbach DD, Gown AM and O'Brien KD: Characterization of the early lesion of ‘degenerative’ valvular aortic stenosis. Histological and immunohistochemical studies. Circulation. 90:844–853. 1994. View Article : Google Scholar : PubMed/NCBI

18 

Laird DF, Mucalo MR and Yokogawa Y: Growth of calcium hydroxyapatite (Ca-HAp) on cholesterol and cholestanol crystals from a simulated body fluid: A possible insight into the pathological calcifications associated with atherosclerosis. J Colloid Interface Sci. 295:348–363. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Schoen FJ and Levy RJ: Founder's Award, 25th Annual Meeting of the Society for Biomaterials, perspectives. Providence, RI, April 28-May 2, 1999. Tissue heart valves: Current challenges and future research perspectives. J Biomed Mater Res. 47:439–465. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Rajamannan NM, Subramaniam M, Rickard D, Stock SR, Donovan J, Springett M, Orszulak T, Fullerton DA, Tajik AJ, Bonow RO, et al: Human aortic valve calcification is associated with an osteoblast phenotype. Circulation. 107:2181–2184. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Kapustin AN, Davies JD, Reynolds JL, McNair R, Jones GT, Sidibe A, Schurgers LJ, Skepper JN, Proudfoot D, Mayr M, et al: Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization. Circ Res. 109:e1–e12. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Jahnen-Dechent W, Heiss A, Schäfer C and Ketteler M: Fetuin-A regulation of calcified matrix metabolism. Circ Res. 108:1494–1509. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Egan KP, Kim JH, Mohler ER III and Pignolo RJ: Role for circulating osteogenic precursor cells in aortic valvular disease. Arterioscler Thromb Vasc Biol. 31:2965–2971. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Fadini GP, Albiero M, Menegazzo L, Boscaro E, de Kreutzenberg Vigili S, Agostini C, Cabrelle A, Binotto G, Rattazzi M, Bertacco E, et al: Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes. Circ Res. 108:1112–1121. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Wallby L, Janerot-Sjöberg B, Steffensen T and Broqvist M: T lymphocyte infiltration in non-rheumatic aortic stenosis: A comparative descriptive study between tricuspid and bicuspid aortic valves. Heart. 88:348–351. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Towler DA: Molecular and cellular aspects of calcific aortic valve disease. Circ Res. 113:198–208. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, et al: CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 11:155–161. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Miller JD, Chu Y, Brooks RM, Richenbacher WE, Peña-Silva R and Heistad DD: Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans. J Am Coll Cardiol. 52:843–850. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Lincoln J and Garg V: Etiology of valvular heart disease-genetic and developmental origins. Circ J. 78:1801–1807. 2014. View Article : Google Scholar : PubMed/NCBI

30 

McBride KL and Garg V: Heredity of bicuspid aortic valve: Is family screening indicated? Heart. 97:1193–1195. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Hofmann JJ, Briot A, Enciso J, Zovein AC, Ren S, Zhang ZW, Radtke F, Simons M, Wang Y and Iruela-Arispe ML: Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development. 139:4449–4460. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Foffa I, Ait Alì L, Panesi P, Mariani M, Festa P, Botto N, Vecoli C and Andreassi MG: Sequencing of NOTCH1, GATA5, TGFBR1 and TGFBR2 genes in familial cases of bicuspid aortic valve. BMC Med Genet. 14:442013. View Article : Google Scholar : PubMed/NCBI

33 

Nus M, MacGrogan D, Martínez-Poveda B, Benito Y, Casanova JC, Fernández-Avilés F, Bermejo J and de la Pompa JL: Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL. Arterioscler Thromb Vasc Biol. 31:1580–1588. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Freed LA, Levy D, Levine RA, Larson MG, Evans JC, Fuller DL, Lehman B and Benjamin EJ: Prevalence and clinical outcome of mitral-valve prolapse. N Engl J Med. 341:1–7. 1999. View Article : Google Scholar : PubMed/NCBI

