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Article Open Access

Fondaparinux vs. enoxaparin for the prevention of venous thromboembolism after total hip replacement: A meta-analysis

  • Authors:
    • Wen‑Jun Dong
    • Hui‑Juan Qian
    • Yan Qian
    • Ling Zhou
    • San‑Lian Hu
  • View Affiliations / Copyright

    Affiliations: Department of Nursing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 969-974
    |
    Published online on: May 18, 2016
       https://doi.org/10.3892/etm.2016.3351
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Abstract

The aim of the study was to compare the efficacy and safety profiles of fondaparinux and enoxaparin in preventing the venous thromboembolism (VTE) after total hip replacement. A systematic literature search in the PubMed, EMBASE and Cochrane library databases was performed to identify relevant articles published in English since inception up to November 16, 2014. The efficacy outcomes were all VTE, total deep vein thrombosis (DVT) and symptomatic VTE, while the safety outcome was major bleeding. Four eligible studies were included in the meta‑analysis. The incidences of total VTEs and DVTs were significantly decreased with the use of fondaparinux when compared to enoxaparin [total VTE: risk ratio (RR)=0.59, 95% confidence interval (CI): 0.46‑0.74, P<0.01; total DVT: RR=0.58, 95% CI: 0.46‑0.74, P<0.01]. Significantly fewer symptomatic VTEs and major bleeding cases were observed for the enoxaparin group (symptomatic VTE: RR=2.62, 95% CI: 1.07‑6.45, P=0.04; major bleeding: RR=1.75, 95% CI: 1.20‑2.53, P<0.01). In conclusion, the pooled analysis revealed that, compared to enoxaparin, fondaparinux was significantly more effective in preventing VTE after total hip replacements in terms of total VTEs and DVTs, although this was accompanied with an increased risk of major bleeding. However, the pooled analysis of two small sample trials from Japan failed to demonstrate any significant advantage for fondaparinux compared to enoxaparin.
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Copy and paste a formatted citation
Spandidos Publications style
Dong WJ, Qian HJ, Qian Y, Zhou L and Hu SL: Fondaparinux vs. enoxaparin for the prevention of venous thromboembolism after total hip replacement: A meta-analysis. Exp Ther Med 12: 969-974, 2016.
APA
Dong, W., Qian, H., Qian, Y., Zhou, L., & Hu, S. (2016). Fondaparinux vs. enoxaparin for the prevention of venous thromboembolism after total hip replacement: A meta-analysis. Experimental and Therapeutic Medicine, 12, 969-974. https://doi.org/10.3892/etm.2016.3351
MLA
Dong, W., Qian, H., Qian, Y., Zhou, L., Hu, S."Fondaparinux vs. enoxaparin for the prevention of venous thromboembolism after total hip replacement: A meta-analysis". Experimental and Therapeutic Medicine 12.2 (2016): 969-974.
Chicago
Dong, W., Qian, H., Qian, Y., Zhou, L., Hu, S."Fondaparinux vs. enoxaparin for the prevention of venous thromboembolism after total hip replacement: A meta-analysis". Experimental and Therapeutic Medicine 12, no. 2 (2016): 969-974. https://doi.org/10.3892/etm.2016.3351
Copy and paste a formatted citation
x
Spandidos Publications style
Dong WJ, Qian HJ, Qian Y, Zhou L and Hu SL: Fondaparinux vs. enoxaparin for the prevention of venous thromboembolism after total hip replacement: A meta-analysis. Exp Ther Med 12: 969-974, 2016.
APA
Dong, W., Qian, H., Qian, Y., Zhou, L., & Hu, S. (2016). Fondaparinux vs. enoxaparin for the prevention of venous thromboembolism after total hip replacement: A meta-analysis. Experimental and Therapeutic Medicine, 12, 969-974. https://doi.org/10.3892/etm.2016.3351
MLA
Dong, W., Qian, H., Qian, Y., Zhou, L., Hu, S."Fondaparinux vs. enoxaparin for the prevention of venous thromboembolism after total hip replacement: A meta-analysis". Experimental and Therapeutic Medicine 12.2 (2016): 969-974.
Chicago
Dong, W., Qian, H., Qian, Y., Zhou, L., Hu, S."Fondaparinux vs. enoxaparin for the prevention of venous thromboembolism after total hip replacement: A meta-analysis". Experimental and Therapeutic Medicine 12, no. 2 (2016): 969-974. https://doi.org/10.3892/etm.2016.3351
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