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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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Case Report

Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report

  • Authors:
    • Seung‑Gu Yeo
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Soonchunhyang University College of Medicine, Soonchunhyang University Hospital, Cheonan, Chungnam 31151, Republic of Korea
  • Pages: 1465-1468
    |
    Published online on: February 9, 2016
       https://doi.org/10.3892/etm.2016.3065
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Abstract

Local excision (LE) for rectal cancer is currently indicated for selected T1 stage tumors. However, preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer not only improves local disease control, but also leads to a decrease in the stage and size of the primary mural tumor, along with a decrease in the risk of regional lymphadenopathy. The present study reports the outcome of a patient with T3N0M0 rectal cancer who was treated with LE following preoperative CRT. The distal pole of the tumor was located 2 cm from the anal verge. Preoperative pelvic radiotherapy of 50.4 Gy was administered in 28 fractions. Chemotherapy using 5‑fluorouracil and leucovorin was administered during the first and last weeks of radiotherapy. The tumor response to CRT, was found to be marked at 7 weeks after CRT completion, and a complete response was presumed clinically. Transanal full‑thickness LE was performed, and pathological examination revealed the absence of residual cancer cells. After 30 months of close follow‑up, the patient was alive with no evidence of disease, and treatment‑associated severe toxicities were not observed. Although a longer follow‑up period is required, this case report suggests that LE may also be a feasible alternative treatment for T3 rectal cancer, which exhibits a marked response to preoperative CRT, particularly in elderly and comorbid patients contraindicated for radical surgery, or patients who are reluctant to undergo sphincter-ablation surgery.
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Copy and paste a formatted citation
Spandidos Publications style
Yeo SG: Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report. Exp Ther Med 11: 1465-1468, 2016.
APA
Yeo, S. (2016). Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report. Experimental and Therapeutic Medicine, 11, 1465-1468. https://doi.org/10.3892/etm.2016.3065
MLA
Yeo, S."Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report". Experimental and Therapeutic Medicine 11.4 (2016): 1465-1468.
Chicago
Yeo, S."Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1465-1468. https://doi.org/10.3892/etm.2016.3065
Copy and paste a formatted citation
x
Spandidos Publications style
Yeo SG: Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report. Exp Ther Med 11: 1465-1468, 2016.
APA
Yeo, S. (2016). Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report. Experimental and Therapeutic Medicine, 11, 1465-1468. https://doi.org/10.3892/etm.2016.3065
MLA
Yeo, S."Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report". Experimental and Therapeutic Medicine 11.4 (2016): 1465-1468.
Chicago
Yeo, S."Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1465-1468. https://doi.org/10.3892/etm.2016.3065
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