Anti‑allergic effect of Artemisia extract in rats

Deng,Yan; Liu,Zijun; Geng,Yiwei

doi:10.3892/etm.2016.3361

Anti‑allergic effect of Artemisia extract in rats

Authors:
- Yan Deng
- Zijun Liu
- Yiwei Geng
View Affiliations

Affiliations: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
Published online on: May 18, 2016 https://doi.org/10.3892/etm.2016.3361
Pages: 1130-1134

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Artemisia apiacea (also known as Artemisia annua L) is a herb commonly used in traditional Chinese medicine. In the early 1970s, artemisinin was isolated and identified as the active antimalarial ingredient, and thereafter, A. apiacea and artemisinin have been studied extensively, such as anti‑inflammation and antipyresis, antibacteria, antiparasitic and immunosuppression effects of A. apiacea extract. The present study investigated the extracts anti‑allergic effect obtained from the dried flowering tips of A. apiacea in rats. A systemic anaphylactic reaction model was induced in rats using compound 48/80. Artemisia extract was administered 1 h prior to the injection of compound 48/80. Artemisia was extracted from dried flowering tips of A. deserti using 80% ethanol. Subsequently, the systemic anaphylactic shock, histamine release, scratching behavior and vascular permeability induced by compound 48/80 were evaluated. The administration of Artemisia extract at 200 and 400 mg/kg doses suppressed the systemic anaphylactic shock induced by compound 48/80 in a dose‑dependent manner. Overall, the Artemisia extract was able to effectively decrease systemic anaphylactic shock, histamine release, scratching behavior and vascular permeability induced by compound 48/80 in a dose‑dependent manner.

