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Article

Zingiber mioga reduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice

  • Authors:
    • Da‑Hye Lee
    • Jiyun Ahn
    • Young Jin Jang
    • Tae‑Youl Ha
    • Chang Hwa Jung
  • View Affiliations / Copyright

    Affiliations: Department of Food Biotechnology, Korea University of Science and Technology, Seongnam, Gyeonggi 13539, Republic of Korea, Metabolic Mechanism Research Group, Korea Food Research Institute, Seongnam, Gyeonggi 13539, Republic of Korea
  • Pages: 369-376
    |
    Published online on: May 11, 2016
       https://doi.org/10.3892/etm.2016.3331
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Abstract

Zingiber mioga is a perennial herb belonging to the ginger family (Zingiberaceae) that is used medicinally to treat cough and rheumatism in China and consumed throughout Japan. The aim of the present study was to investigate the anti‑obesity effects of Z. mioga following extraction with distilled water or 70% ethanol. In 3T3‑L1 preadipocyte cells, Z. mioga water extract (ZMW) markedly inhibited adipogenesis, whereas the ethanol extract had no effect. In addition, we conducted ZMW feeding experiments (0.25 or 0.5% ZMW) in high‑fat diet (HFD)‑fed mice to examine the anti‑obesity effects of Z. mioga in vivo. Body weight and serum triglyceride and cholesterol levels significantly decreased in the HFD + ZMW 0.5% group. Notably, ZMW decreased liver weight but not adipose tissue weight. Furthermore, insulin resistance and hepatic mRNA expression of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase and G6Pase, were improved in the HFD + ZMW 0.5% group. Furthermore, ZMW treatment decreased hepatic lipogenic gene expression; however, it did not alter adipogenesis in fat tissue, suggesting that ZMW inhibits hepatosteatosis through the suppression of lipogenesis. ZMW improved HFD-induced hepatic inflammation. Collectively, the present findings suggest that ZMW may serve as a new and promising strategy for the treatment of hepatosteatosis.
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Copy and paste a formatted citation
Spandidos Publications style
Lee DH, Ahn J, Jang YJ, Ha TY and Jung CH: Zingiber mioga reduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice. Exp Ther Med 12: 369-376, 2016.
APA
Lee, D., Ahn, J., Jang, Y.J., Ha, T., & Jung, C.H. (2016). Zingiber mioga reduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice. Experimental and Therapeutic Medicine, 12, 369-376. https://doi.org/10.3892/etm.2016.3331
MLA
Lee, D., Ahn, J., Jang, Y. J., Ha, T., Jung, C. H."Zingiber mioga reduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice". Experimental and Therapeutic Medicine 12.1 (2016): 369-376.
Chicago
Lee, D., Ahn, J., Jang, Y. J., Ha, T., Jung, C. H."Zingiber mioga reduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice". Experimental and Therapeutic Medicine 12, no. 1 (2016): 369-376. https://doi.org/10.3892/etm.2016.3331
Copy and paste a formatted citation
x
Spandidos Publications style
Lee DH, Ahn J, Jang YJ, Ha TY and Jung CH: Zingiber mioga reduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice. Exp Ther Med 12: 369-376, 2016.
APA
Lee, D., Ahn, J., Jang, Y.J., Ha, T., & Jung, C.H. (2016). Zingiber mioga reduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice. Experimental and Therapeutic Medicine, 12, 369-376. https://doi.org/10.3892/etm.2016.3331
MLA
Lee, D., Ahn, J., Jang, Y. J., Ha, T., Jung, C. H."Zingiber mioga reduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice". Experimental and Therapeutic Medicine 12.1 (2016): 369-376.
Chicago
Lee, D., Ahn, J., Jang, Y. J., Ha, T., Jung, C. H."Zingiber mioga reduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice". Experimental and Therapeutic Medicine 12, no. 1 (2016): 369-376. https://doi.org/10.3892/etm.2016.3331
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