Open Access

Novel association of soluble intercellular adhesion molecule 1 and soluble P-selectin with the ABO blood group in a Chinese population

  • Authors:
    • Wenjing Zhang
    • Qun Xu
    • Yunlong Zhuang
    • Yuanfeng Chen
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  • Published online on: May 17, 2016     https://doi.org/10.3892/etm.2016.3347
  • Pages: 909-914
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Recent studies have reported that the ABO gene can affect circulating expression levels of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble P-selectin (sP-selectin) in Caucasians. However, several factors may affect the association, including the distribution and variations of the ABO gene, ethnic diversity and the inflammatory response status. The aim of the present study was to investigate this issue in Asian subjects of various blood groups. A total of 800 blood samples were randomly selected from healthy blood donors. The ABO blood groups were examined using standard serological tests, and ABO genotypes of group A and group AB specimens were analyzed. Plasma concentrations of sICAM‑1 and sP‑selectin were detected by standard enzyme‑linked immunosorbent assays. In healthy Chinese individuals, blood group A was detected to be significantly associated with lower circulating expression levels of sICAM‑1 and sP‑selectin, compared with group O. Individuals with ≥1 A1 allele had significantly lower expression levels of sICAM‑1 and sP‑selectin compared with all other ABO groups. The data indicate the significant association of ABO blood group antigens with sICAM‑1 and sP‑selectin expression levels in a healthy Chinese population, independent of the specific variations and distributions of ABO blood groups among ethnic populations. This result provides evidence for the previously unidentified role of ABO blood group antigens in the regulation of the inflammatory adhesion process. Accordingly, it can be proposed that ABO blood groups may require consideration when soluble adhesion molecules are identified as predictors for cardiovascular disease.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang W, Xu Q, Zhuang Y and Chen Y: Novel association of soluble intercellular adhesion molecule 1 and soluble P-selectin with the ABO blood group in a Chinese population. Exp Ther Med 12: 909-914, 2016.
APA
Zhang, W., Xu, Q., Zhuang, Y., & Chen, Y. (2016). Novel association of soluble intercellular adhesion molecule 1 and soluble P-selectin with the ABO blood group in a Chinese population. Experimental and Therapeutic Medicine, 12, 909-914. https://doi.org/10.3892/etm.2016.3347
MLA
Zhang, W., Xu, Q., Zhuang, Y., Chen, Y."Novel association of soluble intercellular adhesion molecule 1 and soluble P-selectin with the ABO blood group in a Chinese population". Experimental and Therapeutic Medicine 12.2 (2016): 909-914.
Chicago
Zhang, W., Xu, Q., Zhuang, Y., Chen, Y."Novel association of soluble intercellular adhesion molecule 1 and soluble P-selectin with the ABO blood group in a Chinese population". Experimental and Therapeutic Medicine 12, no. 2 (2016): 909-914. https://doi.org/10.3892/etm.2016.3347