Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2016 Volume 11 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2016 Volume 11 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Impact of combined treatment with rosuvastatin and antidepressants on liver and kidney function in rats

  • Authors:
    • Mariola Herbet
    • Monika Gawrońska‑Grzywacz
    • Magdalena Izdebska
    • Iwona Piątkowska‑Chmiel
    • Ewa Jagiełło‑Wójtowicz
  • View Affiliations / Copyright

    Affiliations: Chair and Department of Toxicology, Medical University of Lublin, Lublin 20‑093, Poland
  • Pages: 1459-1464
    |
    Published online on: February 10, 2016
       https://doi.org/10.3892/etm.2016.3068
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Depression is among the most prevalent and life-threatening forms of mental illness, and is also a risk factor for cardiovascular disorders, diabetes and metabolic syndrome. Elderly patients commonly receive statins for the prevention of cardiovascular diseases, and antidepressant drugs for the treatment of depression. It should be noted that long‑term polypharmacotherapy may lead to potential drug interactions and disorders of the organs. The aim of the present study was to determine whether, and to what extent, combined treatment with rosuvastatin and antidepressants (amitriptyline or fluoxetine) influences the biochemical markers of liver and kidney function in a rat model. For this purpose, the activity levels of aspartate aminotransferase, alanine aminotransferase (ALT), γ‑glutamyltransferase (GGT) and the concentrations of total protein, urea, creatinine and β2‑microglobulin were determined. The results of the study indicated that combined treatment with rosuvastatin and the antidepressants amitriptyline and fluoxetine for 14 days altered the activity levels of ALT and GGT, and the concentrations of urea and creatinine in the serum compared with groups of rats receiving rosuvastatin or either antidepressant alone. These observed changes in biochemical parameters may suggest the possibility of impaired liver and kidney function during the continuous combined exposure to the drugs. However, further clinical and animal studies are required in order to further elucidate this process.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Elderon L and Whooley MA: Depression and Cardiovascular Disease. Prog Cardiovasc Dis. 55:511–523. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Rugulies R: Depression as a predictor for coronary heart disease. A review and meta-analysis. Am J Prev Med. 23:51–61. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Ramasubbu R and Patten SB: Effect of depression on stroke morbidity and mortality. Can J Psychiatry. 48:250–257. 2003.PubMed/NCBI

4 

Luvai A, Mbagaya W, Hall AS and Barth JH: Rosuvastatin: A review of the pharmacology and clinical effectiveness in cardiovascular disease. Clin Med Insights Cardiol. 6:17–33. 2012.PubMed/NCBI

5 

You H, Lu W, Zhao S, Hu Z and Zhang J: The relationship between statins and depression: A review of the literature. Expert Opin Pharmacother. 14:1467–1476. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Guthrie RM and Martin DR: The safety of rosuvastatin: Effect of renal and hepatic function. Expert Opin Drug Saf. 6:573–581. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Chan KL, Dumesnil JG, Tam J, Ni A and Teo K: Effect of rosuvastatin on C-reactive protein and progression of aortic stenosis. Am Heart J. 161:1133–1139. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Cohen DE, Anania FA and Chalasani N: National Lipid Association Statin Safety Task Force Liver Expert Panel: An assessment of statin safety by hepatologists. Am J Cardiol. 97:77C–81C. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Soran H and Durrington P: Rosuvastatin: Efficacy, safety and clinical effectiveness. Expert Opin Pharmacother. 9:2145–2160. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Jian W and Davidson JR: Antidepressant therapy in patients with ischemic heart disease. Am Heart J. 150:871–881. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Leucht C, Huhn M and Leucht S: Amitriptyline versus placebo for major depressive disorder. Cochrane Database Syst Rev. 12:CD0091382012.PubMed/NCBI

12 

von Moltke LL, Greenblatt DJ and Shader RI: Clinical pharmacokinetics of antidepressants in the elderly. Therapeutic implications. Clin Pharmacokinet. 24:141–160. 1993. View Article : Google Scholar : PubMed/NCBI

13 

Roose SP, Glassman AH, Attia E, Woodring S, Giardina EG and Bigger JT Jr: Cardiovascular effects of fluoxetine in depressed patients with heart disease. Am J Psychiatry. 155:660–665. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Brambilla P, Cipriani A, Hotopf M and Barbui C: Side-effect profile of fluoxetine in comparison with other SSRIs, tricyclic and newer antidepressants: A meta-analysis of clinical trial data. Pharmacopsychiatry. 38:69–77. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Castiella A and Arenas J: Fluoxetine hepatotoxicity. Am J Gastroenterol. 89:458–459. 1994.PubMed/NCBI

16 

Inkielewicz-Stępniak I: Impact of fluoxetine on liver damage in rats. Pharmacol Rep. 63:441–447. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Mavrides N and Nemeroff C: Treatment of depression in cardiovascular disease. Depress Anxiety. 30:328–341. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Herbet M, Gawrońska-Grzywacz M and Jagiełło-Wójtowicz E: The influence of combined treatment of simvastatin and amitriptyline on some biochemical parameters in rat serum. Ann UMCS Sect DDD. 23:121–127. 2010.

