Open Access

Optic nerve involvement in immunoglobulin G4‑related disease: A case report

  • Authors:
    • Weihe Zhang
    • Jie Luo
    • Jinsong Jiao
  • View Affiliations

  • Published online on: April 26, 2016     https://doi.org/10.3892/etm.2016.3291
  • Pages: 111-114
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study reports the case of a 79‑year‑old woman manifesting skin changes, a pancreatic neoplasm, enlarged lymph nodes, an eyelid mass and interstitial pneumonia over a 30‑year period. At 2 months before admission to our hospital, the patient presented rapid vision loss in the left eye. Left optic nerve atrophy with a focal hyperintense lesion was documented on a T2‑weighted magnetic resonance imaging (MRI) scan, and visual evoked potential implicit times were prolonged. Elevated serum immunoglobulin G4 (IgG4) concentrations and the presence of enriched IgG4‑positive plasma cells in the lymph nodes established the diagnosis of IgG4‑related optic neuropathy. Following oral treatment with methylprednisolone, the serum IgG4 levels fell to normal levels, and the left eye visual acuity improved to a level that remained stable over a 1‑year follow‑up period. After 4 months of methylprednisolone administration, the optic nerve appeared to be normal on an MRI scan. Prior reports on IgG4‑related optic neuropathy involved an infiltrating mass, which was not observed in the present case. Similarly to the current study, previous cases have responded to treatment with glucocorticoids, indicating that the underlying mechanism of the disease may be common.
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July-2016
Volume 12 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang W, Luo J and Jiao J: Optic nerve involvement in immunoglobulin G4‑related disease: A case report. Exp Ther Med 12: 111-114, 2016.
APA
Zhang, W., Luo, J., & Jiao, J. (2016). Optic nerve involvement in immunoglobulin G4‑related disease: A case report. Experimental and Therapeutic Medicine, 12, 111-114. https://doi.org/10.3892/etm.2016.3291
MLA
Zhang, W., Luo, J., Jiao, J."Optic nerve involvement in immunoglobulin G4‑related disease: A case report". Experimental and Therapeutic Medicine 12.1 (2016): 111-114.
Chicago
Zhang, W., Luo, J., Jiao, J."Optic nerve involvement in immunoglobulin G4‑related disease: A case report". Experimental and Therapeutic Medicine 12, no. 1 (2016): 111-114. https://doi.org/10.3892/etm.2016.3291