Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2016 Volume 12 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2016 Volume 12 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Potential implications of interleukin-7 in chronic wound healing

  • Authors:
    • Annie Bartlett
    • Andrew J. Sanders
    • Fiona Ruge
    • Keith G. Harding
    • Wen G. Jiang
  • View Affiliations / Copyright

    Affiliations: Cardiff China Medical Research Collaborative (CCMRC), Cardiff University School of Medicine, Cardiff CF14 4XN, UK, Department of Wound Healing, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Copyright: © Bartlett et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 33-40
    |
    Published online on: April 18, 2016
       https://doi.org/10.3892/etm.2016.3263
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Methods of identifying chronic wounds that will heal in a timely, coordinated fashion and those that will not, together with novel therapeutic strategies, are vital for progression in the field of wound healing. Interleukin (IL)‑7 has been associated with various biological and pathological processes. The present study explored the potential role of IL‑7 in wound healing. IL-7 expression levels were examined in a clinical cohort of chronic wounds using reverse transcription-quantitative polymerase chain reaction and immunohistochemical staining analysis. The impact of recombinant human IL‑7 (rhIL-7) on the growth and migrational rates of HaCaT keratinocyte cells was subsequently examined using in vitro growth and electric cell‑substrate impedance sensing functional assays. The mRNA expression levels of IL‑7 were increased in the healed chronic wound tissue samples, compared with non‑healed chronic wound tissue samples, although the difference was not statistically significant. Similarly, immunohistochemical analysis revealed a greater staining intensity of IL‑7 in the healed chronic wound tissue sections compared with the non‑healed tissue sections. Treatment with rhIL‑7 did not affect HaCaT cell growth rates, but was shown to enhance cell migration, an effect that could be further enhanced through the addition of inhibitors of neuronal Wiskott‑Aldrich syndrome protein and protein kinase B. The data of the present study suggest that the expression levels of IL‑7 may be increased in healing chronic wounds, and thus IL‑7 may have a role in this process, potentially through its effects on the cellular migration of keratinocytes.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Behm B, Babilas P, Landthaler M and Schreml S: Cytokines, chemokines and growth factors in wound healing. J Eur Acad Dermatol Venereol. 26:812–820. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Werdin F, Tennenhaus M, Schaller HE and Rennekampff HO: Evidence-based management strategies for treatment of chronic wounds. Eplasty. 9:e192009.PubMed/NCBI

3 

Demidova-Rice TN, Hamblin MR and Herman IM: Acute and impaired wound healing: Pathophysiology and current methods for drug delivery, part 2: Role of growth factors in normal and pathological wound healing: Therapeutic potential and methods of delivery. Adv Skin Wound Care. 25:349–370. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Thomas DW and Harding KG: Wound healing. Br J Surg. 89:1203–1205. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Namen AE, Schmierer AE, March CJ, Overell RW, Park LS, Urdal DL and Mochizuki DY: B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors. J Exp Med. 167:988–1002. 1988. View Article : Google Scholar : PubMed/NCBI

6 

Heufler C, Topar G, Grasseger A, Stanzl U, Koch F, Romani N, Namen AE and Schuler G: Interleukin 7 is produced by murine and human keratinocytes. J Exp Med. 178:1109–1114. 1993. View Article : Google Scholar : PubMed/NCBI

7 

Goodwin RG, Lupton S, Schmierer A, Hjerrild KJ, Jerzy R, Clevenger W, Gillis S, Cosman D and Namen AE: Human interleukin 7: Molecular cloning and growth factor activity on human and murine B-lineage cells. Proc Natl Acad Sci USA. 86:302–306. 1989. View Article : Google Scholar : PubMed/NCBI

8 

Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D and Gillis S: Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 333:571–573. 1988. View Article : Google Scholar : PubMed/NCBI

9 

Sakata T, Iwagami S, Tsuruta Y, Teraoka H, Tatsumi Y, Kita Y, Nishikawa S, Takai Y and Fujiwara H: Constitutive expression of interleukin-7 mRNA and production of IL-7 by a cloned murine thymic stromal cell line. J Leukoc Biol. 48:205–212. 1990.PubMed/NCBI

10 

Watson JD, Morrissey PJ, Namen AE, Conlon PJ and Widmer MB: Effect of IL-7 on the growth of fetal thymocytes in culture. J Immunol. 143:1215–1222. 1989.PubMed/NCBI

