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Circulating adiponectin levels and risk of endometrial cancer: Systematic review and meta‑analysis

  • Authors:
    • Zhi‑Jun Li
    • Xue‑Ling Yang
    • Yan Yao
    • Wei‑Qing Han
    • Bo Li
  • View Affiliations / Copyright

    Affiliations: Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Interventional Treatment, Cancer Hospital and Institution, Tianjin Medical University, Tianjin 300060, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2305-2313
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    Published online on: April 11, 2016
       https://doi.org/10.3892/etm.2016.3251
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Abstract

Previous epidemiological studies have presented conflicting results regarding associations between circulating adiponectin (APN) levels and the risk of endometrial cancer. Thus a meta‑analysis was performed to investigate the association between these factors. Multiple electronic sources, including PubMed, SpringerLink and Google Scholar databases were searched to identify relevant studies for the present meta‑analysis. All of the selected studies examined the correlation between circulating APN levels and endometrial cancer. The standardized mean difference (SMD) and 95% confidence intervals (CIs) were estimated and pooled using meta‑analysis methods. Overall, 18 case‑control studies met the inclusion criteria. A total of 5,692 participants and 2,337 cases of endometrial cancer were included in this meta‑analysis. The SMD of the pooled analysis (95% CI) were ‑1.96 (‑2.60, ‑1.31), P=0.000. When the cancer grades were compared, the APN values were not significantly different between the grades of endometrial cancer [G1 vs. G3, 1.02 (‑0.68, 2.72), P>0.05; G1 vs. G2, 0.34 (‑0.86, 1.54), P>0.05]. However, there was a significant association between high APN levels and postmenopausal endometrial cancer cases with an SMD (95% CI) of ‑2.27 (‑4.36, ‑0.18) and P<0.05, however, no association was observed in premenopausal endometrial cancer cases with an SMD (95% CI) of ‑1.52 (‑3.49, 0.45) and P>0.05. The low circulating APN level increases the risk of endometrial cancer, whereas the high APN level decreases this risk in postmenopausal women. Circulating APN as simple biomarkers may be a promising tool for the prevention, early diagnosis and disease monitoring of endometrial cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Li ZJ, Yang XL, Yao Y, Han WQ and Li B: Circulating adiponectin levels and risk of endometrial cancer: Systematic review and meta‑analysis. Exp Ther Med 11: 2305-2313, 2016.
APA
Li, Z., Yang, X., Yao, Y., Han, W., & Li, B. (2016). Circulating adiponectin levels and risk of endometrial cancer: Systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 11, 2305-2313. https://doi.org/10.3892/etm.2016.3251
MLA
Li, Z., Yang, X., Yao, Y., Han, W., Li, B."Circulating adiponectin levels and risk of endometrial cancer: Systematic review and meta‑analysis". Experimental and Therapeutic Medicine 11.6 (2016): 2305-2313.
Chicago
Li, Z., Yang, X., Yao, Y., Han, W., Li, B."Circulating adiponectin levels and risk of endometrial cancer: Systematic review and meta‑analysis". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2305-2313. https://doi.org/10.3892/etm.2016.3251
Copy and paste a formatted citation
x
Spandidos Publications style
Li ZJ, Yang XL, Yao Y, Han WQ and Li B: Circulating adiponectin levels and risk of endometrial cancer: Systematic review and meta‑analysis. Exp Ther Med 11: 2305-2313, 2016.
APA
Li, Z., Yang, X., Yao, Y., Han, W., & Li, B. (2016). Circulating adiponectin levels and risk of endometrial cancer: Systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 11, 2305-2313. https://doi.org/10.3892/etm.2016.3251
MLA
Li, Z., Yang, X., Yao, Y., Han, W., Li, B."Circulating adiponectin levels and risk of endometrial cancer: Systematic review and meta‑analysis". Experimental and Therapeutic Medicine 11.6 (2016): 2305-2313.
Chicago
Li, Z., Yang, X., Yao, Y., Han, W., Li, B."Circulating adiponectin levels and risk of endometrial cancer: Systematic review and meta‑analysis". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2305-2313. https://doi.org/10.3892/etm.2016.3251
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