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Article

Predicting relapse of Graves' disease following treatment with antithyroid drugs

  • Authors:
    • Lin Liu
    • Hongwen Lu
    • Yang Liu
    • Changshan Liu
    • Chu Xun
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Endocrinology, Kailuan General Hospital, Tangshan, Hebei 063000, P.R. China, Department of Genetics, Shanghai‑MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center, Shanghai Academy of Science and Technology, Shanghai 201203, P.R. China
  • Pages: 1453-1458
    |
    Published online on: February 9, 2016
       https://doi.org/10.3892/etm.2016.3058
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Abstract

The aim of the present study was to monitor long term antithyroid drug treatments and to identify prognostic factors for Graves' disease (GD). A total of 306 patients with GD who were referred to the Endocrinology Clinic at Weifang People's Hospital (Weifang, China) between August 2005 and June 2009 and treated with methimazole were included in the present study. Following treatment, patients were divided into non‑remission, including recurrence and constant treatment subgroups, and remission groups. Various prognosis factors were analyzed and compared, including: Patient age, gender, size of thyroid prior to and following treatment, thyroid hormone levels, disease relapse, hypothyroidism and drug side‑effects, and states of thyrotropin suppression were observed at 3, 6 and 12 months post‑treatment. Sixty‑five patients (21.2%) were male, and 241 patients (78.8%) were female. The mean age was 42±11 years, and the follow‑up was 31.5±6.8 months. Following long‑term treatment, 141 patients (46%) demonstrated remission of hyperthyroidism with a mean duration of 18.7±1.9 months. The average age at diagnosis was 45.6±10.3 years in the remission group, as compared with 36.4±8.8 years in the non‑remission group (t=3.152; P=0.002). Free thyroxine (FT)3 levels were demonstrated to be 25.2±8.9 and 18.7±9.4 pmol/l in the non‑remission and remission groups, respectively (t=3.326, P=0.001). The FT3/FT4 ratio and thyrotrophin receptor antibody (TRAb) levels were both significantly higher in the non‑remission group (t=3.331, 3.389, P=0.001), as compared with the remission group. Logistic regression analysis demonstrated that elevated thyroid size, FT3/FT4 ratio and TRAb at diagnosis were associated with poor outcomes. The ratio of continued thyrotropin suppression in the recurrent subgroup was significantly increased, as compared with the remission group (P=0.001), as thyroid function reached euthyroid state at 3, 6 and 12 months post‑treatment. Patients with GD exhibiting large thyroids, high pre‑mediation TRAb levels and elevated FT3/FT4 ratios responded less markedly to antithyroid drug treatments, as compared with patients not exhibiting these prognostic factors. Furthermore, patients with large thyroids, post-medication ophthalmopathy and continued thyrotropin suppression demonstrated higher rates of recurrence.
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1 

Jameson JL and Weetman AP: Disorders of thyroid gland. Harrison's Principles of Internal Medicine. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL and Jameson JL: (16th). McGraw-Hill. (New York, NY). 2104–2127. 2005.

2 

Wille T, Müller B, Noth D, Bürgi U and Diem P: Long-term follow up after antithyroid drug treatment in Graves' disease. Praxis (Bern). 1994:1121–1127. 2006.(In German). View Article : Google Scholar

3 

Abraham P, Avenell A, Park CM, Watson WA and Bevan JS: A systematic review of drug therapy for Graves' hyperthyroidism. Eur J Endocrinol. 153:489–498. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Weetman AP: Graves' disease. N Engl J Med. 343:1236–1248. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Bagnasco M, Venuti D, Caria M, Pizzamo G, Ferrini O and Canonica GW: Methimazole, γ-”Interferon and Graves' Disease. Thyroid Autoimmunity. Pinchera A, Ingbar SH, McKenzie JM and Fenzi GF: (1st). Springer US. (New York, NY). 445–447. 1987. View Article : Google Scholar

6 

Bagnasco M, Venuti D, Ciprandi G, Pesce G, Paolieri F and Canonica GW: The effect of methimazole on the immune system is unlikely to operate directly on T lymphocytes. J Endocrinol Invest. 13:493–499. 1990. View Article : Google Scholar : PubMed/NCBI

