Open Access

Remission of late-onset post-heart transplantation lymphoproliferative disorder following treatment with rituximab and modified mini-CHOP chemotherapy: A case report

  • Authors:
    • Qiang Huang
    • Tianxin Yang
    • Xing Jin
    • Xuming Ni
    • Haiyan Qi
    • Zhikun Yan
  • View Affiliations

  • Published online on: May 5, 2016     https://doi.org/10.3892/etm.2016.3310
  • Pages: 262-266
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Post-transplant lymphoproliferative disorder (PTLD) is one of the most frequent secondary malignancies that can follow immunosuppressive therapy for solid organ transplantation, and may result in severe morbidities and even mortality. A middle‑aged Han Chinese patient, prescribed with immunosuppressive cyclosporine and prednisone, developed PTLD that manifested as a painless cervical lymph node enlargement, 12 years following heart transplantation. Histology revealed monomorphic B‑cell PTLD (diffuse large-cell lymphoma); as a result the immunosuppressive regimen of the patient was changed to tacrolimus and mycophenolate mofetil. In addition, the patient was changed to 6‑cycle rituximab with a modified mini‑CHOP (R‑mini‑CHOP) regimen for induction, and 8‑cycle quarterly rituximab treatment and maintenance therapy. R‑mini‑CHOP therapy was well tolerated, and no allograft rejection occurred. The patient exhibited clinical remission as demonstrated by the results of the positron emission tomography‑computed tomography at the 5-year follow-up visit following R‑mini‑CHOP therapy. In conclusion, R‑mini‑CHOP therapy following reduced immunosuppression is effective and safe for the treatment of late-onset PTLD following heart transplantation.
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July-2016
Volume 12 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Huang Q, Yang T, Jin X, Ni X, Qi H and Yan Z: Remission of late-onset post-heart transplantation lymphoproliferative disorder following treatment with rituximab and modified mini-CHOP chemotherapy: A case report. Exp Ther Med 12: 262-266, 2016
APA
Huang, Q., Yang, T., Jin, X., Ni, X., Qi, H., & Yan, Z. (2016). Remission of late-onset post-heart transplantation lymphoproliferative disorder following treatment with rituximab and modified mini-CHOP chemotherapy: A case report. Experimental and Therapeutic Medicine, 12, 262-266. https://doi.org/10.3892/etm.2016.3310
MLA
Huang, Q., Yang, T., Jin, X., Ni, X., Qi, H., Yan, Z."Remission of late-onset post-heart transplantation lymphoproliferative disorder following treatment with rituximab and modified mini-CHOP chemotherapy: A case report". Experimental and Therapeutic Medicine 12.1 (2016): 262-266.
Chicago
Huang, Q., Yang, T., Jin, X., Ni, X., Qi, H., Yan, Z."Remission of late-onset post-heart transplantation lymphoproliferative disorder following treatment with rituximab and modified mini-CHOP chemotherapy: A case report". Experimental and Therapeutic Medicine 12, no. 1 (2016): 262-266. https://doi.org/10.3892/etm.2016.3310