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Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery

  • Authors:
    • Xiao Liu
    • Xiaopeng Liu
    • Ruike Wang
    • Hui Luo
    • Gang Qin
    • Lu Wang
    • Zhi Ye
    • Qulian Guo
    • E Wang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2270-2276
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    Published online on: March 24, 2016
       https://doi.org/10.3892/etm.2016.3197
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Abstract

In patients undergoing off‑pump coronary artery bypass surgery (OPCAB), it is important to attenuate myocardium injury during the surgery. The present study aimed to observe the cardioprotection induced by sevoflurane induction and maintenance compared with propofol intravenous anesthesia, and to detect its potential protection against acute myocardial injury with sensitive biomarkers. In total, 36 patients undergoing OPCAB were randomly assigned into two groups, receiving sevoflurane (n=18) or propofol (n=18) as the induction and maintenance anesthetic agent. The depth of anesthesia in the two groups was kept at a bispectral index value of 40‑50. Physiological and hemodynamic parameters were recorded during the surgery. Cardiac troponin‑I (cTnI), creatine kinase‑MB (CK‑MB), lactate dehydrogenase (LDH) and two microRNAs (miR‑499 and miR‑208b) were also measured during and subsequent to surgery. Nno statistically significant differences were observed in the physiological and hemodynamic parameters between the two groups prior to surgery. Following surgery, the cardiac output and stroke volume improved significantly in the sevoflurane group (P<0.05). In addition, patients in the sevoflurane group had lower miR‑499 (P<0.05) and miR‑208b (P<0.01) levels at 12 h after surgery when compared with the propofol group. However, no significant differences in cTnI, CK‑MB and LDH levels were observed following surgery between the two groups. In conclusion, volatile induction and maintenance with sevoflurane resulted in some extent of cardiac function improvement in patients undergoing OPCAB. Cardioprotection by sevoflurane is suggested by reduced cardiac injury compared with propofol, and indicated by the sensitive biomarkers, circulating miR‑499 and miR‑208b.
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1 

Parissis H, Mbarushimana S, Ramesh BC, Parissis M, Lampridis S, Mhandu P and Al-Alao B: The impact of off-pump surgery in end-organ function: Practical end-points. J Cardiothorac Surg. 10:1582015. View Article : Google Scholar : PubMed/NCBI

2 

Gonenc A, Hacişevki A, Griffiths HR, Torun M, Bakkaloglu B and Simsek B: Free radical reaction products and antioxidant capacity in beating coronary artery surgery compared to conventional bypass. Biochemistry (Mosc). 76:677–685. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Leslie JB: Incidence and aetiology of perioperative hypertension. Acta Anaesthesiol Scand Suppl. 99:5–9. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Yao YT, Fang NX, Shi CX and Li LH: Sevoflurane postconditioning protects isolated rat hearts against ischemia-reperfusion injury. Chin Med J (Engl). 123:1320–1328. 2010.PubMed/NCBI

5 

Coetzee JF, Roux PJ, Genade S and Lonchner A: Reduction of postischemic contractile dysfunction of the isolated rat heart by sevoflurane: Comparison with halothane. Anesth Analg. 90:1089–1097. 2000. View Article : Google Scholar : PubMed/NCBI

6 

De Hert SG, Broecke PW, Mertens E, Van Sommeren EW, De Blier IG, Stockman BA and Rodrigus IE: Sevoflurane but not propofol preserves myocardial function in coronary surgery patients. Anesthesiology. 97:42–49. 2002. View Article : Google Scholar : PubMed/NCBI

7 

De Hert SG, Van der Linden PJ, Cromheecke S, Meeus R, Nelis A, Van Reeth V, ten Broecke PW, De Blier IG, Stockman BA and Rodrigus IE: Cardioprotective properties of sevoflurane in patients undergoing coronary surgery with cardiopulmonary bypass are related to the modalities of its administration. Anesthesiology. 101:299–310. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Haroun-Bizri S, Khoury SS, Chehab IR, Kassas CM and Baraka A: Does isoflurane optimize myocardial protection during cardiopulmonary bypass? J Cardiothorac Vasc Anesth. 15:418–421. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Julier K, da Silva R, Garcia C, Bestmann L, Frascarolo P, Zollinger A, Chassot PG, Schmid ER, Turina MI, von Segesser LK, et al: Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: A double-blinded, placebo-controlled, multicenter study. Anesthesiology. 98:1315–1327. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Fisher LA, Beckman JA, Brown KA, Calkins H, Chaikof E, Fleischmann KE, Freeman WK, Froehlich JB, Kasper EK, Kersten JR, et al: ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: A report of the American college of cardiology/American heart association task force on practice guidelines. Circulation. 116:e418–e499. 2007.PubMed/NCBI