11 

Murray R, Suda T, Wrighton N, Lee F and Zlotnik A: IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets. Int Immunol. 1:526–531. 1989. View Article : Google Scholar : PubMed/NCBI

12 

Wolf SS and Cohen A: Expression of cytokines and their receptors by human thymocytes and thymic stromal cells. Immunology. 77:362–368. 1992.PubMed/NCBI

13 

Grabstein KH, Namen AE, Shanebeck K, Voice RF, Reed SG and Widmer MB: Regulation of T cell proliferation by IL-7. J Immunol. 144:3015–3020. 1990.PubMed/NCBI

14 

Uckun FM, Tuel-Ahlgren L, Obuz V, Smith R, Dibirdik I, Hanson M, Langlie MC and Ledbetter JA: Interleukin 7 receptor engagement stimulates tyrosine phosphorylation, inositol phospholipid turnover, proliferation and selective differentiation to the CD4 lineage by human fetal thymocytes. Proc Natl Acad Sci USA. 88:6323–6327. 1991. View Article : Google Scholar : PubMed/NCBI

15 

Chazen GD, Pereira GM, LeGros G, Gillis S and Shevach EM: Interleukin 7 is a T-cell growth factor. Proc Natl Acad Sci USA. 86:5923–5927. 1989. View Article : Google Scholar : PubMed/NCBI

16 

Londei M, Verhoef A, Hawrylowicz C, Groves J, De Berardinis P and Feldmann M: Interleukin 7 is a growth factor for mature human T cells. Eur J Immunol. 20:425–428. 1990. View Article : Google Scholar : PubMed/NCBI

17 

Simonetta F, Gestermann N, Martinet KZ, Boniotto M, Tissières P, Seddon B and Bourgeois C: Interleukin-7 influences FOXP3+CD4+ regulatory T cells peripheral homeostasis. PloS One. 7:e365962012. View Article : Google Scholar : PubMed/NCBI

18 

Watanabe M, Ueno Y, Yajima T, Iwao Y, Tsuchiya M, Ishikawa H, Aiso S, Hibi T and Ishii H: Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J Clin Invest. 95:2945–2953. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Al-Rawi MA, Rmali K, Watkins G, Mansel RE and Jiang WG: Aberrant expression of interleukin-7 (IL-7) and its signalling complex in human breast cancer. Eur J Cancer. 40:494–502. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Dalloul A, Laroche L, Bagot M, Mossalayi MD, Fourcade C, Thacker DJ, Hogge DE, Merle-Béral H, Debré P and Schmitt C: Interleukin-7 is a growth factor for Sézary lymphoma cells. J Clin Invest. 90:1054–1060. 1992. View Article : Google Scholar : PubMed/NCBI

21 

Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ and Namen AE: Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily. Cell. 60:941–951. 1990. View Article : Google Scholar : PubMed/NCBI

22 

Ziegler SE, Morella KK, Anderson D, Kumaki N, Leonard WJ, Cosman D and Baumann H: Reconstitution of a functional interleukin (IL)-7 receptor demonstrates that the IL-2 receptor gamma chain is required for IL-7 signal transduction. Eur J Immunol. 25:399–404. 1995. View Article : Google Scholar : PubMed/NCBI

23 

Quentmeier H, Drexler HG, Fleckenstein D, Zaborski M, Armstrong A, Sims JE and Lyman SD: Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. Leukemia. 15:1286–1292. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Pandey A, Ozaki K, Baumann H, Levin SD, Puel A, Farr AG, Ziegler SF, Leonard WJ and Lodish HF: Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Nat Immunol. 1:59–64. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Kondo M, Takeshita T, Higuchi M, Nakamura M, Sudo T, Nishikawa S and Sugamura K: Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Science. 263:1453–1454. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK and Paul WE: Interleukin-2 receptor gamma chain: A functional component of the interleukin-4 receptor. Science. 262:1880–1883. 1993. View Article : Google Scholar : PubMed/NCBI

27 

Kimura Y, Takeshita T, Kondo M, Ishii N, Nakamura M, Van Snick J and Sugamura K: Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex. Int Immunol. 7:115–120. 1995. View Article : Google Scholar : PubMed/NCBI

