Elevated interleukin-6 expression levels are associated with intervertebral disc degeneration

Deng,Xiao; Zhao,Feng; Kang,Baolin; Zhang,Xin

doi:10.3892/etm.2016.3079

Elevated interleukin-6 expression levels are associated with intervertebral disc degeneration

Authors:
- Xiao Deng
- Feng Zhao
- Baolin Kang
- Xin Zhang
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Affiliations: Department of Orthopedics, Shaanxi Sengong Hospital, Xi'an, Shaanxi 710300, P.R. China
Published online on: February 16, 2016 https://doi.org/10.3892/etm.2016.3079
Pages: 1425-1432

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Abstract

The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral disc degeneration (IDD). A comprehensive meta‑analysis of the scientific literature from numerous electronic databases was performed, in order to obtain published studies associated with the topic of interest. Relevant case‑control studies that had previously assessed a correlation between IL‑6 expression levels and IDD were identified using predetermined inclusion and exclusion criteria. The STATA version 12.0 software was used for statistical analysis of the extracted data. A total of 112 studies were initially retrieved, with eight studies meeting the inclusion criteria. These contained a total of 392 subjects, of which 263 were patients with IDD and 129 were healthy controls. A meta‑analysis of the eight studies demonstrated that serum IL‑6 protein expression levels may be associated with IDD, and this was irrespective of IDD subtype (bulging, protrusion, or sequestration). Notably, serum expression levels of the IL‑6 protein were upregulated in intervertebral disc (IVD) protrusion tissue, as compared with normal IVD tissue; thus suggesting that IL-6 may have an important role in the pathophysiological process of IDD.

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