11 

Landoni G, Bignami E, Oliviero F and Zangrillo A: Halogenated anaedthetics and cardiac protection in cardiac and non-cardiac anesthesia. Ann Card Anesth. 12:4–9. 2009. View Article : Google Scholar

12 

Landoni G, Biondi-Zoccai GG, Zangrillo A, Bignami E, D'Avolio S, Marchetti C, Calabrò MG, Fochi O, Guarracino F, Tritapepe L, et al: Desflurane and sevoflurane in cardiac surgery: A meta-analysis of randomized clinical trials. J Cardiothorac Vasc Anesth. 21:502–511. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Hamm CW, Goldmann BU, Heeschen C, Kreymann G, Berger J and Meinertz T: Emergency room triage of patients with acute chest based on rapid testing for troponin T or troponin I. N Engl J Med. 337:1648–1653. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Davies E, Gawad Y, Takahashi M, Shi Q, Lam P, Styba G, Lau A, Heeschen C, Usategui M and Jackowski G: Analytical performance and clinical utility of a sensitive immunoassay for determination of human cardiac troponin I. Clin Biochem. 30:479–490. 1997. View Article : Google Scholar : PubMed/NCBI

15 

Lewandrowski K, Chen A and Januzzi J: Cardiac markers for myocardial infarction. Am J Clin Pathol. 118(Suppl): S93–S99. 2002.PubMed/NCBI

16 

Dekker MS, Mosterd A, van't Hof AW and Hoes AW: Novel biochemical markers in suspected acute coronary syndrome: Systematic review and critical appraisal. Heart. 96:1001–1010. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP and Burge CB: Prediction of mammalian microRNA targets. Cell. 115:787–798. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Sluijter JP, van Mil A, van Vliet P, Metz CH, Liu J, Doevendans PA and Goumans MJ: MicroRNA-1 and −499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells. Arterioscler Thromb Vasc Biol. 30:859–868. 2010. View Article : Google Scholar : PubMed/NCBI

19 

van Rooij E, Sutherland LB, Liu N, Williams AH, McAnally J, Gerard RD, Richardson JA and Olson EN: A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci USA. 103:18255–18260. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Oerlemans MI, Mosterd A, Dekker MS, de Vrey EA, van Mil A, Pasterkamp G, Doevendans PA, Hoes AW and Sluijter JP: Early assessment of acute coronary syndromes in the emergency department: The potential diagnostic value of circulating microRNAs. EMBO Mol Med. 4:1176–1185. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Devaux Y, Vausort M, Goretti E, Nazarov PV, Azuaje F, Gilson G, Corsten MF, Schroen B, Lair ML and Heymans S: Use of circulating microRNAs to diagnose acute myocardial infarction. Clin Chem. 58:559–567. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Lequin RM: Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA). Clin Chem. 51:2415–2418. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Qiao S, Xie H, Wang C, Wu X, Liu H and Liu C: Delayed anesthetic preconditioning protects against myocardial infarction via activation of nuclear factor-κB and upregulation of autophagy. J Anesth. 27:251–260. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Torina AG, Reichert K, Lima F, de Souza Vilarinho KA, de Oliveira PP, do Carmo HR, de Carvalho DD, Saad MJ, Sposito AC and Petrucci O: Diacerein improves left ventricular remodeling and cardiac function by reducing the inflammatory response after myocardial infarction. PLoS One. 10:e01218422015. View Article : Google Scholar : PubMed/NCBI

26 

Wu X, He L, Chen F, He X, Cai Y, Zhang G, Yi Q, He M and Luo J: Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction. PLoS One. 9:e1128912014. View Article : Google Scholar : PubMed/NCBI

27 

Liu Q: Lentivirus mediated interference of Caspase-3 expression ameliorates the heart function on rats with acute myocardial infarction. Eur Rev Med Pharmacol Sci. 18:1852–1858. 2014.PubMed/NCBI

