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Candidate gene polymorphisms and risk of psoriasis: A pilot study

  • Authors:
    • Alejandra Villarreal‑Martínez
    • Hugo Gallardo‑Blanco
    • Ricardo Cerda‑Flores
    • Iris Torres‑Muñoz
    • Minerva Gómez‑Flores
    • Julio Salas‑Alanís
    • Jorge Ocampo‑Candiani
    • Laura Martínez‑Garza
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, University Hospital ‘Dr. José Eleuterio González’, Monterrey, Nuevo León 64460, México, Department of Genetics, University Hospital ‘Dr. José Eleuterio González’, Monterrey, Nuevo León 64460, México, Population Genetics Department, School of Nursing, Autonomous University of Nuevo León, Monterrey, Nuevo León 64460, México
    Copyright: © Villarreal‑Martínez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1217-1222
    |
    Published online on: February 9, 2016
       https://doi.org/10.3892/etm.2016.3066
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Abstract

Psoriasis is a complex genetic disease, which has previously been associated with numerous single nucleotide polymorphisms (SNPs) that are implicated in various processes, including skin barrier functions and in the regulation of inflammatory and immune responses. The present study aimed to investigate the genotypic and allelic frequencies of 32 SNPs at 24 genetic loci, and their association with psoriasis in a Mexican population. These SNPs, which were associated with psoriasis in previous studies, included the following genes: Major histocompatibility complex class I‑C (HLA‑C), interleukin (IL)‑12B, IL‑23R, IL‑23A, IL‑28RA, tumor necrosis factor (TNF)‑α, ring finger protein‑114 (RNF114), cyclin‑dependent kinase 5 regulatory subunit‑associated protein 1‑like 1, late cornified envelope 3B/3C, signal transducer and activator of transcription 4, LINC01185, interferon induced with helicase C domain 1, IL‑13, TNF‑α‑induced protein 3 (TNFAIP3), TNFAIP3 interacting protein 1, endoplasmic reticulum aminopeptidase 1, TNF receptor‑associated factor interacting protein 2, Leptin, nuclear factor of kappa light polypeptide gene enhancer in B‑cells inhibitor‑alpha, F‑box and leucine‑rich repeat protein 19, nitric oxide synthase 2, cluster of differentiation 40, nuclear receptor coactivator 5, and ADAM metallopeptidase domain 33. A total of 32 male and 14 female subjects with a clinical diagnosis of chronic plaque psoriasis, as well as 103 control subjects, were analyzed. Molecular analyses were performed using TaqMan® assays in a TaqMan® OpenArray® Genotyping system. Results were analyzed using the Golden Helix SNP and Variation Suite 7 program. Of the 32 SNPs, six were associated with an increased risk of developing psoriasis, including: HLA‑C rs10484554 [allele T: odds ratio (OR) 3.51], IL‑12B rs3212227 (allele T: OR 1.88), IL‑12B rs3213094 (allele C: OR 1.94), HLA complex group 27 rs1265181 (allele C: OR 2.83), annexin A6 rs17728338 (allele A: OR 2.41), and RNF114 rs6125829 (allele G: OR 1.98). Fisher's exact test detected statistical significance; however, following false discovery rate and Bonferroni correction, this association was no longer significant (threshold for genome‑wide significance, P<1.56x10‑3). SNPs that were associated with an increased risk of psoriasis in the present study have previously been associated with psoriasis in European, American, and Asian populations. In order to establish genome‑wide significance, future studies must analyze a greater sample size. To the best of our knowledge, the present pilot study is the first to investigate the association between these 32 SNPs and psoriasis in a Mexican Mestizo population.
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1 

