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Antiseptic effect of sea cucumber (Holothuria atra) against multi-organ failure induced by sepsis: Molecular and histopathological study

  • Authors:
    • Dalia Y. Saad
    • Ahmed A. Baiomy
    • Ahmed A. Mansour
  • View Affiliations / Copyright

    Affiliations: Department of Zoology, Faculty of Science, Cairo University, Giza 12613, Egypt, Medical Biotechnology, Faculty of Applied Medical Sciences, Taif University, Taif 11942, Saudi Arabia
    Copyright: © Saad et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 222-230
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    Published online on: May 10, 2016
       https://doi.org/10.3892/etm.2016.3321
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Abstract

Sepsis is a systemic inflammatory response to infection and severe sepsis patients can develop acute lung and liver injury. The aim of the present study was to evaluate the efficacy of Holothuria atra methanolic body wall extract (HaE), as an antioxidant and anti‑inflammatory agent against induced sepsis in a cecal ligation and puncture (CLP) rat model. In total, 30 males albino rats were divided into three groups (n=10 each) as follows: Sham (Sh), which was used as negative control; sepsis (Se), which was used as a positive control and was subjected to CLP surgery; and Ho, which was subjected to CLP and fed with 200 mg/kg (body weight) of HaE, once daily for 7 days. Subsequently, the expression of various genes was detected by polymerase chain reaction, while liver and lung tissues were examined by immunohistochemistry. The expression of Caspase‑3 was significantly reduced in liver and lung tissues in the Ho group, while the expression levels of Gsta2, Cat and Sod1 genes were slightly reduced in the Ho group, when compared with the Se group. In addition, expression levels of tumor necrosis factor, interferon‑γ, liver interleukin (IL)1b and lung IL1a were reduced in the Ho group compared with the Se group. Furthermore, histopathological changes were observed in liver tissues of the Se group, including congestion of hepatoportal blood vessel and focal hepatic necrosis, while lung tissues showed marked edema, hemorrhage and alveolar septal thickening. The Ho group showed apparent normal hepatic parenchyma and slight interstitial pneumonia. Immunohistochemical staining of caspase‑3 in liver and lung tissues showed no expression in the Sh group, strong expression in the Se group and moderate expression in the Ho group. In conclusion, HaE demonstrated beneficial effect against induced sepsis, which may be attributed to its antioxidant and antiapoptotic activities.
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1 

Raoofi R, Salmani Z, Moradi F, Sotoodeh A and Sobhanian S: Procalcitonin as a marker for early diagnosis of sepsis. Am J Infect Dis. 10:15–20. 2014. View Article : Google Scholar

2 

Ma N, Xing C, Xiao H, Wang Y, Wang K, Hou C, Han G, Chen G, Marrero B, Wang Y, et al: C5a regulates Il-12+ DC migration to induce pathogenic Th1 and Th17 cells in sepsis. PLoS One. 8:e697792013. View Article : Google Scholar : PubMed/NCBI

3 

Galley HF: Oxidative stress and mitochondrial dysfunction in sepsis. Br J Anaesth. 107:57–64. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Abuşoğlu S, Onur EÇelik Ht, Güvenç Y, Sakarya M, Sakarya A, Var A and Uyanik BS: The effect of lidocaine on liver tissue lipid peroxide levels in septic rat model. Int J Mevlana Med Sci. 1:31–34. 2013.

5 

Mansour AA, Salam MA and Saad YM: Mice (Mus musculus) genome responses to methotrexate (MTX) and some plant extracts. Life Sci J. 9:4881–4886. 2012.