28 

Zhao J, Wang F, Zhang Y, Jiao L, Lau WB, Wang L, Liu B, Gao E, Koch WJ and Ma XL: Sevoflurane preconditioning attenuates myocardial ischemia/reperfusion injury via caveolin-3-dependent cyclooxygenase-2 inhibition. Circulation. 128(11 Suppl 1): S121–S129. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Yao YY, Zhu MH, Zhang FJ, Wen CY, Ma LL, Wang WN, Wang CC, Liu XB, Yu LN, Qian LB, et al: Activation of Akt and cardioprotection against reperfusion injury are maximal with only five minutes of sevoflurane post-conditioning in isolated rat hearts. J Zhejiang Univ Sci B. 14:511–517. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Zaugg M, Wang L, Zhang L, Lou PH, Lucchinetti E and Clanachan AS: Choice of anesthetic combination determines Ca2+ leak after ischemia-reperfusion injury in the working rat heart: Favorable versus adverse combinations. Anesthesiology. 116:648–657. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Samir A, Gandreti N, Madhere M, Khan A, Brown M and Loomba V: Anti-inflammatory effects of propofol during cardiopulmonary bypass: A pilot study. Ann Card Anaesth. 18:495–501. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Xia WF, Liu Y, Zhou QS, Tang QZ and Zou HD: Protective effect of propofol and its relation to postoperation recovery in children undergoing cardiac surgery with cardiopulmonary bypass. Pediatr Cardiol. 32:940–946. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Jovic M, Stancic A, Nenadic D, Cekic O, Nezic D, Milojevic P, Micovic S, Buzadzic B, Korac A, Otasevic V, et al: Mitochondrial molecular basis of sevoflurane and propofol cardioprotection in patients undergoing aortic valve replacement with cardiopulmonary bypass. Cell Physiol Biochem. 29:131–142. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Ballester M, Llorens J, Garcia-de-la-Asuncion J, Perez-Griera J, Tebar E, Martinez-Leon J, Belda J and Juez M: Myocardial oxidative stress protection by sevoflurane vs. propofol: A randomised controlled study in patients undergoing off-pump coronary artery bypass graft surgery. Eur J Anaesthesiol. 28:874–881. 2011. View Article : Google Scholar : PubMed/NCBI

35 

El Azab SR, Scheffer GJ, Rosseel PM and De Lange JJ: Induction and maintenance of anaesthesia with sevoflurane in comparison to high dose opioid during coronary artery bypass surgery. Eur J Anaesthesiol. 17:336–338. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Futterman LG and Lemberg L: SGOT, LDH, HBD, CPK, CK-MB, MB1MB2, cTnT, cTnC, cTnI. Am J Crit Care. 6:333–338. 1997.PubMed/NCBI

37 

Law-Koune JD, Raynaud C, Liu N, Dubois C, Romano M and Fischler M: Sevoflurane-remifentanyl versus propofol-remifentanyl anesthesia at a similar bispectral level for off-pump coronary artery surgery: No evidence of reduced myocardial ischemia. J Cardiothorac Vasc Anesth. 20:484–492. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Hemmerling T, Olivier J, Le N, Prieto I and Bracco D: Myocardial protection by isoflurane vs. sevoflurane in ultra-fast-track anaesthesia for off-pump aortocoronary bypass grafting. Eur J Anaesthesiol. 25:230–236. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Conzen PF, Fischer S, Detter C and Peter K: Sevoflurane provides greater protection of the myocardium than propofol in patients undergoing off-pump coronary artery bypass surgery. Anesthesiology. 99:826–833. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Riess ML, Kevin LG, Camara AK, Heisner JS and Stowe DF: Dual exposure to sevoflurane improves anesthetic preconditioning in intact hearts. Anesthesiology. 100:569–574. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Piriou V, Mantz J, Goldfarb G, Kitakaze M, Chiari P, Paquin S, Cornu C, Lecharny JB, Aussage P, Vicaut E, et al: Sevoflurane preconditioning at 1 MAC only provides limited protection in patients undergoing coronary artery bypass surgery: A randomized bi-centre trial. Br J Anaesth. 99:624–631. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Vikenes K, Andersen KS, Melberg T, Farstad M and Nordrehaug JE: Long-term prognostic value of cardiac troponin I and T versus creatine kinase-MB mass after cardiac surgery in low-risk patients with stable symptoms. Am J Cardiol. 106:780–786. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Ekaney ML, Otto GP, Sossdorf M, Sponholz C, Boehringer M, Loesche W, Rittirsch D, Wilharm A, Kurzai O, Bauer M and Claus RA: Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation. Crit Care. 18:5432014. View Article : Google Scholar : PubMed/NCBI

