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Article

Cardioprotective effect of notoginsenoside R1 in a rabbit lung remote ischemic postconditioning model via activation of the TGF‑β1/TAK1 signaling pathway

Retraction in: /10.3892/etm.2025.12793
  • Authors:
    • Zhi‑Ru Ge
    • Mao‑Chun Xu
    • Yu Huang
    • Chen‑Jun Zhang
    • Je Lin
    • Chang‑Wu Ruan
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Shanghai Pudong New Area Gongli Hospital, Shanghai 200135, P.R. China
  • Pages: 2341-2348
    |
    Published online on: April 4, 2016
       https://doi.org/10.3892/etm.2016.3222
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Abstract

Pharmacological postconditioning using cardioprotective agents is able to reduce myocardial infarct size. Notoginsenoside R1 (NG‑R1), a phytoestrogen isolated from Panax notoginseng saponins (PNS), is considered to have anti‑oxidative and anti‑apoptotic properties. However, its cardioprotective properties and underlying mechanisms remain largely unknown. The aim of the present study was to determine the cardioprotective and anti‑apoptotic effects of NG‑R1 in an ischemia‑reperfusion (IR)‑induced myocardial injury rabbit model. A total of 45 Japanese big‑ear rabbits were equally randomized to three groups: Control group, remote ischemic postconditioning (RIP) group and NG‑R1 intervention group. At the endpoint of the experiment, the animals were sacrificed to remove myocardial tissues for the detection of transforming growth factor (TGF)‑β1‑TGF‑β activated kinase 1 (TAK1) pathway‑related proteins by immunohistochemistry and western blot analysis, the activities of caspase‑3, ‑8 and ‑9 in myocardial cells by fluorometric assay, and the apoptosis of myocardial cells by terminal deoxynucleotidyl‑transferase‑mediated dUTP nick end labeling. Right and left lung tissues were stained with hematoxylin and eosin (H&E) to observe the severity of injury. NG‑R1 treatment reduced the activity of superoxide dismutase, increased the content of malondialdehyde, reduced the activities of caspase‑3, ‑8 and ‑9, and inhibited the apoptosis of myocardial cells in rabbits undergoing RIP. In addition, the expression of TGF‑β1‑TAK1 signaling pathway‑related proteins was downregulated following NG‑R1 intervention. H&E staining of bilateral lung tissues showed that cell morphology was generally intact without significant alveolar congestion, and there was no significant difference among the three groups. These results indicate that NG‑R1 protects the heart against IR injury, possibly by inhibiting the activation of the TGF‑β1‑TAK1 signaling pathway and attenuating apoptotic stress in the myocardium.
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1 

Bell RM and Yellon DM: There is more to life than revascularization: Therapeutic targeting of myocardial ischemia/reperfusion injury. Cardiovasc Ther. 29:e67–e79. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Smith CC and Yellon DM: Adipocytokines, cardiovascular pathophysiology and myocardial protection. Pharmacol Ther. 129:206–219. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Lecour S: Activation of the protective survivor activating factor enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway? J Mol Cell Cardiol. 47:32–40. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Matsumoto-Ida M, Takimoto Y, Aoyama T, Akao M, Takeda T and Kita T: Activation of TGF-beta1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats. Am J Physiol Heart Circ Physiol. 290:H709–H715. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Vanlangenakker N, Van den Berghe T, Bogaert P, Laukens B, Zobel K, Deshayes K, Vucic D, Fulda S, Vandenabeele P and Bertrand MJ: cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ. 18:656–665. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Omori E, Morioka S, Matsumoto K and Ninomiya-Tsuji J: TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity. J Biol Chem. 283:26161–26168. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Blanco S, Santos C and Lazo PA: Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. Mol Cell Biol. 27:7273–7283. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Kodym R, Kodym E and Story MD: Sequence-specific activation of TAK1-D by short double-stranded RNAs induces apoptosis in NCI-H460 cells. RNA. 14:535–542. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Goodman MD, Koch SE, Fuller-Bicer GA and Butler KL: Regulating RISK: A role for JAK-STAT signaling in postconditioning? Am J Physiol Heart Circ Physiol. 295:H1649–H1656. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Boengler K, Buechert A, Heinen Y, Roeskes C, Hilfiker-Kleiner D, Heusch G and Schulz R: Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice. Circ Res. 102:131–135. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Wang YQ MS and Le MZ: The protective effect of erythropoietin against myocardial ischemia-reperfusion injury in rats. J Med Postgra. 37:668–671. 2005.