35 

Lincoln J and Garg V: Etiology of valvular heart disease-genetic and developmental origins. Circ J. 78:1801–1807. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Armstrong EJ and Bischoff J: Heart valve development: Endothelial cell signaling and differentiation. Circ Res. 95:459–470. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Thanassoulis G, Campbell CY, Owens DS, Smith JG, Smith AV, Peloso GM, Kerr KF, Pechlivanis S, Budoff MJ, Harris TB, et al: CHARGE Extracoronary Calcium Working Group: Genetic associations with valvular calcification and aortic stenosis. N Engl J Med. 368:503–512. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Balmer C, Beghetti M, Fasnacht M, Friedli B and Arbenz U: Balloon aortic valvoplasty in paediatric patients: Progressive aortic regurgitation is common. Heart. 90:77–81. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Webb JG, Chandavimol M, Thompson CR, Ricci DR, Carere RG, Munt BI, Buller CE, Pasupati S and Lichtenstein S: Percutaneous aortic valve implantation retrograde from the femoral artery. Circulation. 113:842–850. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Vallance P, Leone A, Calver A, Collier J and Moncada S: Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet. 339:572–575. 1992. View Article : Google Scholar : PubMed/NCBI

41 

Koos R, Brandenburg V, Mahnken AH, Mühlenbruch G, Stanzel S, Günther RW, Floege J, Jahnen-Dechent W, Kelm M and Kühl HP: Association of fetuin-A levels with the progression of aortic valve calcification in non-dialyzed patients. Eur Heart J. 30:2054–2061. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Yu PJ, Skolnick A, Ferrari G, Heretis K, Mignatti P, Pintucci G, Rosenzweig B, Diaz-Cartelle J, Kronzon I, Perk G, et al: Correlation between plasma osteopontin levels and aortic valve calcification: Potential insights into the pathogenesis of aortic valve calcification and stenosis. J Thorac Cardiovasc Surg. 138:196–199. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zeng Y, Sun R, Li X, Liu M, Chen S and Zhang P: Pathophysiology of valvular heart disease (Review). Exp Ther Med 11: 1184-1188, 2016.
APA
Zeng, Y., Sun, R., Li, X., Liu, M., Chen, S., & Zhang, P. (2016). Pathophysiology of valvular heart disease (Review). Experimental and Therapeutic Medicine, 11, 1184-1188. https://doi.org/10.3892/etm.2016.3048
MLA
Zeng, Y., Sun, R., Li, X., Liu, M., Chen, S., Zhang, P."Pathophysiology of valvular heart disease (Review)". Experimental and Therapeutic Medicine 11.4 (2016): 1184-1188.
Chicago
Zeng, Y., Sun, R., Li, X., Liu, M., Chen, S., Zhang, P."Pathophysiology of valvular heart disease (Review)". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1184-1188. https://doi.org/10.3892/etm.2016.3048
Copy and paste a formatted citation
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Spandidos Publications style
Zeng Y, Sun R, Li X, Liu M, Chen S and Zhang P: Pathophysiology of valvular heart disease (Review). Exp Ther Med 11: 1184-1188, 2016.
APA
Zeng, Y., Sun, R., Li, X., Liu, M., Chen, S., & Zhang, P. (2016). Pathophysiology of valvular heart disease (Review). Experimental and Therapeutic Medicine, 11, 1184-1188. https://doi.org/10.3892/etm.2016.3048
MLA
Zeng, Y., Sun, R., Li, X., Liu, M., Chen, S., Zhang, P."Pathophysiology of valvular heart disease (Review)". Experimental and Therapeutic Medicine 11.4 (2016): 1184-1188.
Chicago
Zeng, Y., Sun, R., Li, X., Liu, M., Chen, S., Zhang, P."Pathophysiology of valvular heart disease (Review)". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1184-1188. https://doi.org/10.3892/etm.2016.3048
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