44 

De Rosa S and Indolfi C: Circulating microRNAs as Biomarkers in Cardiovascular Diseases. EXS. 106:139–149. 2015.PubMed/NCBI

45 

Schulte C, Molz S, Appelbaum S, Karakas M, Ojeda F, Lau DM, Hartmann T, Lackner KJ, Westermann D, Schnabel RB, et al: miRNA-197 and miRNA-223 Predict Cardiovascular Death in a Cohort of Patients with Symptomatic Coronary Artery Disease. PLoS One. 10:e01459302015. View Article : Google Scholar : PubMed/NCBI

46 

Ji X, Takahashi R, Hiura Y, Hirokawa G, Fukushima Y and Iwai N: Plasma miR-208 as a biomarker of myocardial injury. Clin Chem. 55:1944–1949. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Reddy A, Zheng Y, Jagadeeswaran G, Macmil SL, Graham WB, Roe BA, Desilva U, Zhang W and Sunkar R: Cloning, characterization and expression analysis of porcine microRNAs. BMC genomics. 10:652009. View Article : Google Scholar : PubMed/NCBI

48 

Gidlöf O, Andersson P, van der Pals J, Götberg M and Erlinge D: Cardiospecific microRNA plasa levels correlate with troponin and cardiac function in patients with ST elevation myocardial infarction, are selectively dependent on renal elimination and can be detected in urine samples. Cardiology. 118:217–226. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Olivieri F, Antonicelli R, Lorenzi M, D'Alessandra Y, Lazzarini R, Santini G, Spazzafumo L, Lisa R, La Sala L, Galeazzi R, et al: Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction. Int J Cardiol. 167:531–536. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Gidlof O, Smith JG, Miyazu K, Gilje P, Spencer A, Blomquist S and Erlinge D: Circulating cardio-enriched microRNAs are associated with long-term prognosis following myocardial infarction. BMC Cardiovasc Disord. 13:122013. View Article : Google Scholar : PubMed/NCBI

51 

Corsten MF, Dennert R, Jochems S, Kuznetsova T, Devaux Y, Hofstra L, Wagner DR, Staessen JA, Heymans S and Schroen B: Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease. Circ Cardiovasc Genet. 3:499–506. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Ishikawa M, Tanaka S, Arai M, Genda Y and Sakamoto A: Differences in microRNA changes of healthy rat liver between sevoflurane and propofol anesthesia. Anesthesiology. 117:1245–1252. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Tanaka S, Ishikawa M, Arai M, Genda Y and Sakamoto A: Changes in microRNA expression in rat lungs caused by sevoflurane anesthesia: A TaqMan® low-density array study. Biomed Res. 33:255–263. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Liu X, Wang R, Luo H, Qin G, Wang L, Ye Z, Guo Q and Wang E: Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery. Exp Ther Med 11: 2270-2276, 2016.
APA
Liu, X., Liu, X., Wang, R., Luo, H., Qin, G., Wang, L. ... Wang, E. (2016). Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery. Experimental and Therapeutic Medicine, 11, 2270-2276. https://doi.org/10.3892/etm.2016.3197
MLA
Liu, X., Liu, X., Wang, R., Luo, H., Qin, G., Wang, L., Ye, Z., Guo, Q., Wang, E."Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery". Experimental and Therapeutic Medicine 11.6 (2016): 2270-2276.
Chicago
Liu, X., Liu, X., Wang, R., Luo, H., Qin, G., Wang, L., Ye, Z., Guo, Q., Wang, E."Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2270-2276. https://doi.org/10.3892/etm.2016.3197
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Liu X, Wang R, Luo H, Qin G, Wang L, Ye Z, Guo Q and Wang E: Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery. Exp Ther Med 11: 2270-2276, 2016.
APA
Liu, X., Liu, X., Wang, R., Luo, H., Qin, G., Wang, L. ... Wang, E. (2016). Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery. Experimental and Therapeutic Medicine, 11, 2270-2276. https://doi.org/10.3892/etm.2016.3197
MLA
Liu, X., Liu, X., Wang, R., Luo, H., Qin, G., Wang, L., Ye, Z., Guo, Q., Wang, E."Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery". Experimental and Therapeutic Medicine 11.6 (2016): 2270-2276.
Chicago
Liu, X., Liu, X., Wang, R., Luo, H., Qin, G., Wang, L., Ye, Z., Guo, Q., Wang, E."Circulating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off‑pump coronary artery bypass surgery". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2270-2276. https://doi.org/10.3892/etm.2016.3197
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