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Antimicrobial prophylaxis in caesarean section delivery

  • Authors:
    • Ronghua Liu
    • Lin Lin
    • Dujuan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics, People's Hospital of Linyi, Linyi, Shandong 276000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 961-964
    |
    Published online on: May 18, 2016
       https://doi.org/10.3892/etm.2016.3350
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Abstract

Antimicrobial prophylaxis is used routinely for pre-, intra- and post-operative caesarean section. One of the most important risk factors for postpartum infection is caesarean delivery. Caesarean section shows a higher incidence of infection than vaginal delivery. It is complicated by surgical site infections, endometritis or urinary tract infection. The aim of the present study was to assess the usage of antimicrobials in women undergoing caesarean section at a Tertiary Care Hospital. A prospective study was conducted in 100 women during the period of February 2013 to August 2013 in the inpatient Department of Gynaecology and Obstetrics. Data collected included the age of the patient, gravidity, and type of caesarean section, which was analyzed for the nature and number of antimicrobials prescribed, duration of treatment, polypharmacy, fixed‑dose combinations, generic/brand names used and failure of prophylaxis. Antimicrobial prophylaxis was administered to the patients. The most commonly prescribed antimicrobial was a combination of ceftriaxone and sulbactam. Of 100 patients, 87% were aged 20-35 years. The highest proportion of patients were primigravida 72%. Elective procedure was carried out in 38%, the remaining were emergency C-section in whom intra- and post-operative antimicrobial prophylaxis was given for a duration of 7 days. In total, 27% of patients were reported with infection even after the antimicrobial prophylaxis. In conclusion, pre-operative prophylaxis was given in the early rupture of membranes. Fixed‑dose combinations were preferred. Incidence of infection even after antimicrobial prophylaxis was reported due to pre‑existing infection, debilitating disease or prolonged rupture of membranes. Patients with recurrent infection were shifted to amoxicillin and clavulinic acid combination. Drugs were prescribed only by brand names which is of concern.
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Copy and paste a formatted citation
Spandidos Publications style
Liu R, Lin L and Wang D: Antimicrobial prophylaxis in caesarean section delivery. Exp Ther Med 12: 961-964, 2016.
APA
Liu, R., Lin, L., & Wang, D. (2016). Antimicrobial prophylaxis in caesarean section delivery. Experimental and Therapeutic Medicine, 12, 961-964. https://doi.org/10.3892/etm.2016.3350
MLA
Liu, R., Lin, L., Wang, D."Antimicrobial prophylaxis in caesarean section delivery". Experimental and Therapeutic Medicine 12.2 (2016): 961-964.
Chicago
Liu, R., Lin, L., Wang, D."Antimicrobial prophylaxis in caesarean section delivery". Experimental and Therapeutic Medicine 12, no. 2 (2016): 961-964. https://doi.org/10.3892/etm.2016.3350
Copy and paste a formatted citation
x
Spandidos Publications style
Liu R, Lin L and Wang D: Antimicrobial prophylaxis in caesarean section delivery. Exp Ther Med 12: 961-964, 2016.
APA
Liu, R., Lin, L., & Wang, D. (2016). Antimicrobial prophylaxis in caesarean section delivery. Experimental and Therapeutic Medicine, 12, 961-964. https://doi.org/10.3892/etm.2016.3350
MLA
Liu, R., Lin, L., Wang, D."Antimicrobial prophylaxis in caesarean section delivery". Experimental and Therapeutic Medicine 12.2 (2016): 961-964.
Chicago
Liu, R., Lin, L., Wang, D."Antimicrobial prophylaxis in caesarean section delivery". Experimental and Therapeutic Medicine 12, no. 2 (2016): 961-964. https://doi.org/10.3892/etm.2016.3350
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