12 

Lutgens E, Daemen MJ, de Muinck ED, Debets J, Leenders P and Smits JF: Chronic myocardial infarction in the mouse: Cardiac structural and functional changes. Cardiovasc Res. 41:586–593. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Dong TT, Cui XM, Song ZH, Zhao KJ, Ji ZN, Lo CK and Tsim KW: Chemical assessment of roots of Panax notoginseng in China: Regional and seasonal variations in its active constituents. J Agric Food Chem. 51:4617–4623. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Zhang HS and Wang SQ: Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway. Free Radic Biol Med. 40:1664–1674. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Zhang HS and Wang SQ: Notoginsenoside R1 from Panax notoginseng inhibits TNF-α-induced PAI-1 production in human aortic smooth muscle cells. Vascul Pharmcaol. 44:224–230. 2006. View Article : Google Scholar

16 

Grishin AV, Iavorovskiĭ AG, Zhidkov IL, Charchian ÉR, Ivanova AG, Paliulina MV and Sitnichenko NV: Sevoflurane optimal dosage estimation for myocardium pharmacological postconditioning: An experimental study. Anesteziol Reanimatol. 41–44. 2013.(In Russian). PubMed/NCBI

17 

McGrath JC, Drummond GB, McLachlan EM, Kilkenny C and Wainwright CL: Guidelines for reporting experiments involving animals: The ARRIVE guidelines. Br J Pharmacol. 160:1573–1576. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Styer AK, Sullivan BT, Puder M, Arsenault D, Petrozza JC, Serikawa T, Chang S, Hasan T, Gonzalez RR and Rueda BR: Ablation of leptin signaling disrupts the establishment, development and maintenance of endometriosis-like lesions in a murine model. Endocrinology. 149:506–514. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Hajrezaie M, Hassandarvish P, Moghadamtousi SZ, Gwaram NS, Golbabapour S, Najihussien A, Almagrami AA, Zahedifard M, Rouhollahi E, Karimian H, et al: Chemopreventive evaluation of a Schiff base derived copper (II) complex against azoxymethane-induced colorectal cancer in rats. PloS One. 9:e912462014. View Article : Google Scholar : PubMed/NCBI

20 

Draper HH, Squires EJ, Mahmoodi H, Wu J, Agarwal S and Hadley M: A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials. Free Radic Biol Med. 15:353–363. 1993. View Article : Google Scholar : PubMed/NCBI

21 

Sun Y, Oberley LW and Li Y: A simple method for clinical assay of superoxide dismutase. Clin Chem. 34:497–500. 1988.PubMed/NCBI

22 

Narula J, Kolodgie FD and Virmani R: Apoptosis and cardiomyopathy. Curr Opin Cardiol. 15:183–188. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Zhang WJ, Wojta J and Binder BR: Notoginsenoside R1 counteracts endotoxin-induced activation of endothelial cells in vitro and endotoxin-induced lethality in mice in vivo. Arterioscler Thromb Vasc Biol. 17:465–474. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Liu WJ, Tang HT, Jia YT, Ma B, Fu JF, Wang Y, Lv KY and Xia ZF: Notoginsenoside R1 attenuates renal ischemia-reperfusion injury in rats. Shock. 34:314–320. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Fadel E, Mazmanian GM, Chapelier A, Baudet B, Detruit H, de Montpreville V, Libert JM, Wartski M, Herve P and Dartevelle P: Lung reperfusion injury after chronic or acute unilateral pulmonary artery occlusion. Am J Respir Crit Care Med. 157:1294–1300. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Horgan MJ, Lum H and Malik AB: Pulmonary edema after pulmonary artery occlusion and reperfusion. Am Rev Respir Dis. 140:1421–1428. 1989. View Article : Google Scholar : PubMed/NCBI

27 

Wided K, Hassiba R and Mesbah L: Polyphenolic fraction of Algerian propolis reverses doxorubicin induced oxidative stress in liver cells and mitochondria. Pak J Pharm Sci. 27:1891–1897. 2014.PubMed/NCBI

28 

Chang G, Zhang D, Yu H, Zhang P, Wang Y, Zheng A and Qin S: Cardioprotective effects of exenatide against oxidative stress-induced injury. Int J Mol Med. 32:1011–1020. 2013.PubMed/NCBI

