Safety and effectiveness of CT-guided percutaneous pulmonary paracentesis and tuberculoma perfusing chemotherapy for the treatment of pleural tuberculosis

Geng,Shujun; Li,Lijuan; Liu,Jianling; Song,Tao

doi:10.3892/etm.2016.3337

August-2016 Volume 12 Issue 2

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August-2016 Volume 12 Issue 2

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Safety and effectiveness of CT-guided percutaneous pulmonary paracentesis and tuberculoma perfusing chemotherapy for the treatment of pleural tuberculosis

Authors:
- Shujun Geng
- Lijuan Li
- Jianling Liu
- Tao Song
View Affiliations / Copyright

Affiliations: Ward 4, Department of Tuberculous Internal Medicine, Hebei Chest Hospital, Shijiazhuang, Hebei, P.R. China, Cadre Ward 2, Bethune International Peace Hospital, Shijiazhuang, Hebei, P.R. China, Department of Respiratory Medicine, Hebei Chest Hospital, Shijiazhuang, Hebei, P.R. China

Copyright: © Geng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 957-960
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Published online on: May 12, 2016

https://doi.org/10.3892/etm.2016.3337
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Abstract

The aim of the study was to compare the mid- and long-term effects of different treatments such as CT-guided percutaneous pulmonary paracentesis, tuberculoma perfusing chemotherapy and whole‑body standard chemotherapy or extended chemotherapy on safety and effectiveness for pleural chemotherapy. A total of 60 subjects diagnosed to have pleural tuberculosis between February 2010 and February 2014 were prospectively selected for this study and were considered as the experimental group. Seventy pleural tuberculosis patients who underwent treatment between February 2006 and February 2010 were considered as the control group. The patients in the experimental group were treated with CT-guided percutaneous pulmonary paracentesis and tuberculoma perfusing chemotherapy of not more than three courses with each course consisting of administration of 0.1 g isoniazid, n 0.5 gkanamyci, 0.2 g levofloxacin, and 1 ml lidocaine once a week for four times. The patients in the control group were treated with whole-body standard or extended chemotherapy regimen 3~6HRZE(S)/6~12HR. The patients were followed up for 18 months and the treatment effects were compared. The diameter of tuberculoma in patients of the experimental group during 6, 12 and 18 months was shorter than that of the control group (P<0.05). The total effective rate of treatment and the duration of treatment in experimental group during 18 months were higher than that of control group (P<0.05). The frequency of drug-related complications were lower in comparison with the control group (P<0.05). No surgically acquired complications were observed in the experimental group. Thus, treatments such as CT-guided percutaneous pulmonary paracentesis and tuberculoma perfusing chemotherapy for pleural tuberculosis are safe and effective, which has greater value and can be promoted for use in the clinical setting.

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1	Bozorgmehr K and San Sebastian M: Trade liberalization and tuberculosis incidence: a longitudinal multi-level analysis in 22 high burden countries between 1990 and 2010. Health Policy Plan. 29:328–351. 2014. View Article : Google Scholar : PubMed/NCBI
2	Chen W, Shu W, Wang M, Hou Y, Xia Y, Xu W, Bai L, Nie S, Cheng S and Xu Y: Pulmonary tuberculosis incidence and risk factors in rural areas of China: A cohort study. PLoS One. 8:e581712013. View Article : Google Scholar : PubMed/NCBI
3	Hervé C, Bergot E, Veziris N and Blanc FX: Tuberculosis in 2015: from diagnosis to the detection of multiresistant cases. Rev Mal Respir. 32:784–790. 2015.(In French). View Article : Google Scholar : PubMed/NCBI
4	Wang Z, Xu LL, Wu YB, Wang XJ, Yang Y, Zhang J, Tong ZH and Shi HZ: Diagnostic value and safety of medical thoracoscopy in tuberculous pleural effusion. Respir Med. 109:1188–1192. 2015. View Article : Google Scholar : PubMed/NCBI
5	Zeng J, Song Z, Cai X, Huang S, Wang W, Zhu Y, Huang Y, Kong B, Xiang W, Lin D, et al: Tuberculous pleurisy drives marked effector responses of γδ, CD4⁺, and CD8⁺ T cell subpopulations in humans. J Leukoc Biol. 98:851–7. 2015. View Article : Google Scholar : PubMed/NCBI
6	Caminero Luna JA: Update on the diagnosis and treatment of pulmonary tuberculosis. Rev Clin Esp. Oct 19–2015.(Epub ahead of print).
7	Dixon G, de Fonseka D and Maskell N: Pleural controversies: image guided biopsy vs. thoracoscopy for undiagnosed pleural effusions? J Thorac Dis. 7:1041–1051. 2015.PubMed/NCBI
8	Vorster MJ, Allwood BW, Diacon AH and Koegelenberg CF: Tuberculous pleural effusions: advances and controversies. J Thorac Dis. 7:981–991. 2015.PubMed/NCBI
9	Alexander GR and Biccard B: A retrospective review comparing treatment outcomes of adjuvant lung resection for drug-resistant tuberculosis in patients with and without human immunodeficiency virus co-infection. Eur J Cardiothorac Surg. 4:ezv2282015.
10	Navarro Ballester A and Marco Domenech SF: Update on the radiological study of pulmonary tuberculosis. Radiologia. 57:434–444. 2015.(In Spanish). PubMed/NCBI
11	Koegelenberg CF, Irusen EM, von Groote-Bidlingmaier F, Bruwer JW, Batubara EM and Diacon AH: The utility of ultrasound-guided thoracentesis and pleural biopsy in undiagnosed pleural exudates. Thorax. 70:995–997. 2015. View Article : Google Scholar : PubMed/NCBI
12	Aggarwal AN, Agarwal R, Gupta D, Dhooria S and Behera D: Interferon gamma release assays for diagnosis of pleural tuberculosis: a systematic review and meta-analysis. J Clin Microbiol. 53:2451–2459. 2015. View Article : Google Scholar : PubMed/NCBI
13	Zhang L, Huang H, Zou P and Zhang Z: Treatment for pleura tubercle tumor with percutaneous pulmonary paracentesis and perfusing chemotherapy led by CT. J Nat Med. 18:206–210. 2008.
14	Yu X, Ge X, Wang X, Mi R and Wang J: The treatment of refractoriness cavitary pulmonary tuberculosis with CT-guided percutaneous pulmonary paracentesis and perfusing chemotherapy. Chin J CT MRI. 6:74–75. 2008.
15	Shao W, Zhu Y and Zhou R: Clinical analysis on pleural tuberculoma in the process of treating tuberculous pleurisy. Chin Mod Doct. 12:15–16. 2014.
16	Ng YL, Patsios D, Roberts H, Walsham A, Paul NS, Chung T, Herman S and Weisbrod G: CT-guided percutaneous fine-needle aspiration biopsy of pulmonary nodules measuring 10 mm or less. Clin Radiol. 63:272–277. 2008. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Safety and effectiveness of CT-guided percutaneous pulmonary paracentesis and tuberculoma perfusing chemotherapy for the treatment of pleural tuberculosis

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