Open Access

Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery

  • Authors:
    • Xiao Liu
    • Xiaopeng Liu
    • Ruike Wang
    • Hui Luo
    • Gang Qin
    • Lu Wang
    • Zhi Ye
    • Qulian Guo
    • E Wang
  • View Affiliations

  • Published online on: March 24, 2016     https://doi.org/10.3892/etm.2016.3197
  • Pages: 2270-2276
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In patients undergoing off‑pump coronary artery bypass surgery (OPCAB), it is important to attenuate myocardium injury during the surgery. The present study aimed to observe the cardioprotection induced by sevoflurane induction and maintenance compared with propofol intravenous anesthesia, and to detect its potential protection against acute myocardial injury with sensitive biomarkers. In total, 36 patients undergoing OPCAB were randomly assigned into two groups, receiving sevoflurane (n=18) or propofol (n=18) as the induction and maintenance anesthetic agent. The depth of anesthesia in the two groups was kept at a bispectral index value of 40‑50. Physiological and hemodynamic parameters were recorded during the surgery. Cardiac troponin‑I (cTnI), creatine kinase‑MB (CK‑MB), lactate dehydrogenase (LDH) and two microRNAs (miR‑499 and miR‑208b) were also measured during and subsequent to surgery. Nno statistically significant differences were observed in the physiological and hemodynamic parameters between the two groups prior to surgery. Following surgery, the cardiac output and stroke volume improved significantly in the sevoflurane group (P<0.05). In addition, patients in the sevoflurane group had lower miR‑499 (P<0.05) and miR‑208b (P<0.01) levels at 12 h after surgery when compared with the propofol group. However, no significant differences in cTnI, CK‑MB and LDH levels were observed following surgery between the two groups. In conclusion, volatile induction and maintenance with sevoflurane resulted in some extent of cardiac function improvement in patients undergoing OPCAB. Cardioprotection by sevoflurane is suggested by reduced cardiac injury compared with propofol, and indicated by the sensitive biomarkers, circulating miR‑499 and miR‑208b.
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June-2016
Volume 11 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Liu X, Liu X, Wang R, Luo H, Qin G, Wang L, Ye Z, Guo Q and Wang E: Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery. Exp Ther Med 11: 2270-2276, 2016
APA
Liu, X., Liu, X., Wang, R., Luo, H., Qin, G., Wang, L. ... Wang, E. (2016). Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery. Experimental and Therapeutic Medicine, 11, 2270-2276. https://doi.org/10.3892/etm.2016.3197
MLA
Liu, X., Liu, X., Wang, R., Luo, H., Qin, G., Wang, L., Ye, Z., Guo, Q., Wang, E."Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery". Experimental and Therapeutic Medicine 11.6 (2016): 2270-2276.
Chicago
Liu, X., Liu, X., Wang, R., Luo, H., Qin, G., Wang, L., Ye, Z., Guo, Q., Wang, E."Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2270-2276. https://doi.org/10.3892/etm.2016.3197