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Article

Prognostic factors affecting early colectomy in patients with moderate to severe ulcerative colitis treated with calcineurin inhibitors

  • Authors:
    • Hiromitsu Ban
    • Shigeki Bamba
    • Atsushi Nishida
    • Osamu Inatomi
    • Makoto Shioya
    • Ken‑Ichiro Takahashi
    • Hirotsugu Imaeda
    • Masaki Murata
    • Masaya Sasaki
    • Tomoyuki Tsujikawa
    • Akira Andoh
  • View Affiliations / Copyright

    Affiliations: Division of Endoscopy, Shiga University of Medical Science, Ōtsu, Shiga 520‑2192, Japan, Division of Gastroenterology, Shiga University of Medical Science, Ōtsu, Shiga 520‑2192, Japan, Division of Clinical Nutrition, Shiga University of Medical Science, Ōtsu, Shiga 520‑2192, Japan, Department of Comprehensive Internal Medicine, Shiga University of Medical Science, Ōtsu, Shiga 520‑2192, Japan
  • Pages: 829-834
    |
    Published online on: May 16, 2016
       https://doi.org/10.3892/etm.2016.3341
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Abstract

Calcineurin inhibitors (CNIs) such as cyclosporine A (CSA) and tacrolimus (FK506) are often used as a second-line drug for steroid-refractory or steroid‑dependent patients with ulcerative colitis (UC). The aim of the present study was to determine the prognostic factors for early colectomy. A total of 85 hospitalized patients with UC (CSA, 50 patients; FK506, 35 patients) were enrolled. Colectomy carried out within 60 days of starting CNI therapy was defined as ʻearly colectomyʼ. To assess the prognostic factors affecting early colectomy, clinical practical variables, including the Onodera‑prognostic nutritional index (O‑PNI): 10xAlb+0.005x (total lymphocyte count), were analyzed. The results demonstrated that the significant factors predicting early colectomy were i) disease severity, ii) immunomodulator‑naïve history, iii) lower serum hematocrit, iv) lower serum albumin and v) lower O‑PNI. In addition, the significant factors predicting overall colectomy were as follows: i) C7‑HRP positivity and ii) >10,000 mg of prednisolone used prior to the initiation of CNI treatment. The combination of hematocrit and O‑PNI enhanced the prediction of early colectomy. Clinical variables such as hematocrit and O‑PNI were the significant factors predicting colectomy. These results may be used as a guide to predict the outcome of patients with UC in clinical settings.
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Copy and paste a formatted citation
Spandidos Publications style
Ban H, Bamba S, Nishida A, Inatomi O, Shioya M, Takahashi KI, Imaeda H, Murata M, Sasaki M, Tsujikawa T, Tsujikawa T, et al: Prognostic factors affecting early colectomy in patients with moderate to severe ulcerative colitis treated with calcineurin inhibitors. Exp Ther Med 12: 829-834, 2016.
APA
Ban, H., Bamba, S., Nishida, A., Inatomi, O., Shioya, M., Takahashi, K. ... Andoh, A. (2016). Prognostic factors affecting early colectomy in patients with moderate to severe ulcerative colitis treated with calcineurin inhibitors. Experimental and Therapeutic Medicine, 12, 829-834. https://doi.org/10.3892/etm.2016.3341
MLA
Ban, H., Bamba, S., Nishida, A., Inatomi, O., Shioya, M., Takahashi, K., Imaeda, H., Murata, M., Sasaki, M., Tsujikawa, T., Andoh, A."Prognostic factors affecting early colectomy in patients with moderate to severe ulcerative colitis treated with calcineurin inhibitors". Experimental and Therapeutic Medicine 12.2 (2016): 829-834.
Chicago
Ban, H., Bamba, S., Nishida, A., Inatomi, O., Shioya, M., Takahashi, K., Imaeda, H., Murata, M., Sasaki, M., Tsujikawa, T., Andoh, A."Prognostic factors affecting early colectomy in patients with moderate to severe ulcerative colitis treated with calcineurin inhibitors". Experimental and Therapeutic Medicine 12, no. 2 (2016): 829-834. https://doi.org/10.3892/etm.2016.3341
Copy and paste a formatted citation
x
Spandidos Publications style
Ban H, Bamba S, Nishida A, Inatomi O, Shioya M, Takahashi KI, Imaeda H, Murata M, Sasaki M, Tsujikawa T, Tsujikawa T, et al: Prognostic factors affecting early colectomy in patients with moderate to severe ulcerative colitis treated with calcineurin inhibitors. Exp Ther Med 12: 829-834, 2016.
APA
Ban, H., Bamba, S., Nishida, A., Inatomi, O., Shioya, M., Takahashi, K. ... Andoh, A. (2016). Prognostic factors affecting early colectomy in patients with moderate to severe ulcerative colitis treated with calcineurin inhibitors. Experimental and Therapeutic Medicine, 12, 829-834. https://doi.org/10.3892/etm.2016.3341
MLA
Ban, H., Bamba, S., Nishida, A., Inatomi, O., Shioya, M., Takahashi, K., Imaeda, H., Murata, M., Sasaki, M., Tsujikawa, T., Andoh, A."Prognostic factors affecting early colectomy in patients with moderate to severe ulcerative colitis treated with calcineurin inhibitors". Experimental and Therapeutic Medicine 12.2 (2016): 829-834.
Chicago
Ban, H., Bamba, S., Nishida, A., Inatomi, O., Shioya, M., Takahashi, K., Imaeda, H., Murata, M., Sasaki, M., Tsujikawa, T., Andoh, A."Prognostic factors affecting early colectomy in patients with moderate to severe ulcerative colitis treated with calcineurin inhibitors". Experimental and Therapeutic Medicine 12, no. 2 (2016): 829-834. https://doi.org/10.3892/etm.2016.3341
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