29 

Freudlsperger C, Bian Y, Contag Wise S, Burnett J, Coupar J, Yang X, Chen Z and Van Waes C: TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers. Oncogene. 32:1549–1559. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Arsura M, Panta GR, Bilyeu JD, Cavin LG, Sovak MA, Oliver AA, Factor V, Heuchel R, Mercurio F, Thorgeirsson SS and Sonenshein GE: Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: Implications in liver tumor formation. Oncogene. 22:412–425. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Li C, Qu X, Xu W, Qu N, Mei L, Liu Y, Wang X, Yu X, Liu Z, Nie D, et al: Arsenic trioxide induces cardiac fibroblast apoptosis in vitro and in vivo by up-regulating TGF-β1 expression. Toxicol Lett. 219:223–230. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Vivar R, Humeres C, Ayala P, Olmedo I, Catalán M, García L, Lavandero S and Díaz-Araya G: TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways. Biochim Biophys Acta. 1832:754–762. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Chen Z, Shen X, Shen F, Zhong W, Wu H, Liu S and Lai J: TAK1 activates AMPK-dependent cell death pathway in hydrogen peroxide-treated cardiomyocytes, inhibited by heat shock protein-70. Mol Cell Biochem. 377:35–44. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Freude B, Masters TN, Robicsek F, Fokin A, Kostin S, Zimmermann R, Ullmann C, Lorenz-Meyer S and Schaper J: Apoptosis is initiated by myocardial ischemia and executed during reperfusion. J Mol Cell Cardiol. 32:197–208. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Tramontano AF, Muniyappa R, Black AD, Blendea MC, Cohen I, Deng L, Sowers JR, Cutaia MV and El-Sherif N: Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway. Biochem Biophys Res Commun. 308:990–994. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Guo X, Chen KH, Guo Y, Liao H, Tang J and Xiao RP: Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway. Circ Res. 101:1113–1122. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Kim JK, Pedram A, Razandi M and Levin ER: Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms. J Biol Chem. 281:6760–6767. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Guo JW, Deng ZJ, Fu YH, Yang M, Ren B, Pan JQ and Liu RX: Effects of Panax notoginsenoside on TNF-alpha and MMP-2 expressions in rats with post-myocardial infarction ventricular remodeling and the mechanism. Nan Fang Yi Ke Da Xue Xue Bao. 29:2048–2050. 2009.(In Chinese). PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ge ZR, Xu MC, Huang Y, Zhang CJ, Lin J and Ruan CW: Cardioprotective effect of notoginsenoside R1 in a rabbit lung remote ischemic postconditioning model via activation of the TGF‑β1/TAK1 signaling pathway Retraction in /10.3892/etm.2025.12793. Exp Ther Med 11: 2341-2348, 2016.
APA
Ge, Z., Xu, M., Huang, Y., Zhang, C., Lin, J., & Ruan, C. (2016). Cardioprotective effect of notoginsenoside R1 in a rabbit lung remote ischemic postconditioning model via activation of the TGF‑β1/TAK1 signaling pathway Retraction in /10.3892/etm.2025.12793. Experimental and Therapeutic Medicine, 11, 2341-2348. https://doi.org/10.3892/etm.2016.3222
MLA
Ge, Z., Xu, M., Huang, Y., Zhang, C., Lin, J., Ruan, C."Cardioprotective effect of notoginsenoside R1 in a rabbit lung remote ischemic postconditioning model via activation of the TGF‑β1/TAK1 signaling pathway Retraction in /10.3892/etm.2025.12793". Experimental and Therapeutic Medicine 11.6 (2016): 2341-2348.
Chicago
Ge, Z., Xu, M., Huang, Y., Zhang, C., Lin, J., Ruan, C."Cardioprotective effect of notoginsenoside R1 in a rabbit lung remote ischemic postconditioning model via activation of the TGF‑β1/TAK1 signaling pathway Retraction in /10.3892/etm.2025.12793". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2341-2348. https://doi.org/10.3892/etm.2016.3222
Copy and paste a formatted citation
x
Spandidos Publications style
Ge ZR, Xu MC, Huang Y, Zhang CJ, Lin J and Ruan CW: Cardioprotective effect of notoginsenoside R1 in a rabbit lung remote ischemic postconditioning model via activation of the TGF‑β1/TAK1 signaling pathway Retraction in /10.3892/etm.2025.12793. Exp Ther Med 11: 2341-2348, 2016.
APA
Ge, Z., Xu, M., Huang, Y., Zhang, C., Lin, J., & Ruan, C. (2016). Cardioprotective effect of notoginsenoside R1 in a rabbit lung remote ischemic postconditioning model via activation of the TGF‑β1/TAK1 signaling pathway Retraction in /10.3892/etm.2025.12793. Experimental and Therapeutic Medicine, 11, 2341-2348. https://doi.org/10.3892/etm.2016.3222
MLA
Ge, Z., Xu, M., Huang, Y., Zhang, C., Lin, J., Ruan, C."Cardioprotective effect of notoginsenoside R1 in a rabbit lung remote ischemic postconditioning model via activation of the TGF‑β1/TAK1 signaling pathway Retraction in /10.3892/etm.2025.12793". Experimental and Therapeutic Medicine 11.6 (2016): 2341-2348.
Chicago
Ge, Z., Xu, M., Huang, Y., Zhang, C., Lin, J., Ruan, C."Cardioprotective effect of notoginsenoside R1 in a rabbit lung remote ischemic postconditioning model via activation of the TGF‑β1/TAK1 signaling pathway Retraction in /10.3892/etm.2025.12793". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2341-2348. https://doi.org/10.3892/etm.2016.3222
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