7 

Sato H, Minagawa M, Sasaki N, Sugihara S, Kazukawa I, Minamitani K, Wataki K, Konda S, Inomata H, Sanayama K and Kohno Y: Comparison of methimazole and propylthiouracil in the management of children and adolescents with Graves' disease: Efficacy and adverse reactions during initial treatment and long-term outcome. J Pediatr Endocrinol Metab. 24:257–263. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Trepanier LA: Medical management of hyperthyroidism. Clin Tech Small Anim Pract. 21:22–28. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Benker G, Vitti P, Kahaly G, Raue F, Tegler L, Hirche H and Reinwein D: The European Multicenter Study Group: Response to methimazole in Graves' disease. Clin Endocrinol (Oxf). 43:257–263. 1995. View Article : Google Scholar : PubMed/NCBI

10 

Chinese Society of Endocrinology: Guidelines for diagnosis and treatment of thyroid diseases in China: Hyperthyroidism. Chi J Intern Med. 46:876–882. 2007.

11 

World Health Organization. International Council for Control of Iodine Deficiency Disorders and UNICEF: Indicators for assessing Iodine Deficiency Disorders and their control through salt iodization. (1st). World Health Organization. (Geneva, Switzerland). 5–8, 13–35. 1994.

12 

Werner SC: Modification of the classification of the eye changes of Graves' disease. Am J Ophthalmol. 83:725–727. 1977. View Article : Google Scholar : PubMed/NCBI

13 

Shi BY: Antithyroid drugs: Rational and normative application all the more. Zhong Hua Nei Fen Mi Dai Xie Za Zhi. 25:245–246. 2009.(In Chinese).

14 

Bai Y: Hyperthyroidism. Thyroid disease: Basic and Clinic. 1st. Beijing Scientific and Technological Literature Publishing House. (Beijing). 244–278. 2003.

15 

Akamizu T, Moriyama K, Miura M, Saijo M, Matsuda F and Nakao K: Characterization of recombinant monoclonal antithyrotropin receptor antibodies (TSHRAbs) derived from lymphocytes of patients with Graves' disease: Epitope and binding study of two stimulatory TSHRAbs. Endocrinology. 140:1594–1601. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Cooper DS: Antithyroid drugs. N Engl J Med. 352:905–917. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Lan L, Teng WP, Shi BY, Liu XJ, Li H, Liu J, Wu XY, Xu L and Wang FX: Related factors in predicting relapse of Graves' disease after treatment with antithyroid drug. Zhong Hua Nei Fen Mi Dai Xie Za Zhi. 25:247–249. 2009.(In Chinese).

18 

Vitti P, Rago T, Chiovato L, Pallini S, Santini F, Fiore E, Rocchi R, Martino E and Pinchera A: Clinical features of patients with Graves' disease undergoing remission after antithyroid drug treatment. Thyroid. 7:369–375. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Wang PW, Liu RT, Tung SC, Chien WY, Lu YC, Chen CH, Kuo MC, Hsieh JR and Wang ST: Outcome of Graves' disease after antithyroid drug treatment in Taiwan. J Formos Med Assoc. 97:619–625. 1998.PubMed/NCBI

20 

Laurberg P: Remission of Graves' disease during anti-thyroid drug therapy. Time to reconsider the mechanism? Eur J Endocrinol. 155:783–786. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Manji N, Carr-Smith JD, Boelaert K, Allahabadia A, Armitage M, Chatterjee VK, Lazarus JH, Pearce SH, Vaidya B, Gough SC and Franklyn JA: Influences of age, gender, smoking and family history on autoimmune thyroid disease phenotype. J Clin Endocrinol Metab. 91:4873–4880. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Yoshimura Noh J, Momotani N, Fukada S, Ito K, Miyauchi A and Amino N: Ratio of serum free triiodothyronine to free thyroxine in Graves' hyperthyroidism and thyrotoxicosis caused by painless thyroiditis. Endocr J. 52:537–542. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Holm IA, Manson JE, Michels KB, Alexander EK, Willett WC and Utiger RD: Smoking and other lifestyle factors and the risk of Graves' hyperthyroidism. Arch Intern Med. 165:1606–1611. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Prummel MF and Wiersinga WM: Smoking and risk of Graves' disease. JAMA. 269:479–482. 1993. View Article : Google Scholar : PubMed/NCBI

