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Article

L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma

  • Authors:
    • Shanshan Bu
    • Fangfang Yuan
    • Xudong Wei
    • Qingsong Yin
    • Yufu Li
    • Ruihua Mi
    • Haiping Yang
    • Hongyi Li
    • Shoubei Ge
    • Yanyan Liu
    • Yongping Song
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Tumor Hospital of Zhengzhou University, Zhengzhou, Henan 450008, P.R. China, Department of Hematology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China, Department of Hematology, Xinzheng People's Hospital, Xinxiang, Henan 453000, P.R. China, Department of Hematology, Second Jiaozuo People's Hospital, Jiaozuo, Henan 522000, P.R. China
  • Pages: 2437-2445
    |
    Published online on: April 11, 2016
       https://doi.org/10.3892/etm.2016.3249
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Abstract

The aim of the present study was to compare the efficacy of an L‑asparaginase‑based regimen and a CHOP regimen followed by radiotherapy as first‑line treatments for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma (ENKTL). A total of 69 patients received the CHOP regimen as the first‑line treatment and 112 patients received the L‑asparaginase‑based regimen. All patients received radical radiotherapy following two cycles of chemotherapy. The overall response rates of the L‑asparaginase‑based and CHOP treatment groups were 90.18 and 72.46%, respectively (P=0.002). The one, two, and five‑year overall survival (OS) rates and progression‑free survival (PFS) rates of the L‑asparaginase group were 96.0, 88.3, 65.1, 94.2, 79.8 and 50.0%, respectively. The one, two, and five‑year OS and PFS rates of the CHOP group were 82.6, 61.9, 25.8, 63.8, 44.0 and 21.0%, respectively (P<0.001). Compared with CHOP treatment, L‑asparaginase‑based chemotherapy combined with radiotherapy was a safe and highly effective treatment for newly diagnosed ENKTL.
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Copy and paste a formatted citation
Spandidos Publications style
Bu S, Yuan F, Wei X, Yin Q, Li Y, Mi R, Yang H, Li H, Ge S, Liu Y, Liu Y, et al: L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma. Exp Ther Med 11: 2437-2445, 2016.
APA
Bu, S., Yuan, F., Wei, X., Yin, Q., Li, Y., Mi, R. ... Song, Y. (2016). L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma. Experimental and Therapeutic Medicine, 11, 2437-2445. https://doi.org/10.3892/etm.2016.3249
MLA
Bu, S., Yuan, F., Wei, X., Yin, Q., Li, Y., Mi, R., Yang, H., Li, H., Ge, S., Liu, Y., Song, Y."L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma". Experimental and Therapeutic Medicine 11.6 (2016): 2437-2445.
Chicago
Bu, S., Yuan, F., Wei, X., Yin, Q., Li, Y., Mi, R., Yang, H., Li, H., Ge, S., Liu, Y., Song, Y."L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2437-2445. https://doi.org/10.3892/etm.2016.3249
Copy and paste a formatted citation
x
Spandidos Publications style
Bu S, Yuan F, Wei X, Yin Q, Li Y, Mi R, Yang H, Li H, Ge S, Liu Y, Liu Y, et al: L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma. Exp Ther Med 11: 2437-2445, 2016.
APA
Bu, S., Yuan, F., Wei, X., Yin, Q., Li, Y., Mi, R. ... Song, Y. (2016). L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma. Experimental and Therapeutic Medicine, 11, 2437-2445. https://doi.org/10.3892/etm.2016.3249
MLA
Bu, S., Yuan, F., Wei, X., Yin, Q., Li, Y., Mi, R., Yang, H., Li, H., Ge, S., Liu, Y., Song, Y."L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma". Experimental and Therapeutic Medicine 11.6 (2016): 2437-2445.
Chicago
Bu, S., Yuan, F., Wei, X., Yin, Q., Li, Y., Mi, R., Yang, H., Li, H., Ge, S., Liu, Y., Song, Y."L‑asparaginase‑based regimen as a first‑line treatment for newly diagnosed nasal type extranodal natural killer cell/T‑cell lymphoma". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2437-2445. https://doi.org/10.3892/etm.2016.3249
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