L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma

  • Authors:
    • Shanshan Bu
    • Fangfang Yuan
    • Xudong Wei
    • Qingsong Yin
    • Yufu Li
    • Ruihua Mi
    • Haiping Yang
    • Hongyi Li
    • Shoubei Ge
    • Yanyan Liu
    • Yongping Song
  • View Affiliations

  • Published online on: April 11, 2016     https://doi.org/10.3892/etm.2016.3249
  • Pages: 2437-2445
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Abstract

The aim of the present study was to compare the efficacy of an L‑asparaginase‑based regimen and a CHOP regimen followed by radiotherapy as first‑line treatments for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma (ENKTL). A total of 69 patients received the CHOP regimen as the first‑line treatment and 112 patients received the L‑asparaginase‑based regimen. All patients received radical radiotherapy following two cycles of chemotherapy. The overall response rates of the L‑asparaginase‑based and CHOP treatment groups were 90.18 and 72.46%, respectively (P=0.002). The one, two, and five‑year overall survival (OS) rates and progression‑free survival (PFS) rates of the L‑asparaginase group were 96.0, 88.3, 65.1, 94.2, 79.8 and 50.0%, respectively. The one, two, and five‑year OS and PFS rates of the CHOP group were 82.6, 61.9, 25.8, 63.8, 44.0 and 21.0%, respectively (P<0.001). Compared with CHOP treatment, L‑asparaginase‑based chemotherapy combined with radiotherapy was a safe and highly effective treatment for newly diagnosed ENKTL.
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June-2016
Volume 11 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Bu S, Yuan F, Wei X, Yin Q, Li Y, Mi R, Yang H, Li H, Ge S, Liu Y, Liu Y, et al: L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma. Exp Ther Med 11: 2437-2445, 2016
APA
Bu, S., Yuan, F., Wei, X., Yin, Q., Li, Y., Mi, R. ... Song, Y. (2016). L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma. Experimental and Therapeutic Medicine, 11, 2437-2445. https://doi.org/10.3892/etm.2016.3249
MLA
Bu, S., Yuan, F., Wei, X., Yin, Q., Li, Y., Mi, R., Yang, H., Li, H., Ge, S., Liu, Y., Song, Y."L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma". Experimental and Therapeutic Medicine 11.6 (2016): 2437-2445.
Chicago
Bu, S., Yuan, F., Wei, X., Yin, Q., Li, Y., Mi, R., Yang, H., Li, H., Ge, S., Liu, Y., Song, Y."L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2437-2445. https://doi.org/10.3892/etm.2016.3249