6 

Bergquist M, Nurkkala M, Rylander C, Kristiansson E, Hedenstierna G and Lindholm C: Expression of the glucocorticoid receptor is decreased in experimental Staphylococcus aureus sepsis. J Infect. 67:574–583. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Hill AL, Lowes DA, Webster NR, Sheth CC, Gow NA and Galley HF: Regulation of pentraxin-3 by antioxidants. Br J Anaesth. 103:833–839. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Nesseler N, Launey Y, Aninat C, Morel F, Mallédant Y and Seguin P: Clinical review: The liver in sepsis. Crit Care. 16:2352012. View Article : Google Scholar : PubMed/NCBI

9 

Ozturk E, Demirbilek S, Begec Z, Surucu M, Fadillioglu E, Kirimlioglu H and Ersoy MO: Does leflunomide attenuate the sepsis-induced acute lung injury? Pediatr Surg Int. 24:899–905. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Ates I, Dogan N, Aksoy M, Halıcı Z, Gündogdu C and Keles MS: The protective effects of IgM-enriched immunoglobulin and erythropoietin on the lung and small intestine tissues of rats with induced sepsis: Biochemical and histopathological evaluation. Pharm Biol. 53:78–84. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Edelman DA, Jiang Y, Tyburski JG, Wilson RF and Steffes CP: Cytokine production in lipopolysaccharide-exposed rat lung pericytes. J Trauma. 62:89–93. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Spooner CE, Markowitz NP and Saravolatz LD: The role of tumor necrosis factor in sepsis. Clin Immunol Immunopathol. 62:S11–S17. 1992. View Article : Google Scholar : PubMed/NCBI

13 

Suk K, Chang I, Kim YH, Kim S, Kim JY, Kim H and Lee MS: Interferon gamma (IFNgamma) and tumor necrosis factor alpha synergism in ME-180 cervical cancer cell apoptosis and necrosis. IFNgamma inhibits cytoprotective NF-kappa B through STAT1/IRF-1 pathways. J Biol Chem. 276:13153–13159. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Price G, Brenner MK, Prentice HG, Hoffbrand AV and Newland AC: Cytotoxic effects of tumour necrosis factor and gamma-interferon on acute myeloid leukaemia blasts. Br J Cancer. 55:287–290. 1987. View Article : Google Scholar : PubMed/NCBI

15 

Pasparakis M, Alexopoulou L, Episkopou V and Kollias G: Immune and inflammatory responses in TNF alpha-deficient mice: A critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers and in the maturation of the humoral immune response. J Exp Med. 184:1397–1411. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Rothe J, Lesslauer W, Lötscher H, Lang Y, Koebel P, Althage A, Zinkernagel R, Steinmetz M, Bluethmann H and Köntgen F: Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature. 364:798–802. 1993. View Article : Google Scholar : PubMed/NCBI

17 

Lv S, Han M, Yi R, Kwon S, Dai C and Wang R: Anti-TNF-α therapy for patients with sepsis: A systematic meta-analysis. Int J Clin Pract. 68:520–528. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Doherty DE and Worthen GS: Lipopolysaccharide-induced monocyte retention in the lungs of rabbits. Role of cell stiffness and the CD11/CD18 leukocyte adhesion complex. Chest. 105(3 Suppl): 108S1994. View Article : Google Scholar : PubMed/NCBI

19 

Silva AT and Cohen J: Role of interferon-gamma in experimental gram-negative sepsis. J Infect Dis. 166:331–335. 1992. View Article : Google Scholar : PubMed/NCBI

20 

Car BD, Eng VM, Schnyder B, Ozmen L, Huang S, Gallay P, Heumann D, Aguet M and Ryffel B: Interferon gamma receptor deficient mice are resistant to endotoxic shock. J Exp Med. 179:1437–1444. 1994. View Article : Google Scholar : PubMed/NCBI

21 

Heinzel FP: The role of IFN-gamma in the pathology of experimental endotoxemia. J Immunol. 145:2920–2924. 1990.PubMed/NCBI

22 

Boehm U, Klamp T, Groot M and Howard JC: Cellular responses to interferon-gamma. Annu Rev Immunol. 15:749–795. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Shtrichman R and Samuel CE: The role of gamma interferon in antimicrobial immunity. Curr Opin Microbiol. 4:251–259. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Heremans H, Van Damme J, Dillen C, Dijkmans R and Billiau A: Interferon gamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice. J Exp Med. 171:1853–1869. 1990. View Article : Google Scholar : PubMed/NCBI