View Figures

View References

1	Kiss B, Szántó M, Szklenár M, Brunyánszki A, Marosvölgyi T, Sárosi E, Remenyik É, Gergely P, Virág L, Decsi T, et al: Poly (ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity. Mol Med Rep. 11:2861–2867. 2015.PubMed/NCBI
2	Roth-Walter F, Gomez-Casado C, Pacios LF, Mothes-Luksch N, Roth GA, Singer J, Diaz-Perales A and Jensen-Jarolim E: Bet v 1 from birch pollen is a lipocalin-like protein acting as allergen only when devoid of iron by promoting Th2 lymphocytes. J Biol Chem. 289:17416–17421. 2014. View Article : Google Scholar : PubMed/NCBI
3	Mitoshi M, Kuriyama I, Nakayama H, Miyazato H, Sugimoto K, Kobayashi Y, Jippo T, Kuramochi K, Yoshida H and Mizushina Y: Suppression of allergic and inflammatory responses by essential oils derived from herbal plants and citrus fruits. Int J Mol Med. 33:1643–1651. 2014.PubMed/NCBI
4	Kim JH, Yi JS, Gong CH and Jang YJ: Development of Aspergillus protease with ovalbumin-induced allergic chronic rhinosinusitis model in the mouse. Am J Rhinol Allergy. 28:465–470. 2014. View Article : Google Scholar : PubMed/NCBI
5	Brandys J, Grimsøen A, Nilsen BM, Paulsen BS, Park HS and Hong CS: Cross-reactivity between pollen extracts from six artemisia species. Planta Med. 59:221–228. 1993. View Article : Google Scholar : PubMed/NCBI
6	Olsen OT, Frølund L, Heinig J, Jacobsen L and Svendsen UG: A double-blind, randomized study investigating the efficacy and specificity of immunotherapy with Artemisia vulgaris or Phleum pratense/Betula verrucosa. Allergol Immunopathol (Madr). 23:73–78. 1995.PubMed/NCBI
7	Subiza J, Subiza JL, Alonso M, Hinojosa M, Garcia R, Jerez M and Subiza E: Allergic conjunctivitis to chamomile tea. Ann Allergy. 65:127–132. 1990.PubMed/NCBI
8	Ryu JC, Park SM, Hwangbo M, Byun SH, Ku SK, Kim YW, Kim SC, Jee SY and Cho IJ: Methanol extract of Artemisia apiacea hance attenuates the expression of inflammatory mediators via NF-κB inactivation. Evid Based Complement Alternat Med. Feb 22–2013.(Epub ahead of print). View Article : Google Scholar
9	Shin TY, Park JH and Kim HM: Effect of Cryptotympana atrata extract on compound 48/80-induced anaphylactic reactions. J Ethnopharmacol. 66:319–325. 1999. View Article : Google Scholar : PubMed/NCBI
10	Noori A, Amjad L and Yazdani F: The effects of Artemisia deserti ethanolic extract on pathology and function of rat kidney. Avicenna J Phytomed. 4:371–376. 2014.PubMed/NCBI
11	Kuraishi Y, Nagasawa T, Hayashi K and Satoh M: Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur J Pharmacol. 275:229–233. 1995. View Article : Google Scholar : PubMed/NCBI
12	Du Q, Gu X, Cai J, Huang M and Su M: Chrysin attenuates allergic airway inflammation by modulating the transcription factors T-bet and GATA-3 in mice. Mol Med Rep. 6:100–104. 2012.PubMed/NCBI
13	Cheng LJ, Liu B, Ning B, Ming H, Wang C and Wan LX: High-intensity focused ultrasound for the treatment of allergic rhinitis using nasal endoscopy. Exp Ther Med. 5:320–322. 2013.PubMed/NCBI
14	Hui Y, Li L, Qian J, Guo Y and Zhang X and Zhang X: Efficacy analysis of three-year subcutaneous SQ-standardized specific immunotherapy in house dust mite-allergic children with asthma. Exp Ther Med. 7:630–634. 2014.PubMed/NCBI
15	Hollander SM, Joo SS and Wedner HJ: Factors that predict the success of cyclosporine treatment for chronic urticaria. Ann Allergy Asthma Immunol. 107:523–528. 2011. View Article : Google Scholar : PubMed/NCBI
16	Kim HH, Choi PH, Yoo JS, Jeon H, Chae BS, Park JS, Kim SH and Shin TY: Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation. Int J Mol Med. 29:303–310. 2012.PubMed/NCBI
17	Yong J, Chen GQ, Huang B and Wu S: Correlation between the ratio of T-bet/GATA-3 and the levels of IL-4 and IFN-γ in patients with allergic asthma. Mol Med Rep. 4:663–666. 2011.PubMed/NCBI
18	Kim JY, Kim DY, Lee YS, Lee BK, Lee KH and Ro JY: DA-9601, Artemisia asiatica herbal extract, ameliorates airway inflammation of allergic asthma in mice. Mol Cells. 22:104–112. 2006.PubMed/NCBI
19	Guo H and Liu MP: Mechanism of traditional Chinese medicine in the treatment of allergic rhinitis. Chin Med J (Engl). 126:756–760. 2013.PubMed/NCBI
20	Zhang F, Fu X, Lv Z, Shen Q, Yan T, Jiang W, Wang G, Sun X and Tang K: Type 2C phosphatase 1 of Artemisia annua L. Is a negative regulator of ABA signaling. Biomed Res Int. 2014:5217942014.PubMed/NCBI
21	Yin Y, Gong FY, Wu XX, Sun Y, Li YH, Chen T and Xu Q: Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita. J Ethnopharmacol. 120:1–6. 2008. View Article : Google Scholar : PubMed/NCBI
22	Rasool R, Ganai BA, Akbar S and Kamili AN: Free radical scavenging potential of in vitro raised and greenhouse acclimatized plants of Artemisia amygdalina. Chin J Nat Med. 11:377–384. 2013.PubMed/NCBI
23	Park JM, Hahm KB, Kwon SO and Kim EH: The Anti-inflammatory effects of acidic polysaccharide from Artemisia capillaris on Helicobacter pylori infection. J Cancer Prev. 18:161–168. 2013. View Article : Google Scholar : PubMed/NCBI
24	Puc M and Wolski T: Forecasting of the selected features of Poaceae (R. Br.) Barnh., Artemisia L. and Ambrosia L. pollen season in Szczecin, north-western Poland, using Gumbel's distribution. Ann Agric Environ Med. 20:36–47. 2013.PubMed/NCBI