19 

Herbet M, Gawrońska-Grzywacz M, Kwiatek K and Jagiełło-Wójtowicz E: Evaluation of selected biochemical parameters in the serum of rats pretreated with simvastatin, doxepin or their combination. Ann UMCS Sect DDD. 24:107–113. 2011.

20 

Karnik NS and Maldonaldo JR: Antidepressant and statin interactions: A review and case report of simvastatin and nefazodone-induced rhabdomyolysis and transaminitis. Psychosomatics. 46:565–568. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Kasiske BL, Wanner C and O'Neill WC: An Assessment of statin safety by nephrologists. Am J Cardiol. 97:82C–85C. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Levy NB, Blumenfield M, Beasley CM Jr, Dubey AK, Solomon RJ, Todd R, Goodman A and Bergstrom RR: Fluoxetine in depressed patients with renal failure and in depressed patients with normal kidney function. Gen Hosp Psychiatry. 18:8–13. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Blumenfield M, Levy NB, Spinowitz B, Charytan C, Beasley CM Jr, Dubey AK, Solomon RJ, Todd R, Goodman A and Bergstrom RF: Fluoxetine in depressed patients on dialysis. Int J Psychiatry Med. 27:71–80. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Vasudevan AR, Hamirani YS and Jones PH: Safety of statins: Effects on muscle and the liver. Cleve Clin J Med. 72:990–993. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Zhang LS, Liu ZX, Lü W and Hu XY: Effects of statins on the liver: Clinical analysis of patients with ischemic stroke. Chin Med J (Engl). 124:897–900. 2011.PubMed/NCBI

26 

Wille SM, Cooreman SG, Neels HM and Lambert WE: Relevant issues in the monitoring and the toxicology of antidepressants. Crit Rev Clin Lab Sci. 45:25–89. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Wen B, Ma L and Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 173:59–67. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Apella D, Bruguera M, Figueras A and Laporte J: Fluoxetine-induced hepatitis: Why is postmarketing surveillance needed? Eur J Clin Pharmacol. 55:545–546. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Mandrioli R, Forti GC and Raggi MA: Fluoxetine metabolism and pharmacological interactions: The role of cytochrome P450. Curr Drug Metab. 7:127–133. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Herbet M, Gawrońska‑Grzywacz M, Izdebska M, Piątkowska‑Chmiel I and Jagiełło‑Wójtowicz E: Impact of combined treatment with rosuvastatin and antidepressants on liver and kidney function in rats. Exp Ther Med 11: 1459-1464, 2016.
APA
Herbet, M., Gawrońska‑Grzywacz, M., Izdebska, M., Piątkowska‑Chmiel, I., & Jagiełło‑Wójtowicz, E. (2016). Impact of combined treatment with rosuvastatin and antidepressants on liver and kidney function in rats. Experimental and Therapeutic Medicine, 11, 1459-1464. https://doi.org/10.3892/etm.2016.3068
MLA
Herbet, M., Gawrońska‑Grzywacz, M., Izdebska, M., Piątkowska‑Chmiel, I., Jagiełło‑Wójtowicz, E."Impact of combined treatment with rosuvastatin and antidepressants on liver and kidney function in rats". Experimental and Therapeutic Medicine 11.4 (2016): 1459-1464.
Chicago
Herbet, M., Gawrońska‑Grzywacz, M., Izdebska, M., Piątkowska‑Chmiel, I., Jagiełło‑Wójtowicz, E."Impact of combined treatment with rosuvastatin and antidepressants on liver and kidney function in rats". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1459-1464. https://doi.org/10.3892/etm.2016.3068
Copy and paste a formatted citation
x
Spandidos Publications style
Herbet M, Gawrońska‑Grzywacz M, Izdebska M, Piątkowska‑Chmiel I and Jagiełło‑Wójtowicz E: Impact of combined treatment with rosuvastatin and antidepressants on liver and kidney function in rats. Exp Ther Med 11: 1459-1464, 2016.
APA
Herbet, M., Gawrońska‑Grzywacz, M., Izdebska, M., Piątkowska‑Chmiel, I., & Jagiełło‑Wójtowicz, E. (2016). Impact of combined treatment with rosuvastatin and antidepressants on liver and kidney function in rats. Experimental and Therapeutic Medicine, 11, 1459-1464. https://doi.org/10.3892/etm.2016.3068
MLA
Herbet, M., Gawrońska‑Grzywacz, M., Izdebska, M., Piątkowska‑Chmiel, I., Jagiełło‑Wójtowicz, E."Impact of combined treatment with rosuvastatin and antidepressants on liver and kidney function in rats". Experimental and Therapeutic Medicine 11.4 (2016): 1459-1464.
Chicago
Herbet, M., Gawrońska‑Grzywacz, M., Izdebska, M., Piątkowska‑Chmiel, I., Jagiełło‑Wójtowicz, E."Impact of combined treatment with rosuvastatin and antidepressants on liver and kidney function in rats". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1459-1464. https://doi.org/10.3892/etm.2016.3068
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team