28 

Anderson DM, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, Giri J, Copeland NG, Gilbert DJ and Jenkins NA: Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J Biol Chem. 270:29862–29869. 1995. View Article : Google Scholar : PubMed/NCBI

29 

Dus D, Krawczenko A, Załecki P, Paprocka M, Wiedłocha A, Goupille C and Kieda C: IL-7 receptor is present on human microvascular endothelial cells. Immunol Lett. 86:163–168. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Cosenza L, Gorgun G, Urbano A and Foss F: Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines. Cell Signal. 14:317–325. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Foxwell BM, Beadling C, Guschin D, Kerr I and Cantrell D: Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells. Eur J Immunol. 25:3041–3046. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Pallard C, Stegmann AP, van Kleffens T, Smart F, Venkitaraman A and Spits H: Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. Immunity. 10:525–535. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Mazzucchelli R and Durum SK: Interleukin-7 receptor expression: Intelligent design. Nat Rev Immunol. 7:144–154. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Li WQ, Jiang Q, Khaled AR, Keller JR and Durum SK: Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival. J Biol Chem. 279:29160–29166. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Dadi HK and Roifman CM: Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor on human thymocytes. J Clin Invest. 92:1559–1563. 1993. View Article : Google Scholar : PubMed/NCBI

36 

Rich BE, Campos-Torres J, Tepper RI, Moreadith RW and Leder P: Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice. J Exp Med. 177:305–316. 1993. View Article : Google Scholar : PubMed/NCBI

37 

Touw I, Pouwels K, van Agthoven T, van Gurp R, Budel L, Hoogerbrugge H, Delwel R, Goodwin R, Namen A and Löwenberg B: Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemia. Blood. 75:2097–2101. 1990.PubMed/NCBI

38 

Eder M, Ottmann OG, Hansen-Hagge TE, Bartram CR, Gillis S, Hoelzer D and Ganser A: Effects of recombinant human IL-7 on blast cell proliferation in acute lymphoblastic leukemia. Leukemia. 4:533–540. 1990.PubMed/NCBI

39 

Sasson SC, Smith S, Seddiki N, Zaunders JJ, Bryant A, Koelsch KK, Weatherall C, Munier ML, McGinley C, Yeung J, et al: IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markers. Cytokine. 50:58–68. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Foss FM, Koc Y, Stetler-Stevenson MA, Nguyen DT, O'Brien MC, Turner R and Sausville EA: Costimulation of cutaneous T-cell lymphoma cells by interleukin-7 and interleukin-2: Potential autocrine or paracrine effectors in the Sézary syndrome. J Clin Oncol. 12:326–335. 1994.PubMed/NCBI

41 

Qin JZ, Zhang CL, Kamarashev J, Dummer R, Burg G and Dobbeling U: Interleukin-7 and interleukin-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T-cell lymphoma cells. Blood. 98:2778–2783. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Foss HD, Hummel M, Gottstein S, Ziemann K, Falini B, Herbst H and Stein H: Frequent expression of IL-7 gene transcripts in tumor cells of classical Hodgkin's disease. Am J Pathol. 146:33–39. 1995.PubMed/NCBI

43 

Digel W, Schmid M, Heil G, Conrad P, Gillis S and Porzsolt F: Human interleukin-7 induces proliferation of neoplastic cells from chronic lymphocytic leukemia and acute leukemias. Blood. 78:753–759. 1991.PubMed/NCBI

44 

Yoshioka R, Shimizu S, Tachibana J, Hirose Y, Fukutoku M, Takeuchi Y, Sugai S, Takiguchi T and Konda S: Interleukin-7 (IL-7)-induced proliferation of CD8+ T-chronic lymphocytic leukemia cells. J Clin Immunol. 12:101–106. 1992. View Article : Google Scholar : PubMed/NCBI

45 

Takeuchi T, Yamanouchi H, Yue Q and Ohtsuki Y: Epithelial component of lymphoid stroma-rich Warthin's tumour expresses interleukin (IL)-7. Histopathology. 32:383–384. 1998. View Article : Google Scholar : PubMed/NCBI