25 

Bosisio D, Polentarutti N, Sironi M, Bernasconi S, Miyake K, Webb GR, Martin MU, Mantovani A and Muzio M: Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: A molecular basis for priming and synergism with bacterial lipopolysaccharide. Blood. 99:3427–3431. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Adib-Conquy M and Cavaillon JM: Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression. J Biol Chem. 277:27927–27934. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Ridzwan BH, Kaswandi MA, Azman Y and Fuad M: Screening for antibacterial agents in three species of sea cucumbers from coastal areas of Sabah. Gen Pharmacol. 26:1539–1543. 1995. View Article : Google Scholar : PubMed/NCBI

28 

Selva Prabhu A, Ananthan G, Mohamed Hussain HS and Balasubramanian T: Antibacterial activity of Ascidian phallusia arabica against human clinical isolates. J Appl Pharmaceutical Sci. 1:143–145. 2011.

29 

Sohair F, Mahmoud AA and Mohannad H: Ameliorative effect of the sea cucumber Holothuria arenicola extract against gastric ulcer in rats. J Basic Appl Zoology. 72:16–25. 2015. View Article : Google Scholar

30 

Dakrory AI, Fahmy SR, Soliman AM, Mohamed AS and Amer SA: Protective and curative effects of the sea cucumber Holothuria atra extract against DMBA-induced hepatorenal diseases in rats. Biomed Res Int. 2015:5636522015. View Article : Google Scholar : PubMed/NCBI

31 

Yahyavi M, Afkhami M, Mokhleci A, Ehsanpour M, Khazaali1 A, Khoshnood R and Jvadi A: Fatty acid in local sea cucumber species from Persian Gulf (Qeshm island). Ann Biol Res. 3:3597–3601. 2012.

32 

Coopersmith CM, Chang KC, Swanson PE, Tinsley KW, Stromberg PE, Buchman TG, Karl IE and Hotchkiss RS: Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Crit Care Med. 30:195–201. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Coopersmith CM, Stromberg PE, Dunne WM, Davis CG, Amiot DM II, Buchman TG, Karl IE and Hotchkiss RS: Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA. 287:1716–1721. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Oliver L and Vallette FM: The role of caspases in cell death and differentiation. Drug Resist Updat. 8:163–170. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Nishikawa Y, Furukawa A, Shiga I, Muroi Y, Ishii T, Hongo Y, Takahashi S, Sugawara T, Koshino H and Ohnishi M: Cytoprotective effects of lysophospholipids from sea cucumber holothuria atra. PLoS One. 10:e01357012015. View Article : Google Scholar : PubMed/NCBI

36 

Nemzek JA, Hugunin KMS and Opp MR: Modeling sepsis in the laboratory: Merging sound science with animal well-being. Comp Med. 58:120–128. 2008.PubMed/NCBI

37 

Ercan M and Ozdemir S: The contribution to studies of the effect of β-glucan on plasma viscosity in a rat sepsis model. Med Sci Disc. 2:148–153. 2015. View Article : Google Scholar

38 

Chien WS, Chen YH, Chiang PC, Hsiao HW, Chuang SM, Lue SI and Hsu C: Suppression of autophagy in rat liver at late stage of polymicrobial sepsis. Shock. 35:506–511. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Lo S, Yuan SS, Hsu C, Cheng YJ, Chang YF, Hsueh HW, Lee PH and Hsieh YC: Lc3 over-expression improves survival and attenuates lung injury through increasing autophagosomal clearance in septic mice. Ann Surg. 257:352–363. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Purcell SW, Samyn Y and Conand C: Commercially important sea cucumbers of the world. FAO Species Catalogue for Fishery Purposes No. 6. Food and Agriculture Organization. Rome: 2012.