25 

Nordyke RA, Gilbert FI Jr and Harada AS: Graves' disease. Influence of age on clinical findings. Arch Intern Med. 148:626–631. 1988. View Article : Google Scholar : PubMed/NCBI

26 

Aizawa T, Ishihara M, Hashizume K, Takasu N and Yamada T: Age-related changes of thyroid function and immunologic abnormalities in patients with hyperthyroidism due to Graves' disease. J Am Geriatr Soc. 37:944–948. 1989. View Article : Google Scholar : PubMed/NCBI

27 

Kelly GS: Peripheral metabolism of thyroid hormones: A review. Altern Med Rev. 5:306–333. 2000.PubMed/NCBI

28 

Morimoto K and Inouye K: A sensitive enzyme immunoassay of human thyroid-stimulating hormone (TSH) using bispecific F(ab')2 fragments recognizing polymerized alkaline phosphatase and TSH. J Immunol Methods. 205:81–90. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Perrin A, Theretz A and Mandrand B: Thyroid stimulating hormone assays based on the detection of gold conjugates by scanning force microscopy. Anal Biochem. 256:200–206. 1998. View Article : Google Scholar : PubMed/NCBI

30 

Lu N, Dai P, Gao A, Valiaho J, Kallio P, Wang Y and Li T: Label-free and rapid electrical detection of hTSH with CMOS-compatible silicon nanowire transistor arrays. ACS Appl Mater Interfaces. 6:20378–20384. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Quadbeck B, Janssen OE and Mann K: Problems and new developments in the management of Graves' disease: Medical therapy. Z Arztl Fortbild Qualitatssich. 98(Suppl 5): 37–44. 2004.(In German). PubMed/NCBI

32 

Maugendre D, Gatel A, Campion L, Massart C, Guilhem I, Lorcy Y, Lescouarch J, Herry JY and Allannic H: Antithyroid drugs and Graves' disease - prospective randomized assessment of long term treatment. Clin Endocrinol (Oxf). 50:127–132. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Quadbeck B, Roggenbuck U, Janssen OE, Hahn S, Mann K and Hoermann R: Basedow Study Group: Impact of smoking on the course of Graves' disease after withdrawal of antithyroid drugs. Exp Clin Endocrinol Diabetes. 114:406–411. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu L, Lu H, Liu Y, Liu C and Xun C: Predicting relapse of Graves' disease following treatment with antithyroid drugs. Exp Ther Med 11: 1453-1458, 2016.
APA
Liu, L., Lu, H., Liu, Y., Liu, C., & Xun, C. (2016). Predicting relapse of Graves' disease following treatment with antithyroid drugs. Experimental and Therapeutic Medicine, 11, 1453-1458. https://doi.org/10.3892/etm.2016.3058
MLA
Liu, L., Lu, H., Liu, Y., Liu, C., Xun, C."Predicting relapse of Graves' disease following treatment with antithyroid drugs". Experimental and Therapeutic Medicine 11.4 (2016): 1453-1458.
Chicago
Liu, L., Lu, H., Liu, Y., Liu, C., Xun, C."Predicting relapse of Graves' disease following treatment with antithyroid drugs". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1453-1458. https://doi.org/10.3892/etm.2016.3058
Copy and paste a formatted citation
x
Spandidos Publications style
Liu L, Lu H, Liu Y, Liu C and Xun C: Predicting relapse of Graves' disease following treatment with antithyroid drugs. Exp Ther Med 11: 1453-1458, 2016.
APA
Liu, L., Lu, H., Liu, Y., Liu, C., & Xun, C. (2016). Predicting relapse of Graves' disease following treatment with antithyroid drugs. Experimental and Therapeutic Medicine, 11, 1453-1458. https://doi.org/10.3892/etm.2016.3058
MLA
Liu, L., Lu, H., Liu, Y., Liu, C., Xun, C."Predicting relapse of Graves' disease following treatment with antithyroid drugs". Experimental and Therapeutic Medicine 11.4 (2016): 1453-1458.
Chicago
Liu, L., Lu, H., Liu, Y., Liu, C., Xun, C."Predicting relapse of Graves' disease following treatment with antithyroid drugs". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1453-1458. https://doi.org/10.3892/etm.2016.3058
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