Menter A, Gottlieb A, Feldman SR, Van Voorhees AS, Leonardi CL, Gordon KB, Lebwohl M, Koo JY, Elmets CA, et al: Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J Am Acad Dermatol. 58:826–850. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Oka A, Mabuchi T, Ozawa A and Inoko H: Current understanding of human genetics and genetic analysis of psoriasis. J Dermatol. 39:231–241. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Griffiths CE, Christophers E, Barker JN, Chalmers RJ, Chimenti S, Krueger GG, Leonardi C, Menter A, Ortonne JP and Fry L: A classification of psoriasis vulgaris according to phenotype. Br J Dermatol. 156:258–262. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, et al: Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet. 44:1341–1348. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Nestle FO, Kaplan DH and Barker J: Psoriasis. N Engl J Med. 361:496–509. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Capon F, Di Meglio P, Szaub J, Prescott NJ, Dunster C, Baumber L, Timms K, Gutin A, Abkevic V, Burden AD, et al: Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Human Genetics. 122:201–206. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Chang YT, Chou CT, Yu CW, Lin MW, Shiao YM, Chen CC, Huang CH, Lee DD, Liu HN, Wang WJ and Tsai SF: Cytokine gene polymorphisms in Chinese patients with psoriasis. Br J Dermatol. 156:899–905. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Magalhães RF, Biral AC, Pancoto JA, Donadi EA, Mendes CT Jr, Magna LA and Kraemer MH: Human leukocyte antigen (HLA) and single nucleotide polymorphisms (SNPs) tumor necrosis factor (TNF)-alpha −238 and −308 as genetic markers of susceptibility to psoriasis and severity of the disease in a long-term follow-up Brazilian study. Int J Dermatol. 49:1133–1140. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Nair RP, Henseler T, Jenisch S, Stuart P, Bichakjian CK, Lenk W, Westphal E, Guo SW, Christophers E, Voorhees JJ and Elder JT: Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan. Hum Mol Genet. 6:1349–1356. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Enlund F, Samuelsson L, Enerbäck C, Inerot A, Wahlström J, Yhr M, Torinsson A, Martinsson T and Swanbeck G: Analysis of three suggested psoriasis susceptibility loci in a large Swedish set of families: Confirmation of linkage to chromosome 6p (HLA region) and to 17q, but not to 4q. Hum Hered. 49:2–8. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Zhang XJ, He PP, Wang ZX, Zhang J, Li YB, Wang HY, Wei SC, Chen SY, Xu SJ, Jin L, et al: Evidence for a major psoriasis susceptibility locus at 6p21 (PSORS1) and a novel candidate region at 4q31 by genome-wide scan in Chinese hans. J Invest Dermatol. 119:1361–1366. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2. Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, et al: A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet. 42:985–990. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Zhang XJ, Huang W, Yang S, Sun LD, Zhang FY, Zhu QX, Zhang FR, Zhang C, Du WH, Pu XM, et al: Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet. 41:205–210. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Zhu KJ, Lv YM, Yin XY, Wang ZX, Sun LD, He SM, Cheng H, Hu DY, Zhang Z, Li Y, et al: Psoriasis regression analysis of MHC loci identifies shared genetic variants with vitiligo. PloS One. 6:e230892011. View Article : Google Scholar : PubMed/NCBI

