Study on the inflammatory intervention of erythropoietin on NEC

Qi,Weibin; Shen,Qiong; Zhang,Lin; Han,Li‑Ping; Wang,Sumin

doi:10.3892/etm.2016.3199

Study on the inflammatory intervention of erythropoietin on NEC

Authors:
- Weibin Qi
- Qiong Shen
- Lin Zhang
- Li‑Ping Han
- Sumin Wang
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Affiliations: Department of Neonatology, The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei 050011, P.R. China, Department of Gynaecology and Obstetrics, Armed Police Hebei Corps Hospital, Shijiazhuang, Hebei 050081, P.R. China, Department of Pediatrics, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
Published online on: March 29, 2016 https://doi.org/10.3892/etm.2016.3199
Pages: 2221-2224
Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of this study was to investigate the effect of erythropoietin (EPO) on the inflammatory response and the mechanism analysis of the Τoll‑like receptor 4 (TLR4)/nuclear factor‑κB (NF‑κB) signaling pathway of NEC. A total of 94 patients with necrotizing enterocolitis (NEC) were randomly divided into the control (42 cases) and observation (52 cases) groups, The control group received the standard medical treatment plan, whereas for the observation group this treatment plan was combined with the application of recombinant EPO for intramuscular injection treatment. The clinical effect was subsequently compared. The results showed that the complication and death rates in the observation group were significantly lower than those in the control group with statistically significant differences (P<0.05). Following treatments, the levels of tumor necrosis factor‑α (TNF‑α) and interleukin (IL)‑6 in the observation group were significantly lower than those in the control group. The expression levels of mRNA of TLR4 and NF‑κB in the observation group were significantly lower than those in the control group, with statistically significant differences (P<0.05). In summary, EPO was able to reduce the levels of inflammatory response of TNF‑α and IL‑6 through the TLR4/NF‑κB signaling pathway, and improve the NEC, thus providing a basis for the clinical treatment of NEC.

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