46 

Paleri V, Pulimood A, Davies GR and Birchall MA: Interleukins 7 and 12 are expressed in head and neck squamous cancer. Clin Otolaryngol Allied Sci. 26:302–306. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Trinder P, Seitzer U, Gerdes J, Seliger B and Maeurer M: Constitutive and IFN-gamma regulated expression of IL-7 and IL-15 in human renal cell cancer. Int J Oncol. 14:23–31. 1999.PubMed/NCBI

48 

Oka M, Hirose K, Iizuka N, Aoyagi K, Yamamoto K, Abe T, Hazama S and Suzuki T: Cytokine mRNA expression patterns in human esophageal cancer cell lines. J Interferon Cytokine Res. 15:1005–1009. 1995. View Article : Google Scholar : PubMed/NCBI

49 

Maeurer MJ, Walter W, Martin D, Zitvogel L, Elder E, Storkus W and Lotze MT: Interleukin-7 (IL-7) in colorectal cancer: IL-7 is produced by tissues from colorectal cancer and promotes preferential expansion of tumour infiltrating lymphocytes. Scand J Immunol. 45:182–192. 1997. View Article : Google Scholar : PubMed/NCBI

50 

Al-Rawi MA, Rmali K, Mansel RE and Jiang WG: Interleukin 7 induces the growth of breast cancer cells through a wortmannin-sensitive pathway. Br J Surg. 91:61–68. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Al-Rawi MA, Watkins G, Mansel RE and Jiang WG: The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells. Int J Oncol. 27:721–730. 2005.PubMed/NCBI

52 

Al-Rawi MA, Watkins G, Mansel RE and Jiang WG: Interleukin 7 upregulates vascular endothelial growth factor D in breast cancer cells and induces lymphangiogenesis in vivo. Br J Surg. 92:305–310. 2005. View Article : Google Scholar : PubMed/NCBI

53 

Ming J, Zhang Q, Qiu X and Wang E: Interleukin 7/interleukin 7 receptor induce c-Fos/c-Jun-dependent vascular endothelial growth factor-D up-regulation: A mechanism of lymphangiogenesis in lung cancer. Eur J Cancer. 45:866–873. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Ming J, Zhang Q, Jiang Y, Qiu X and Bai X: The expressions of IL-7 and IL-7R and the relationship between them with lymph node metastasis and prognosis in non-small cell lung cancer. Zhongguo Fei Ai Za Zhi. 13:1101–1106. 2010.(In Chinese). PubMed/NCBI

55 

Ming J, Jiang G, Zhang Q, Qiu X and Wang E: Interleukin-7 up-regulates cyclin D1 via activator protein-1 to promote proliferation of cell in lung cancer. Cancer Immunol Immunother. 61:79–88. 2012. View Article : Google Scholar : PubMed/NCBI

56 

Matsue H, Bergstresser PR and Takashima A: Keratinocyte-derived IL-7 serves as a growth factor for dendritic epidermal T cells in mice. J Immunol. 151:6012–6019. 1993.PubMed/NCBI

57 

Takashima A, Matsue H, Bergstresser PR and Ariizumi K: Interleukin-7-dependent interaction of dendritic epidermal T cells with keratinocytes. J Invest Dermatol. 105(1 Suppl): 50S–53S. 1995. View Article : Google Scholar : PubMed/NCBI

58 

Giacalone B, D'Auria L, Bonifati C, Ferraro C, Riccardi E, Mussi A, D'Agosto G, Cordiali-Fei P and Ameglio F: Decreased interleukin-7 and transforming growth factor-beta1 levels in blister fluids as compared to the respective serum levels in patients with bullous pemphigoid. Opposite behavior of TNF-alpha, interleukin-4 and interleukin-10. Exp Dermatol. 7:157–161. 1998. View Article : Google Scholar : PubMed/NCBI

59 

Balkwill F and Mantovani A: Inflammation and cancer: Back to Virchow? Lancet. 357:539–545. 2001. View Article : Google Scholar : PubMed/NCBI

60 

Dvorak HF: Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med. 315:1650–1659. 1986. View Article : Google Scholar : PubMed/NCBI

61 

Bosanquet DC, Harding KG, Ruge F, Sanders AJ and Jiang WG: Expression of IL-24 and IL-24 receptors in human wound tissues and the biological implications of IL-24 on keratinocytes. Wound Repair Regen. 20:896–903. 2012. View Article : Google Scholar : PubMed/NCBI