41 

Adibpour N, Nasr F, Nematpour F, Shakouri A and Ameri A: Antibacterial and antifungal activity of Holothuria leucospilota isolated from Persian Gulf and Oman sea. Jundishapur J Microbiol. 7:e87082014. View Article : Google Scholar : PubMed/NCBI

42 

Attia HF, Kandiel MM, Ismail TA, Soliman MM, Nassan MA and Mansour AA: Immunohistochemical, cellular localization and expression of inhibin hormone in the buffalo (Bubalus bubalis) adenohypophysis at different ages. J Vet Anat. 5:83–104. 2012.

43 

Bancroft JD, Cook HC and Turner DR: Manual of histological techniques and their diagnostic application (2nd). Churchill Livingstone. London: 1994.

44 

Zarnescu O, Brehar FM, Chivu M and Ciurea AV: Immunohistochemical localization of caspase-3, caspase-9 and Bax in U87 glioblastoma xenografts. J Mol Histol. 39:561–569. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Toral-Granda V, Lovatelli A and Vasconcellos M: Sea cucumbers - A global review of fisheries and trade. FAO Fisheries and Aquaculture Technical Paper 516. Food and Agriculture Organization. Rome: 2008.

46 

Hasan MH: Stock assessment of holothuroid populations in the Red Sea waters of Saudi Arabia. SPC Beche-de-mer Information Bulletin 29. Eeckhaut I: Secretariat of the Pacific Community. (Nouméa). 31–37. 2009.

47 

Dhinakaran DI and Lipton AP: Bioactive compounds from Holothuria atra of Indian ocean. Springerplus. 3:6732014. View Article : Google Scholar : PubMed/NCBI

48 

Esmat AY, Said MM, Soliman AA, El-Masry KS and Badiea EA: Bioactive compounds, antioxidant potential and hepatoprotective activity of sea cucumber (Holothuria atra) against thioacetamide intoxication in rats. Nutrition. 29:258–267. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Baiomy A and Saad D: Histopathological and immunohistochemical studies of antiseptic effect of Sepia officinalis against induced sepsis in male albino rats (Rattus norvegicus). World J Med Sci. 12:303–315. 2015.

50 

Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S and Dhama K: Oxidative stress, prooxidants and antioxidants: The interplay. Biomed Res Int. 2014:7612642014. View Article : Google Scholar : PubMed/NCBI

51 

March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, Gillis S, Henney CS, Kronheim SR and Grabstein K: Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315:641–647. 1985. View Article : Google Scholar : PubMed/NCBI

52 

Bankers-Fulbright JL, Kalli KR and Mckean DJ: Interleukin-1 signal transduction. Life Sci. 59:61–83. 1996. View Article : Google Scholar : PubMed/NCBI

53 

Wang Q, Zhang H, Zhao B and Fei H: IL-1beta caused pancreatic beta-cells apoptosis is mediated in part by endoplasmic reticulum stress via the induction of endoplasmic reticulum Ca2+ release through the c-Jun N-terminal kinase pathway. Mol Cell Biochem. 324:183–190. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Jiao L, Li X, Li T, Jiang P and Zhang L, Wu M and Zhang L: Characterization and anti-tumor activity of alkali-extracted polysaccharide from Enteromorpha intestinalis. Int Immunopharmacol. 9:324–329. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Zhong Y, Khan MA and Shahidi F: Compositional characteristics and antioxidant properties of fresh and processed sea cucumber (Cucumaria frondosa). J Agric Food Chem. 55:1188–1192. 2007. View Article : Google Scholar : PubMed/NCBI

56 

da Silva Gomes EC, Jimenez GC, da Silva LC, de Sá FB, de Souza KP, Paiva GS and de Souza IA: Evaluation of antioxidant and antiangiogenic properties of caesalpinia echinata extracts. J Cancer. 5:143–150. 2014. View Article : Google Scholar

57 

Chenghui L, Beiwei Z, Xiuping D and Liguo C: Study on the separation and antioxidant activity of enzymatic hydrolysates from sea cucumber. Food Ferment Ind. 33:50–53. 2007.