15 

Capon F, Bijlmakers MJ, Wolf N, Quaranta M, Huffmeier U, Allen M, Timms K, Abkevich V, Gutin A, Smith R, et al: Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. Hum Mol Genet. 17:1938–1945. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, Matsunami N, Ardlie KG, Civello D, Catanese JJ, et al: A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 80:273–290. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Nair RP, Ruether A, Stuart PE, Jenisch S, Tejasvi T, Hiremagalore R, Schreiber S, Kabelitz D, Lim HW, Voorhees JJ, et al: Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol. 128:1653–1661. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Chien AL, Elder JT and Ellis CN: Ustekinumab: A new option in psoriasis therapy. Drugs. 69:1141–1152. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Gandhi M, Alwawi E and Gordon KB: Anti-p40 antibodies ustekinumab and briakinumab: blockade of interleukin-12 and interleukin-23 in the treatment of psoriasis. Seminars in cutaneous medicine and surgery. 29:48–52. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Griffiths CE, Strober BE, van de Kerkhof P, Ho V, Fidelus-Gort R, Yeilding N, Guzzo C, Xia Y, Zhou B, Li S, et al: Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis. N Engl J Med. 362:118–128. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Kurzeja M, Rudnicka L and Olszewska M: New interleukin-23 pathway inhibitors in dermatology: Ustekinumab, briakinumab and secukinumab. Am J Clin Dermatol. 12:113–125. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Cornely R, Rentero C, Enrich C, Grewal T and Gaus K: Annexin A6 is an organizer of membrane microdomains to regulate receptor localization and signalling. IUBMB life. 63:1009–1017. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Sun LD, Cheng H, Wang ZX, Zhang AP, Wang PG, Xu JH, Zhu QX, Zhou HS, Ellinghaus E, Zhang FR, et al: Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nature Genet. 42:1005–1009. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Villarreal‑Martínez A, Gallardo‑Blanco H, Cerda‑Flores R, Torres‑Muñoz I, Gómez‑Flores M, Salas‑Alanís J, Ocampo‑Candiani J and Martínez‑Garza L: Candidate gene polymorphisms and risk of psoriasis: A pilot study. Exp Ther Med 11: 1217-1222, 2016.
APA
Villarreal‑Martínez, A., Gallardo‑Blanco, H., Cerda‑Flores, R., Torres‑Muñoz, I., Gómez‑Flores, M., Salas‑Alanís, J. ... Martínez‑Garza, L. (2016). Candidate gene polymorphisms and risk of psoriasis: A pilot study. Experimental and Therapeutic Medicine, 11, 1217-1222. https://doi.org/10.3892/etm.2016.3066
MLA
Villarreal‑Martínez, A., Gallardo‑Blanco, H., Cerda‑Flores, R., Torres‑Muñoz, I., Gómez‑Flores, M., Salas‑Alanís, J., Ocampo‑Candiani, J., Martínez‑Garza, L."Candidate gene polymorphisms and risk of psoriasis: A pilot study". Experimental and Therapeutic Medicine 11.4 (2016): 1217-1222.
Chicago
Villarreal‑Martínez, A., Gallardo‑Blanco, H., Cerda‑Flores, R., Torres‑Muñoz, I., Gómez‑Flores, M., Salas‑Alanís, J., Ocampo‑Candiani, J., Martínez‑Garza, L."Candidate gene polymorphisms and risk of psoriasis: A pilot study". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1217-1222. https://doi.org/10.3892/etm.2016.3066
Copy and paste a formatted citation
x
Spandidos Publications style
Villarreal‑Martínez A, Gallardo‑Blanco H, Cerda‑Flores R, Torres‑Muñoz I, Gómez‑Flores M, Salas‑Alanís J, Ocampo‑Candiani J and Martínez‑Garza L: Candidate gene polymorphisms and risk of psoriasis: A pilot study. Exp Ther Med 11: 1217-1222, 2016.
APA
Villarreal‑Martínez, A., Gallardo‑Blanco, H., Cerda‑Flores, R., Torres‑Muñoz, I., Gómez‑Flores, M., Salas‑Alanís, J. ... Martínez‑Garza, L. (2016). Candidate gene polymorphisms and risk of psoriasis: A pilot study. Experimental and Therapeutic Medicine, 11, 1217-1222. https://doi.org/10.3892/etm.2016.3066
MLA
Villarreal‑Martínez, A., Gallardo‑Blanco, H., Cerda‑Flores, R., Torres‑Muñoz, I., Gómez‑Flores, M., Salas‑Alanís, J., Ocampo‑Candiani, J., Martínez‑Garza, L."Candidate gene polymorphisms and risk of psoriasis: A pilot study". Experimental and Therapeutic Medicine 11.4 (2016): 1217-1222.
Chicago
Villarreal‑Martínez, A., Gallardo‑Blanco, H., Cerda‑Flores, R., Torres‑Muñoz, I., Gómez‑Flores, M., Salas‑Alanís, J., Ocampo‑Candiani, J., Martínez‑Garza, L."Candidate gene polymorphisms and risk of psoriasis: A pilot study". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1217-1222. https://doi.org/10.3892/etm.2016.3066
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