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Article Open Access

Candesartan cilexetil prevents diet‑induced insulin resistance via peroxisome proliferator‑activated receptor‑γ activation in an obese rat model

  • Authors:
    • Wen‑Hua Yan
    • Chang‑Yu Pan
    • Jing‑Tao Dou
    • Jun‑Hua Meng
    • Bao‑An Wang
    • Yi‑Ming Mu
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 272-278
    |
    Published online on: April 27, 2016
       https://doi.org/10.3892/etm.2016.3297
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Abstract

Angiotensin II type 1 receptor (AT1R) blockers (ARBs) have been shown to reduce the incidence of type 2 diabetes mellitus; however, the underlying molecular mechanism is unknown. Peroxisome proliferator‑activated receptor γ (PPARγ) is the central regulator of insulin and glucose metabolism, which improves insulin sensitivity. Whether candesartan cilexetil, as a prodrug of the AT1R blocker candesartan, has PPARγ‑activating properties remains to be elucidated. The aim of the present study was to investigate the effects of oral administration of candesartan cilexetil on glucose tolerance and the actions of PPARγ on liver and adipose tissue in the insulin‑resistant obese rat induced by high‑fat diet. Animals treated with candesartan cilexetil showed an improved glucose tolerance after oral glucose challenge. Whole‑body insulin sensitivity was evaluated using the hyperinsulinemic‑euglycemic clamp technique. During high‑fat feeding in high‑fat diet (HF) rats, the glucose infusion rate (GIR) was 52.3% lower than that in normal chow (NC) rats. However, the GIR was significantly enhanced following candesartan cilexetil treatment. Angiotensin II receptor antagonism also resulted in significant increases in PPARγ protein expression in adipose and liver tissue. These results indicate that PPARγ activation by candesartan cilexetil may provide novel therapeutic options in the treatment of patients with metabolic syndrome.
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Copy and paste a formatted citation
Spandidos Publications style
Yan WH, Pan CY, Dou JT, Meng JH, Wang BA and Mu YM: Candesartan cilexetil prevents diet‑induced insulin resistance via peroxisome proliferator‑activated receptor‑γ activation in an obese rat model. Exp Ther Med 12: 272-278, 2016.
APA
Yan, W., Pan, C., Dou, J., Meng, J., Wang, B., & Mu, Y. (2016). Candesartan cilexetil prevents diet‑induced insulin resistance via peroxisome proliferator‑activated receptor‑γ activation in an obese rat model. Experimental and Therapeutic Medicine, 12, 272-278. https://doi.org/10.3892/etm.2016.3297
MLA
Yan, W., Pan, C., Dou, J., Meng, J., Wang, B., Mu, Y."Candesartan cilexetil prevents diet‑induced insulin resistance via peroxisome proliferator‑activated receptor‑γ activation in an obese rat model". Experimental and Therapeutic Medicine 12.1 (2016): 272-278.
Chicago
Yan, W., Pan, C., Dou, J., Meng, J., Wang, B., Mu, Y."Candesartan cilexetil prevents diet‑induced insulin resistance via peroxisome proliferator‑activated receptor‑γ activation in an obese rat model". Experimental and Therapeutic Medicine 12, no. 1 (2016): 272-278. https://doi.org/10.3892/etm.2016.3297
Copy and paste a formatted citation
x
Spandidos Publications style
Yan WH, Pan CY, Dou JT, Meng JH, Wang BA and Mu YM: Candesartan cilexetil prevents diet‑induced insulin resistance via peroxisome proliferator‑activated receptor‑γ activation in an obese rat model. Exp Ther Med 12: 272-278, 2016.
APA
Yan, W., Pan, C., Dou, J., Meng, J., Wang, B., & Mu, Y. (2016). Candesartan cilexetil prevents diet‑induced insulin resistance via peroxisome proliferator‑activated receptor‑γ activation in an obese rat model. Experimental and Therapeutic Medicine, 12, 272-278. https://doi.org/10.3892/etm.2016.3297
MLA
Yan, W., Pan, C., Dou, J., Meng, J., Wang, B., Mu, Y."Candesartan cilexetil prevents diet‑induced insulin resistance via peroxisome proliferator‑activated receptor‑γ activation in an obese rat model". Experimental and Therapeutic Medicine 12.1 (2016): 272-278.
Chicago
Yan, W., Pan, C., Dou, J., Meng, J., Wang, B., Mu, Y."Candesartan cilexetil prevents diet‑induced insulin resistance via peroxisome proliferator‑activated receptor‑γ activation in an obese rat model". Experimental and Therapeutic Medicine 12, no. 1 (2016): 272-278. https://doi.org/10.3892/etm.2016.3297
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