58 

Chen Y, Miao Y, Huang L, Li J, Sun H, Zhao Y, Yang J and Zhou W: Antioxidant activities of saponins extracted from Radix trichosanthis: An in vivo and in vitro evaluation. BMC Complement Altern Med. 14:1–8. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Li SP, Zhao KJ, Ji ZN, Song ZH, Dong TT, Lo CK, Cheung JK, Zhu SQ and Tsim KW: A polysaccharide isolated from Cordyceps sinensis, a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury. Life Sci. 73:2503–2513. 2003. View Article : Google Scholar : PubMed/NCBI

60 

Althunibat OY, Hashim RB, Taher M, Daud JM, Ikeda MA and Zali BI: In vitro antioxidant and antiproliferative activities of three Malaysian sea cucumber species. Eur J Sci Res. 37:376–387. 2009.

61 

Xu Y, Chen J, Yu X, Tao W, Jiang F, Yin Z and Liu C: Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice. Inflamm Res. 59:871–877. 2010. View Article : Google Scholar : PubMed/NCBI

62 

Hu TJ, Wei XJ, Zhang X, Cheng FS, Shuai XH, Zhang L and Kang L: Protective effect of Potentilla anserine polysaccharide (PAP) on hydrogen peroxide induced apoptosis in murine splenic lymphocytes. Carbohyd Polym. 79:356–361. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Saad DY, Baiomy AA and Mansour AA: Antiseptic effect of sea cucumber (Holothuria atra) against multi-organ failure induced by sepsis: Molecular and histopathological study. Exp Ther Med 12: 222-230, 2016.
APA
Saad, D.Y., Baiomy, A.A., & Mansour, A.A. (2016). Antiseptic effect of sea cucumber (Holothuria atra) against multi-organ failure induced by sepsis: Molecular and histopathological study. Experimental and Therapeutic Medicine, 12, 222-230. https://doi.org/10.3892/etm.2016.3321
MLA
Saad, D. Y., Baiomy, A. A., Mansour, A. A."Antiseptic effect of sea cucumber (Holothuria atra) against multi-organ failure induced by sepsis: Molecular and histopathological study". Experimental and Therapeutic Medicine 12.1 (2016): 222-230.
Chicago
Saad, D. Y., Baiomy, A. A., Mansour, A. A."Antiseptic effect of sea cucumber (Holothuria atra) against multi-organ failure induced by sepsis: Molecular and histopathological study". Experimental and Therapeutic Medicine 12, no. 1 (2016): 222-230. https://doi.org/10.3892/etm.2016.3321
Copy and paste a formatted citation
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Spandidos Publications style
Saad DY, Baiomy AA and Mansour AA: Antiseptic effect of sea cucumber (Holothuria atra) against multi-organ failure induced by sepsis: Molecular and histopathological study. Exp Ther Med 12: 222-230, 2016.
APA
Saad, D.Y., Baiomy, A.A., & Mansour, A.A. (2016). Antiseptic effect of sea cucumber (Holothuria atra) against multi-organ failure induced by sepsis: Molecular and histopathological study. Experimental and Therapeutic Medicine, 12, 222-230. https://doi.org/10.3892/etm.2016.3321
MLA
Saad, D. Y., Baiomy, A. A., Mansour, A. A."Antiseptic effect of sea cucumber (Holothuria atra) against multi-organ failure induced by sepsis: Molecular and histopathological study". Experimental and Therapeutic Medicine 12.1 (2016): 222-230.
Chicago
Saad, D. Y., Baiomy, A. A., Mansour, A. A."Antiseptic effect of sea cucumber (Holothuria atra) against multi-organ failure induced by sepsis: Molecular and histopathological study". Experimental and Therapeutic Medicine 12, no. 1 (2016): 222-230. https://doi.org/10.3892/etm.2016.3321
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