62 

Jiang WG, Sanders AJ, Ruge F and Harding KG: Influence of interleukin-8 (IL-8) and IL-8 receptors on the migration of human keratinocytes, the role of PLC-γ and potential clinical implications. Exp Ther Med. 3:231–236. 2012.PubMed/NCBI

63 

Jiang WG, Martin TA, Lewis-Russell JM, Douglas-Jones A, Ye L and Mansel RE: Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome. Mol Cancer. 7:712008. View Article : Google Scholar : PubMed/NCBI

64 

Palagummi S, Harbison S and Fleming R: A time-course analysis of mRNA expression during injury healing in human dermal injuries. Int J Legal Med. 128:403–414. 2014. View Article : Google Scholar : PubMed/NCBI

65 

Kandel ES and Hay N: The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res. 253:210–229. 1999. View Article : Google Scholar : PubMed/NCBI

66 

Grille SJ, Bellacosa A, Upson J, Klein-Szanto AJ, van Roy F, Lee-Kwon W, Donowitz M, Tsichlis PN and Larue L: The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res. 63:2172–2178. 2003.PubMed/NCBI

67 

Barata JT, Silva A, Brandao JG, Nadler LM, Cardoso AA and Boussiotis VA: Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use and growth of T cell acute lymphoblastic leukemia cells. J Exp Med. 200:659–669. 2004. View Article : Google Scholar : PubMed/NCBI

68 

Ramesh N, Antón IM, Martínez-Quiles N and Geha RS: Waltzing with WASp. Trends Cell Biol. 9:15–19. 1999. View Article : Google Scholar : PubMed/NCBI

69 

Miki H, Miura K and Takenawa T: N-WASp, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J. 15:5326–5335. 1996.PubMed/NCBI

70 

Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T and Kirschner MW: The interaction between N-WASp and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 97:221–231. 1999. View Article : Google Scholar : PubMed/NCBI

71 

Rajput C, Kini V, Smith M, Yazbeck P, Chavez A, Schmidt T, Zhang W, Knezevic N, Komarova Y and Mehta D: Neural Wiskott-Aldrich syndrome protein (N-WASp)-mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions. J Biol Chem. 288:4241–4250. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Bartlett A, Sanders AJ, Ruge F, Harding KG and Jiang WG: Potential implications of interleukin-7 in chronic wound healing. Exp Ther Med 12: 33-40, 2016.
APA
Bartlett, A., Sanders, A.J., Ruge, F., Harding, K.G., & Jiang, W.G. (2016). Potential implications of interleukin-7 in chronic wound healing. Experimental and Therapeutic Medicine, 12, 33-40. https://doi.org/10.3892/etm.2016.3263
MLA
Bartlett, A., Sanders, A. J., Ruge, F., Harding, K. G., Jiang, W. G."Potential implications of interleukin-7 in chronic wound healing". Experimental and Therapeutic Medicine 12.1 (2016): 33-40.
Chicago
Bartlett, A., Sanders, A. J., Ruge, F., Harding, K. G., Jiang, W. G."Potential implications of interleukin-7 in chronic wound healing". Experimental and Therapeutic Medicine 12, no. 1 (2016): 33-40. https://doi.org/10.3892/etm.2016.3263
Copy and paste a formatted citation
x
Spandidos Publications style
Bartlett A, Sanders AJ, Ruge F, Harding KG and Jiang WG: Potential implications of interleukin-7 in chronic wound healing. Exp Ther Med 12: 33-40, 2016.
APA
Bartlett, A., Sanders, A.J., Ruge, F., Harding, K.G., & Jiang, W.G. (2016). Potential implications of interleukin-7 in chronic wound healing. Experimental and Therapeutic Medicine, 12, 33-40. https://doi.org/10.3892/etm.2016.3263
MLA
Bartlett, A., Sanders, A. J., Ruge, F., Harding, K. G., Jiang, W. G."Potential implications of interleukin-7 in chronic wound healing". Experimental and Therapeutic Medicine 12.1 (2016): 33-40.
Chicago
Bartlett, A., Sanders, A. J., Ruge, F., Harding, K. G., Jiang, W. G."Potential implications of interleukin-7 in chronic wound healing". Experimental and Therapeutic Medicine 12, no. 1 (2016): 33-40. https://doi.org/10.3892/etm.2016.3263
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team